1. Chilton W, O'Brien B, Charchar F. Telomeres, aging and exercise: guilty by association? IJMS 2017; 18(12): 2573.## [ DOI:10.3390/ijms18122573] [ PMID] [ ] 2. Coomans de Brachène A, Scoubeau C, Musuaya AE, Costa-Junior JM, Castela A, Carpentier J, et al. Exercise as a non-pharmacological intervention to protect pancreatic beta cells in individuals with type 1 and type 2 diabetes. Diabetologia 2023; 66(3): 450-60.## [ DOI:10.1007/s00125-022-05837-9] [ PMID] [ ] 3. Mthembu SX, Mazibuko-Mbeje SE, Ziqubu K, Nyawo TA, Obonye N, Nyambuya TM, et al. Impact of physical exercise and caloric restriction in patients with type 2 diabetes: Skeletal muscle insulin resistance and mitochondrial dysfunction as ideal therapeutic targets. Life Sciences 2022; 7: 120467.## [ DOI:10.1016/j.lfs.2022.120467] [ PMID] 4. Mehri A. Effect of 8 weeks aerobic training and supplementation of resveratrol on oxidative marker MDA and Antioxidant SOD and GPX cardiomyocytes tissue in streptozotocin-diabetic rats. Animal Physiology and Development 2020; 21;13(3): 97-108.## 5. Wang G. Aerobic exercise ameliorates myocardial ischemia/reperfusion injury and thrombosis of diabetic rats via activation of AMPK/Sirt1/PGC-1α pathway. General Physiology and Biophysics 2022; 1; 41(4): 319-28.## [ DOI:10.4149/gpb_2022010] [ PMID] 6. Rad RS. Effect of exercise and non-exercise interventions on cardiac angiogenesis in diabetes mellitus patients: a review. Int J Diabetes Endocrinol 2022; 7(1): 1-12.## [ DOI:10.11648/j.ijde.20220701.11] 7. Abdelsaid K, Sudhahar V, Harris RA, Das A, Youn SW, Liu Y. Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3. The FASEB Journal 2022; 36(3): e22177.## [ DOI:10.1096/fj.202101323R] [ PMID] [ ] 8. Fujie S, Sanada K, Hamaoka T, Iemitsu M. Time-dependent relationships between exercise training-induced changes in nitric oxide production and hormone regulation. Experimental Gerontology 2022; 166: 1-8.## [ DOI:10.1016/j.exger.2022.111888] [ PMID] 9. Abdehvand SZ, Dehkordi KJ, Taghian F. The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-2 gene expression in the heart tissue of myocardial infarction rats. Journal of Shahrekord University of Medical Sciences 2022; 24(1): 25-30.## [ DOI:10.34172/jsums.2022.05] 10. Sahafian M, Farzanegi P, Abbaszadeh H, Vizvari E. Effect of caffeine and genistein supplement on cardiac levels of nitric oxide and vascular endothelial growth factor in wistar rats, following an acute swimming exercise. Pathobiology Research 2018; 10; 21(1): 23-8.## 11. Hooshmand Moghadam B, Rashidlamir A, Attarzadeh Hosseini SR, Gaeini AA, Kaviani M. The effects of saffron (Crocus sativus L.) in conjunction with concurrent training on body composition, glycaemic status, and inflammatory markers in obese men with type 2 diabetes mellitus: A randomized double‐blind clinical trial. British Journal of Clinical Pharmacology 2022; 88(7): 3256-71.## [ DOI:10.1111/bcp.15222] [ PMID] 12. Su X, Yuan C, Wang L, Chen R, Li X, Zhang Y, et al. The beneficial effects of saffron extract on potential oxidative stress in cardiovascular diseases. Oxidative Medicine and Cellular Longevity 2021; 19: 1-14.## [ DOI:10.1155/2021/6699821] [ PMID] [ ] 13. G Gutheil W, Reed G, Ray A, Anant S, Dhar A. Crocetin: an agent derived from saffron for prevention and therapy for cancer. Current Pharmaceutical Biotechnology 2012; 13(1): 173-9.## [ DOI:10.2174/138920112798868566] [ PMID] [ ] 14. Hasanzadeh Dolatabadi F, Jalali Dehkordi KH, Taghian F, Hoseini SA. The effect of eight weeks of aerobic training with Propolis on some mitochondrial biogenesis markers in cardiac tissue of ovariectomized diabetic rats. Armaghane Danesh 2022; 27(2): 155-69.## [ DOI:10.52547/armaghanj.27.2.155] 15. Haghparast Azad M, Niktab I, Dastjerdi S, Abedpoor N, Rahimi G, Safaeinejad Z, et al. The combination of endurance exercise and SGTC (Salvia-Ginseng-Trigonella-Cinnamon) ameliorate mitochondrial markers' overexpression with sufficient ATP production in the skeletal muscle of mice fed AGEs-rich high-fat diet. Nutrition & Metabolism 2022; 19(1): 17.## [ DOI:10.1186/s12986-022-00652-w] [ PMID] [ ] 16. Zhang J, Wang Y, Dong X, Liu J. Crocetin attenuates inflammation and amyloid-β accumulation in APPsw transgenic mice. Immunity & Ageing 2018; 15(1): 1-8.## [ DOI:10.1186/s12979-018-0132-9] [ PMID] [ ] 17. Abdehvand SZ, Dehkordi KJ, Taghian F. The effect of eight weeks of interval training and quercetin nanoliposome supplementation on NF-κB and FGF-2 gene expression in the heart tissue of myocardial infarction rats. Journal of Shahrekord University of Medical Sciences. 2022 ;24(1):25-30.## [ DOI:10.34172/jsums.2022.05] 18. Eslamdoust M, Ghazalian F, Gholami M, Ebrahim K, Bazgir B. Response of serum levels of fibroblast growth factor-2 and transforming growth factor-β to eccentric resistance training with and without bfr in active young men. Sport Physiology & Management Investigations 2021: 13(2): 93-106.## 19. Chen G, Gulbranson DR, Yu P, Hou Z, Thomson JA. Thermal stability of fibroblast growth factor protein is a determinant factor in regulating self-renewal, differentiation, and reprogramming in human pluripotent stem cells. Stem Cells 2012; 30(4): 623-30.## [ DOI:10.1002/stem.1021] [ PMID] [ ] 20. Karnoub AE, Weinberg RA. Ras oncogenes: Split personalities. Nat Rev Mol Cell Biol 2008; 9(7): 517-31.## [ DOI:10.1038/nrm2438] [ PMID] [ ] 21. Sedighi M, Namdari M, Mahmoudi P, Khani A, Manouchehri A, Anvari M. An overview of angiogenesis and chemical and physiological angiogenic factors: short review. Journal of Chemical Health Risks 2022; 12: 1-15.## 22. Friedmann B, Frese F, Menold E, Bärtsch P. Effects of acute moderate hypoxia on anaerobic capacity in endurance-trained runners. Eur J Appl Physiol 2007; 101(1): 67-73.## [ DOI:10.1007/s00421-007-0473-0] [ PMID] 23. Silva R, D'Amico G, Hodivala-Dilke KM, Reynolds LE. Integrins: the keys to unlocking angiogenesis. Arterioscler Thromb Vasc Biol 2008; 28(10): 1703-13.## [ DOI:10.1161/ATVBAHA.108.172015] [ PMID] 24. Fathollahi Shoorabeh F, Faramarzi M, Hemmati R. The effect of 10 weeks of high-intensity exercise training on resting levels of some angiogenesis and pulmonary function of men with prostate cancer (Persian). J Fasa Univ Med Sci 2019; 8(4):1097-105.## 25. Krenc Z, Mazurowski W, Wosik-Erenbek M. Changes in VEGF and bFGF serum concentration after long-term sports training in young athletes - The significance of adaptive angiogenesis in arterial blood pressure adjustment. Pediatr Pol 2016; 91(6): 552-8.## [ DOI:10.1016/j.pepo.2016.09.009] 26. Ardakanizadeh M, Ranjbar K, Nazem F. The effect of ten factors of endurance activity on the gene expression of factors involved in the process of skeletal muscle angiogenesis after myocardial infarction in rats. Koomesh 2015; 19(1); 1-15.## 27. Kassab A, Piwowar A. Cell oxidant stress delivery and cell dysfunction onset in type 2 diabetes. Biochimi 2012; 94(9): 1837-48.## [ DOI:10.1016/j.biochi.2012.01.020] [ PMID] 28. Vettor R, Valerio A, Ragni M, Trevellin E, Granzotto M, Olivieri M, et al. Exercise training boosts eNOS-dependent mitochondrial biogenesis in mouse heart: role in adaptation of glucose metabolism. American Journal of Physiology- Endocrinology and Metabolism 2013; 306(5): 519-28.## [ DOI:10.1152/ajpendo.00617.2013] [ PMID] 29. Noraie F, Peeri M, Azarbayjani MA, Delfan M. The effects of eight weeks high intensity interval training on the levels of endothelial nitric oxide synthase(eNOS) gene expression in left ventricle of type 2 diabetic rats. Medical Journal of Tabriz University of Medical Sciences 2021: 17; 43(1): 100-7.## [ DOI:10.34172/mj.2021.034] 30. Bagherinia M, Abedi B, Fatolahi H. The effect of eight weeks of high intensity interval training on Let-7a, NO and VEGF levels in cardiac tissue of young rats with type 2 diabetes. KAUMS Journal (FEYZ) 2022: 26(1): 30-7.## [ DOI:10.34172/jsums.845] 31. Adela R, Nethi SK, Bagul PK, Barui AK, Mattapally S, Kuncha M, et al. Hyperglycaemia enhances nitric oxide production in diabetes: a study from South Indian patients. PloS one 2015; 10(4): e0125270.## [ DOI:10.1371/journal.pone.0125270] [ PMID] [ ] 32. Chen G, Zhang L, Van Schepdael A, Wang X. Recent advances in activation of endothelial nitric oxide synthase by natural products: an effects and mechanisms review. Food Reviews International 2023; 22: 1-6.## [ DOI:10.1080/87559129.2023.2166061] 33. Di Pietro N, Di Tomo P, Di Silvestre S, Giardinelli A, Pipino C, Morabito C, et al. Increased iNOS activity in vascular smooth muscle cells from diabetic rats: potential role of Ca2+/calmodulin-dependent protein kinase II delta 2 (CaMKIIδ2). Atherosclerosis 2013; 226(1): 88-94.## [ DOI:10.1016/j.atherosclerosis.2012.10.062] [ PMID] 34. Cai S, Khoo J, Channon KM. Augmented BH4 by gene transfer restores nitric oxide synthase function in hyperglycemic human endothelial cells. Cardiovascular Research 2005; 65(4): 823-31.## [ DOI:10.1016/j.cardiores.2004.10.040] [ PMID] 35. Guariguata L, Whiting DR, Hambleton I, Beagley J, Linnenkamp U, Shaw JE. Global estimates of diabetes prevalence for 2013 and projections for 2035. Diabetes research and clinical practice. 2014; 103(2):137-49.## [ DOI:10.1016/j.diabres.2013.11.002] [ PMID] 36. Kolluru GK, Bir SC, Kevil CG. Endothelial dysfunction and diabetes: effects on angiogenesis, vascular remodeling, and wound healing. International Journal of Vascular Mmedicine2012;1-30.## [ DOI:10.1155/2012/918267] [ PMID] [ ] 37. Grijalva J, Hicks S, Zhao X, Medikayala S, Kaminski PM, Wolin MS, et al. Exercise training enhanced myocardial endothelial nitric oxide synthase (eNOS) function in diabetic Goto-Kakizaki (GK) rats. Cardiovascular Diabetology 2008; 7(1): 34.## [ DOI:10.1186/1475-2840-7-34] [ PMID] [ ] 38. Cerdá-Bernad D, Valero-Cases E, Pastor JJ, Frutos MJ. Saffron bioactives crocin, crocetin and safranal: Effect on oxidative stress and mechanisms of action. Critical Reviews in Food Science and Nutrition 2022; 62(12): 3232-49.## [ DOI:10.1080/10408398.2020.1864279] [ PMID] 39. Pourmousavi L, Asadi RH, Zehsaz F, Jadidi RP. Effect of crocin and treadmill exercise on oxidative stress and heart damage in diabetic rats. BioRxiv 2023:16; 1-14.## [ DOI:10.1101/2023.02.01.526596]
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