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The diagnostic value of the lactate concentration in the vaginal fluid for diagnosis of premature rupture of membranes
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| N Nazari 1, M Ahmadi, M Mazani, H Alavimajd, M Refaei, M Hedayati |
| 1- , nasrin.nazari43@gmail.com |
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Abstract: (3438 Views) |
| Abstract
Background & aim: Accurate and timely diagnosis of premature rupture of fetal membranes has a major role in reducing infant and mother mortality and morbidity .The purpose of this study was to determine the diagnostic value of the lactate concentration in vaginal fluid of pregnant women with premature rupture of fetal membranes (PROM).
Methods: In this diagnostic study, 90 pregnant women with single pregnancy at the gestational age of 20-41 weeks were enrolled and randomly divided into two equal groups of 45. The first group includes pregnant women with premature rupture of membranes and the second groups were included pregnant women with intact membranes. To confirm or reject premature rupture of membranes, speculum examination, Fern and Nitrazyn was used in both groups. Lactate concentration test of vaginal fluid was performed by enzymatic colorimetric assay via handheld device Lactate Pro. Data were analyzed using descriptive statistics with SPSS 17 software.
Results: Lactate threshold concentration was determined at level of 4.6 mM/L. Lactate concentration in vaginal secretions for the diagnosis of premature rupture of membranes, a positive test with a sensitivity of 95.6%, specificity 97.8%, the accuracy of the 96.6%, positive predictive value of 97.7%, , PPV 95.6% and negative predictive value of 95.6% were obtained respectively.
Conclusion: Test of Lactate concentration in vaginal fluid test is a valid, quick and easy with high sensitivity and specificity for the diagnosis of premature rupture of membranes the fetus of pregnant women. |
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| Keywords: Key words: Premature rupture of membranes, vaginal fluids, lactate level |
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Full-Text [PDF 626 kb]
(793 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/04/11 | Accepted: 2015/04/11 | Published: 2015/04/11
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