2024-03-28T19:17:26+03:30 http://armaghanj.yums.ac.ir/browse.php?mag_id=95&slc_lang=en&sid=1
95-1536 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 The Effect of Aqueous Extract of Mangrove Leaves (Avicennia marina) on Pituitary- Hormones of Gonadal Axis and Ovarian Follicle Numbers in Diabetic Rats R Rahbarian Rahbarian-ra@gmail.com SD Sadoughi damoon.sadughi@gmail.com H Esmaeili Sabzevar damoon.sadoughi@mshdiau.ac.ir ABSTRACT Background & aim: Reproductive disorders is one of the major issues in diabetic people and various chemical and herbal medicines has been used for its treatment. Due to the antioxidant and hypoglycemic properties of Avicennia marina, the aim of this study was to determine the effects of mangrove leaves aqueous extract on serum levels of hormones of pituitary- gonadal axis and ovarian follicle numbers in diabetic rats.   Methods: In the present experimental study, 32 female Wistar rats were allocated into equal groups of control, non-treated diabetic and two diabetic groups treated with mangrove leaves aqueous extract at concentrations of 100 and 200 mg/kg.  The diabetes in non-treated diabetic and treated diabetic groups with mangrove extract was induced using an intraperitoneal injection of 120 mg/kg alloxan. Aqueous extract of mangrove leaves were injected to treated diabetic groups, very other day for one month. Saline solution was injected to the animals of control and non-treated diabetic groups. At the end of exprement, serum levels of LH, FSH, estrogen, progesterone and prolactin were measured by ELISA. 5 µm sections of ovarian tissue were prepared and stained with Hematoxylin and Eosin. Then, ovarian follicle numbers were examined by light microscope. Data was analyzed using one-way ANOVA and Post Hoc Tukey statistical tests.   Results: Compared to control group, serum levels of LH, FSH, estrogen, progesterone and prolactin significantly decreased in non-treated diabetic group (p<0.05). Also, number of corpus luteum, primordial, primary, secondary and graph follicle significantly decreased and number of atresia follicle significantly increased compared to the control group (p<0.05). Compared to non-treated diabetic group, administration of mangrove leaves aqueous extract with concentrations of 100 and 200 mg/kg significantly increased serum levels of LH, FSH, estrogen, progesterone and prolactin (p<0.05). Also, number of corpus luteum, primordial, primary, secondary and graph follicle significantly increased and number of atresia follicle significantly decreased compared to non-treated diabetic group (p<0.05).   Conclusions: The results indicate significant effect of mangrove leaves extract on increases serum levels of gonadotropins, estrogen, progesterone and prolactin in diabetic rats. Also it has protective effect on ovarian tissue. Therefore, consumption of Avicennia marina could be effective in improving hormonal disorders and ovarian tissue damage in patients with diabetes.     Diabetes Ovary Avicennia marina Gonadotropin Gonadal Steroid Hormones Rat 2017 4 01 1 17 http://armaghanj.yums.ac.ir/article-1-1536-en.pdf
95-1623 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 The Effect Of Eight Weeks Of Combined Training And Garlic Supplementation On Adiponectin And Lipid Changes Among Inactive Boys A Jahantigh azamjahantigh2017@gmail.com R Delavar M Mogharnasi mogharnasi@birjand.ac.ir ABSTRACT   Background & aim: Nowadays, sedentary lifestyle has amplified health problems, such as an increased incidence of cardiovascular disease. This study examined the influence of eight weeks of combined training and garlic supplementation on changes in adiponectin and lipid in inactive boys.   Methods: In the present quasi-experimental study, 46 disabled boys were purposefully and voluntarily chosen to participate in research and were then randomly divided into four groups of supplement (n = 10), exercise + placebo (n = 13), exercise + supplement (n = 13) and control (n = 10). Fasting blood samples were taken after 8 to 10 hours, 24 hours before the start of practice and 48 hours after the last training session. Data were analyzed using the KS test, t-test, ANOVA and LSD test.   Results: Comparison between groups showed a statistically significant difference in level of adiponectin (p =0.01), triglycerides (p =0.03) and LDL-C (p =0.01). A significant difference at triglyceride levels between the control group and exercise + supplement (p=0.02), exercise + placebo and supplement (p=0.04) and exercise + placebo controls (p=0.01) were seen. Also, a significant difference at levels of HDL-C amonge groups exercise + supplementation and exercise + placebo (p=0.01), exercise + supplement and Control (p=0.01), exercise + placebo controls (p=0.01) and complementary and control (p=0.01) was observed respectively.   Conclusion: It seems that taking garlic supplements along with combination exercise can be one of the non-pharmacological methods to improve the level of adiponectin and lipid profile and effective in reducing cardiovascular risks.       Combined Training Garlic supplements Adiponectin Lipid Profiles 2017 4 01 18 31 http://armaghanj.yums.ac.ir/article-1-1623-en.pdf
95-1667 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 The Effect Of A Period Rhythmic Aerobic Exercise With Ginger Consumption On Serum Levels Of TNF-Α, IL-6 And Insulin Resistance In Obese Middle-Aged Women With Diabetes Mellitus M Asadi E Banitalebi banitalebi.e@gmail.com Z Esfadir M Ghafari ABSTRACT   Background & aim: Diabetes is a metabolic disorder associated with neuropathy, renal diseases, peripheral vascular disease, atherosclerosis, high blood pressure and inflammation. The use of supplements, herbal extracts, and exercise training for the treatment of diseases and metabolic disorders is common among people. The aim of this study was to investigate the effect effect of a period rhythmic aerobic exercise with ginger consumption on serum levels of TNF-α, IL-6 and Insulin resistance in obese middle-aged women with diabetes mellitus   Methods: In the present study, 46 obese diabetic women (BMI > 30, blood fasting sugar more than 150-250 mg/dL, 45-60 years old) were selected and randomly assigned into four groups including:  ginger (n=12), aerobic exercise training + ginger (n=12), aerobic exercise training (n=12) and control (n=10). Participants in supplementary groups received four 250 mg capsules ginger extract 1000 mg daily for 10 weeks. Aerobic training program included 10 weeks of training, 3 sessions per week and each session was 60 minutes at 55% maximum heart rate during the first week and gradually increased with the progress of the training program to 75 percent of maximum heart rate. Each session consists of warm up (10 minutes), the main part of the training involves performing aerobic exercises in a standing position (40 minutes) and recovery in sitting (10 minutes).   Results: No significant difference between four groups at level of TNF-α and IL6 was seen, but a significant degrease was observed between pre-test and post-test in (Training + ginger) group at levels of TNF-α (p=0.028), IL-6 (p=0.012), insulin resistance (p=0.009), insulin (p=0.007) and fasting serum glucose (p=0.000),   Conclusion: According to obtained results, it appeared that aerobic training plus ginger extract consumption had better effect on serum inflammatory factors in obsess women with diabetes              type 2.     Rhythmic aerobic training Diabetes mellitus TNF-α IL-6 Ginger 2017 4 01 32 47 http://armaghanj.yums.ac.ir/article-1-1667-en.pdf
95-1724 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 The effect of Training Emotional Regulation on Impulsivity and Styles of Decision-Making Among Female Prisoners in Yasuj, Iran Z Sadatnadab Kh Ramezani kh.ramezani@gmail.com ABSTRACT   Background and aim: Emotional failure and inefficient styles of decision making tend to create a number of difficulties in everyday life with long lasting effects. This failure for prison inmates, especially the female ones, is more critical and palpable. This study aimed to teach emotional regulation on impulsivity and styles of decision-making among the female prisoners in Yasuj.   Methods: In the present trial-clinical and interventional study, the sample included 30 female inmates who voluntarily participated in the study and were randomly assigned to experimental and control groups. The experimental group underwent an eight-session Grass-based emotional regulation skills training program, but the control group received no intervention. Subsequently, the training and control groups were given pretest and posttests. The instruments consisted of Barratt’s Impulsiveness and Scott and Bruce’s decision making styles questionnaire. Data were then analyzed using SPSS version 22.   Results: The findings showed the effect of emotional regulation training program on reducing overall (P<0.05), cognitive (P<0.001), behavioral (P<0.05), and unplanned (P<0.05) impulsivity among the female prisoners. The program also increased rational (P<0.001) and intuitive (P<0.01) decision making styles among the participants. Likewise, the intervention had a significant impact on reducing the avoidance (P<0.05), dependent (P<0.05) and immediate (P<0.05) decision making styles.   Conclusion: According to the results, since the teaching of the emotional regulation reduces impulsivity and increases styles of rational decision making among the prisoners,  it should be noted that professional communication in the form of emotional regulation training can result in the enhancement of knowledge and skills in controlling the negative impulsivity styles and increase rational decision.     Emotional regulation Impulsivity Decision making styles Prison 2017 4 01 48 60 http://armaghanj.yums.ac.ir/article-1-1724-en.pdf
95-1443 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 The effect of Regular Aerobic Exercise Along with Vitamin C Consumption on Homocysteine levels and Insulin Resistance in Obese Girls M Habibian habibian_m@yahoo.com P Farzanegi parvin.farzanegi@gmail.com B Asadi behinasadi@yahoo.com ABSTRACT   Background and aim: Childhood obesity is associated with an increased risk of cardiovascular complications and multiple metabolic such as insulin resistance and hyperhomocysteinemia. The aim of this study was to investigate the effect of regular aerobic exercise along with vitamin C consumption on the homocysteine levels and insulin resistance in obese girls.   Methods: In the present semi-experimental study, 28 obese girls aged 8 to 12 years and body mass index 95% were selected and randomly divided as follow: control, exercise training, vitamin C and exercise training+ vitamin C (combined) groups. Aerobic exercise was consisted of exercise movements at 50% to 70% maximal heart rate and 3 sessions per week for 8 weeks. Vitamin C and combined groups consumed 500mg vitamin C tablets every other day. Fasting blood samples were collected before and 48 hour after the last intervention. For statistical analysis, One Way Analysis Variance (ANOVA), post hoc Tukey and independent t-test were used.   Results: Eight weeks of aerobic exercise, vitamin C and the combined intervention were resulted a significant decrease in the levels of glucose, insulin, homocysteine and insulin resistance in obese girls (P<0.05). Furthermore each of three interventions was associated with a significant percent changes in these veraibles compared with control group. But the effect of combined intervention on the decrease in these variables were greater compared with other interventions (p<0.05).   Conclusion: These findings suggested that both of aerobic exercise and vitamin C consumption non-drug can cause down regulation of homocysteine and insulin resistance levels in obese girls. Thus, the combined effect of regular aerobic exercise and vitamin C intervention is associated with the augmentation of these effects.     Aerobic exercise Homocysteine Insulin Resistance Vitamin C. 2017 4 01 61 74 http://armaghanj.yums.ac.ir/article-1-1443-en.pdf
95-1663 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 Comparison of Psychological Flexibility in Patients with Irritable Bowel Syndrome in Normal Counterparts F Jahangiri jahangirifarhad3@gmail.com J Karimi jaahangirifarhad3@gmail.com MR AminAfshari jaahangirifarhad3@gmail.com     Background & aim: Psychological flexibility is a major component of health-related behaviors and refers to ability to get in touch with the present moment and insist on behavior modification in line with personal values. The purpose of this study was to comparing psychological flexibility in patients with irritable bowel syndrome and normal control group.   Methods: In a case-control study 61 patients with irritable bowel syndrome which were referred to gastroenterologist in Boroujerd, were selected via convenience sampling and compared with normal control group in psychological flexibility. Acceptance and Action Questionnaire (AAQ), Cognitive Fusion Questionnaire (CFQ), Mindful Attention Awareness Scale (MAAS) and Meaningful Live Questionnaire (MLQ) were used as research tools. Independent t test was used for data analysis.    Results: The results showed that the difference between the two groups in terms of acceptance (p <0.006), mind-consciousness (p <0.001) and life based on internal values (p <0.006) is significant, as the band syndrome irritable bowel compared to the normal group received lower scores. In cognitive fusion (P <0.014) difference between two group was significant, so that the patient group achieved the higher scores. Both this findings mean lower psychological flexibility in individuals with irritable bowel syndrome.     Conclusions: According to this study, patients with irritable bowel syndrome had lower levels of psychological flexibility than normal group and it can effective in initiating or exacerbating their symptoms.     Irritable Bowel Syndrome Psychological Flexibility Acceptance Mindfulness 2017 4 01 75 86 http://armaghanj.yums.ac.ir/article-1-1663-en.pdf
95-1652 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 Comparing the Effectiveness of Cognitive Behavioral Therapy and Hypnosis Therapy Pain Self-Efficacy and Pain Severity in Girls with Primary Dysmenorrhea F Farshbaf Manei Sefat maneisefat@yahoo.co.in A Abolghasemi Abolghasemi1344@guilan.ac.ir U Barahmand ub@uma.ac.ir N Hajloo hajloo53 @uma.ac.ir ABSTRACT   Background & aim: Menstruation as an important issue in adolescence and menstrual pain is a common problem in adolescents. Regarding the relationship between pain severity and  pain self-efficacy, this study aimed to investigate and compare the efficacy of cognitive-behavioral therapy and hypnosis therapy on pain and pain self-efficacy in girls with primary dysmenorrhea.   Methods: The method of research is Quasi experimental and research design is pretest- posttest with control group. The study population included all second high school girls with primary dysmenorrhea in Ardabil city on 2015. a sample of 1,600 girls was screened by multi-stage cluster sampling method. After checking of entry criteria, 75 of those were assigned in 3 groups (two experimental groups and one control group) randomly. Self-efficacy questionnaire, visual analogue and scale Researcher- made questionnaire was used for collection data in pre-test and post-test stage. In order to collect data on pre and post grading, visual analog scale pain self-efficacy and self-administered questionnaire was used. For experimental groups, Pain control training based on cognitive-behavioral approach and self-hypnotism training was executed at 10 sessions in 45 minutes whereas control groups was in waiting list. Data collected were analyzed by descriptive statistics (mean and standard deviation) and multivariate analysis of covariance, Kruskal-Wallis and Mann-Whitney U.   Results: According to the chi Eta in one way covariance analysis The effectiveness of therapies on pain self-efficacy was 49 percent. There was no significant difference between cognitive behavioral group and hypnotherapy on pain self-efficacy justified mean with Bonferroni correction but there was significant difference between cognitive behavioral group and control group and between hypnotherapy group and control group on pain self-efficacy justified mean. The results of Kruskal Wallis showed that there is significant difference between 3 groups in pain severity. For comparison amongs groups, U-Mann Whitney index showed that the pain severity reduced significantly in cognitive behavioral and hypnotherapy group compared with control group and hypnotherapy which is More effective than cognitive behavioral therapy.   Conclusion: Cognitive behavioral therapy and hypnotherapy are effective in increased pain self-efficacy and reducing pain severity in girls with primary dysmenorrhea.   Cognitive Behavioral Therapy Hypnotherapy Pain Self-Efficacy Pain Severity Primary Dysmenorrhea 2017 4 01 87 103 http://armaghanj.yums.ac.ir/article-1-1652-en.pdf
95-1601 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 Single Nucleotide Polymorphisms of MMP2 Gene Promoter on the Risk of Development and Metastasis of lung Cancer H Keshvary Ravan javadi1323@yahoo.com F Kouhkan biology1991@yahoo.com H Sazgar u8002010@hotmail.com     Background & aim: The high incidence and poor prognosis of the lung cancer makes it aa a major health problem in the last few decades. Determination of frequency of different histopathology types of primary lung cancer has great importance in creating integrated treatment programs and recognized the effective factors causing the disease. Overexpression of MMPs has a direct relation with invasion and metastasis of malignant tumors in different tissues. The aim of this study was to assess the effect of MMP-2 gene promoter polymorphism with lung cancer and metastases in patients with lung cancer and compared with the control groups by the PCR-RFLP method.   Methods: In the present case-control study, The MMP-2 polymorphisms were analyzed by restriction fragment-length polymorphism (RFLP) in 50 patients with lung cancer and 77 cohort sample. All samples were taken under supervision of a physician. DNA isolation was performed using DNA extraction kit (Cinnagen, Iran). MMP9 gene was amplified by specific primers and PCR product was digested with FSPBI restriction enzyme. Data were analysis using Chi square by the SPSS software.   Results: The examination of allelic and genotypic distribution in patients with lung cancer and control showed that the allele frequency of C and T in patients with lung cancer were 90 and 10% (P=0.04) and in the control were 80.15 and 30% (P=0.05) respectively. Also genotype frequency of CC, CT and TT in patients with lung cancer were 82, 16 and 2 (P=0.05) and in the control were 69.93, 31.16, 3.1 percentage respectively (P=0.5). No significant difference was seen in comparison of genotype groups in non-metastatic and control. Comparison of homozygous CC genotype and control were confirmed the direct involvement of c allele in metastasis   Conclusion: It seems that individuals with C allele can increase susceptibility to lung cancer. Also these findings indicate that CC genotype as a risk factor facilitating the spread of metastasis of lung cancer.   Lung cancer Matrix metalloproteinase MMP-2 PCR RFLP 2017 4 01 104 117 http://armaghanj.yums.ac.ir/article-1-1601-en.pdf
95-981 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 The Evaluation of Microorganisms and Risk Factors of Neonatal Sepsis in Patients with Suspected Sepsis in Imam Sajjad Hospital, Yasuj A Keshtkari a_keshtkari@yahoo.com GH Parsa gshr3@yahoo.com HR Ghafarian Shirazi Drghparsa45@yahoo.com P Koleini p.kpleini@yahoo.com ABSTRACT   Background & aim: Nowadays, despite the emergence of newer antimicrobial agents, sepsis remains as a major cause of mortality and disease in neonates. Sepsis is an infection proven by blood culture that can be created from various sources in admitted neonates and increased length of stay, impose heavy costs on the health system and be more pathogenic; therefore, is very important in clinical studies. The aim of this study was to investigate the causative organisms involved in sepsis and risk factors for neonatal infection.   Methods: This longitudinal analytic study was done in duration of 8 months on 100 neonates with suspected late-onset sepsis in the neonatal and NICU ward of Imam Sajad Hospital of Yasuj, Iran. The neonates’ blood cultures and risk factors involved in sepsis were evaluated. Due to negative blood cultures obtained, patients with a clinical syndrome SIRS criteria were considered as suspected cases of late sepsis. Chi-square test was performed for the association between potential risk factors and severity of nosocomial infections. Collected data were analyzed using SPSS software and Chi-square test.   Results:از میان کشت ‌های خون فرستاده شده از بیماران که 61 ‌( ‌ ‌% ‌) ‌مورد پسر و 39 ‌( ‌ ‌%)مورد دختر بودند، ‌بجز یک مورد کشت خون مثبت اولیه با استافیلوکوک ارئوس ‌، ‌هیچ کشت خون مثبتی گزارش نشد. ‌از میان بیماران انتخاب شده 57 مورد ‌(57 ‌% ‌)، ‌کمتر از 37 هفته و 43 مورد ‌( ‌ ‌% ‌) ‌بیشتراز 37 هفته بودند که در‌این بیماران ،نارس ی ارتباط معنی داری ‌( p‌=‌ ‌‌) ‌از نظر ابتلا به سپسیس داشت. ‌از میان بیماران هنگام بستری 78 مورد ‌( ‌ ‌% ‌)، ‌سن بستری کمتر از 24 ساعت داشتند که ارتباط معنی داری ‌( ‌= 0.01 ) Of 100  culture samples  only 1 positive blood culture with Staphylococcus aureus was identified. SIRS syndrome was confirmed in 61 patients, of which 47 cases with two criteria and 14 cases were diagnosed with three criteria in this clinical situation. In the statistical analysis, patient examination more than three times in 24 hours (P = 0.026) had significant statistical correlation with SIRS criteria in neonates. . Conclusion: In hospitals that employ of artificial media to identify the blood culture proven sepsis should be not satisfied as the only way out. The most important risk factor for late-onset sepsis in this study, high contact with patients for clinical examination is presented.    .   Neonate Sepsis SIRS syndrome Risk factors 2017 4 01 118 128 http://armaghanj.yums.ac.ir/article-1-981-en.pdf
95-1628 2024-03-28 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2017 22 1 The Protective effect of Hydro-Ethanolic Extract of Tragopogon Pratensis Leaves on Liver of Male Rats Receiving Lead Acetate A Hoseini info.azadeh.hoseini@gmail.com H Vazini hossein_vazini@yahoo.com N Mirazi mirazi205@gmail.com ABSTRACT   Background & aim: Some  natural  and synthetic compounds have antioxidant properties which protect the liver tissue against  toxins  such as lead. they also plays an important role in reducing the harmful effects of heavy metals and pesticides. The aim of this experimental study is to investigate the protective effects of Tragopogon pratensis leaves extract (TPE) in male rats.  Methods: In this study 36 male Wistar rats weighing 220±250g  were randomly divided into six groups: control group, toxicant group received 0.5g/L lead acetate in tap water, treatment groups (1,2 and 3: received 0.5gr/L lead acetate in tap water and 200,400,800 mg/kg TPE ) respectively. positive control received 400mg/kg TPE gavaged . At the end of examination the blood samples were collected and liver enzymes, total protein, albumin, MDA, total bilirubin and direct bilirubin were analyzed. The data were analyzed by SPSS software and one-way ANOVA and Tukey´s test.   Results: Serum levels of liver enzymes (AST, ALT, ALP) increased significantly in the acetate group compared with the control group (P<0.001).The serum levels of albumin and total proteins were reduced and MDA was increased significantly compared with control group (P<0.001). The serum levels of liver enzymes were reduced significantly in treatment groups compared with toxicant group (P≤0.001). Conclusion: The effective ingredients in Tragopogon pratensis extract  are probably due to the presence of antioxidant compounds reduce the production of released radicals which can stabilize the membrane of the hepatocyte membrane and reduce the release of liver enzymes in the blood. Lead acetate liver enzymes Tragopogon pratensis rat 2017 4 01 129 144 http://armaghanj.yums.ac.ir/article-1-1628-en.pdf