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:: Volume 27, Issue 5 (8-2022) ::
__Armaghane Danesh__ 2022, 27(5): 0-0 Back to browse issues page
The association of anthropometric indices with renal function, serum fibroblast growth factor-23 (FGF23) and dephosphorylated-uncarboxylated matrix Gla-protein (MGP) levels in kidney transplant patients
Vahideh Ebrahimzadeh Attari1, Mohammad reza Ardalan2, Sima Abedi azar2, Jalal Etemadi2, Aida Malek Mahdavi 3, Arezoo Maddah2
1- Maragheh University of Medical Sciences
2- Tabriz University of Medical Sciences
3- Tabriz University of Medical Sciences , aidamalek@gmail.com
Abstract:   (43 Views)
Background and Objective:
Regarding that overweight and obesity are considered as an important risk factor for metabolic disorders, heart diseases and decreased kidney function in transplant patients, the present study aimed to investigate the association of anthropometric indices with kidney function and serum levels of FGF-23 and dp- ucMGP as cardiovascular disease risk markers in kidney transplant patients.
Methods: In this study, 90 kidney transplant patients aged 18-70 years with normal kidney function were selected from the clinic of Imam-Reza hospital, Iran, Tabriz during 6-12 months after transplantation. Anthropometric measurements including [weight, height, waist circumference, body mass index (BMI), and waist to height ratio] were obtained. Serum FGF-23 and dp-ucMGP levels were measured and glomerular filtration rate (GFR) was calculated as a kidney function index.  
Findings: The mean ± SD age was 44.10 ± 13.05 years and 59% were males. The means ± SD weight, BMI, waist circumference, and waist to height ratio were 69.61±11.59 Kg, 25.77±4.42 kg/m2, 94.07±15.48 cm, and 0.58±0.11, respectively. The prevalence of overweight and obesity was 38 % and 17%. The mean ± SD GFR was 57.45±12.61 ml/min/1.73 m2 and serum FGF-23 was 73.63±20.90 RU/mL. Median (interquartile range) dp-ucMGP was 2.40 (1.60, 3.20) µg/L. No significant correlation was observed between anthropometric measurements with GFR and serum levels of FGF-23 and dp-ucMGP (P>0.05). Significant negative correlation was found between serum FGF-23 and dp-ucMGP levels (P=0.036). Also, no significant correlation was observed between GFR with serum FGF-23 and dp-ucMGP levels (P>0.05).mouseout="msoCommentHide('_com_1')" onmouseover="msoCommentShow('_anchor_1','_com_1')">[M1] 
Conclusion: Considering that in the present study, the mean of weight and BMI was almost within the normal range, therefore, no significant correlation was observed between anthropometric indices and GFR and the serum levels of FGF-23 and dp-ucMGP. However, due to the importance of the problem and limited studies in this field, it is suggested that more studies be conducted with a larger sample size, especially longitudinal studies on overweight and obese patients, so that more accurate conclusions can be taken regarding the relationship between anthropometric indices and FGF-23 and dp-ucMGP serum levels in kidney transplant patients.

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Keywords: Anthropometric measurements, Weight, Body mass index, Kidney function, Fibroblast growth factor-23, dephosphorylated-uncarboxylated matrix Gla-protein, Kidney transplantation.
     
Type of Study: Research | Subject: Internist
Received: 2022/03/14 | Accepted: 2022/09/11 | Published: 2022/09/12
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Ebrahimzadeh Attari V, Ardalan M R, Abedi azar S, Etemadi J, Malek Mahdavi A, Maddah A. The association of anthropometric indices with renal function, serum fibroblast growth factor-23 (FGF23) and dephosphorylated-uncarboxylated matrix Gla-protein (MGP) levels in kidney transplant patients. ارمغان دانش. 2022; 27 (5)
URL: http://armaghanj.yums.ac.ir/article-1-3282-en.html


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Volume 27, Issue 5 (8-2022) Back to browse issues page
ارمغان دانش Armaghane Danesh
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