Background & aim: Most research on the effects of exercise on people with MS rehabilitation exercises sclerosis (MS)  have been carried out on patients with low to moderate disability, but research on patients with different severity of disability (physical disability scale of zero to 10) still has to be carefully considered. The aim of this study was to investigate the effects of twelve weeks of rehabilitation exercises personalized compound exercise on physiological cost index (PCI) and average speed walking in patients with MS at various levels of disability.

Methods: The present research was a semi-experimental practical study. Thus among female patients admitted to the MS Association of Shahrekord city, 96 people were chosen on the basis of physical disability scores and divided into three groups. The first group consisted of less than 5/4 a total of 44 people, the second group between 5/65 and 5/6 up third of each 26 patients were then randomly assigned to an experimental group and a control group. Afterwards each group was divided randomly into an experimental group and a control group. The first group (the scale of disability less than 4.5), N= 44. The second group (the scale of disability 5 - 6.5), N=26. Also 26 patients were in the third group (the scale of disability 6.5 and above). In addition, they were divided into 6 experimental and control groups. Training programs for experimental groups were 12 weeks, three sessions per week and one hour for each session. Factors such as physiological cost index and walking speed were measured with the appropriate tools before and after training. The experimental groups of 1, 2 and 3 each did their own intervention, while the control groups received only stretching exercises. Analysis of data obtained from 96 patients studied was done using descriptive statistics and the analysis of covariance and paired comparing of the adjusted means (P<0.05).

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Results: A significant difference in walking speed or low-intensity failure of the first group ( p=0.000), moderate intensity or the second group (p=0.012) and severe and the third group (= p=0.000), in the experimental group were observed compared with the control group before and after exercise. In addition: significant differences was seen in PCI of patients with low disability intensity of the first group (p= 0.023), moderate intensity or the second group (p= 0.022) and severe or the third group (p= 0.0001), in the experimental group compared with the control group before and after exercise.

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Conclusions: Implementation of Rehabilitation exercises was affective on the comprehensive exercise on MS patients' recovery and reduced the physiological costs, and consequently improved the performance of walking in their physiological and reduced fatigue. According to the results, it is recommended that experts use these exercises as a complementary therapy alongside drug treatments for M.S patients.