2024-03-29T00:02:03+03:30 http://armaghanj.yums.ac.ir/browse.php?mag_id=87&slc_lang=en&sid=1
87-1194 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 The Effects of Aqueous Extract of Wild Pistachio (Pistacia Atlantica) leaves on Diabetic Nephropathy in Rat KH Vazifeshenas-Darmiyan M Hosseini R Rezaei S Ezi M Malekaneh drmalekaneh@yahoo.com Background & aim: Due to increased public interest in the use of herbal medicine, their efficacy and safety evaluation have become important. In some studies, Pistacia atlantica leave (PAL) extract suggested as a hypoglycemic agent. However, there is no study about its effects on diabetic nephropathy. Therefore, the present work was conducted to evaluate the effects of aqueous extract of PAL on some biochemical and pathological aspects related to renal function in diabetic rats. Methods: In the present experimental study, 40 severe diabetes male Wistar rats (180-200 gr) with STZ and eight healthy rats at the same age were equally divided into 6 groups and followed for a period of thirty days as the oral treatment respectively. Diabetic groups I ,II and III received 100, 200 and 400 mg/kg of PAL extracts, diabetic group IV received 50 mg/kg Captopril and diabetic group  V and healthy group received saline 0.9% as control groups. Finally, fasting blood glucose (FBG), Urine volume and 24 h urine total protein (UTP), blood nitrogen urea (BUN) and plasma creatinine (Cr) were assessed biochemically and also qualitative renal histomorphological alterations were assessed pathologically. Data were analyzed using one-way ANOVA and Tukey post hoc test. Results: In diabetic control group the FBS (383.5 ± 118.33), BUN (27.17± 2.86), Cr (1.3 ± 0.45), Urine volume (24.66± 5.10) and UTP (25.67 ± 1.51) of groups 1-5 significantly increased in comparison whit normal control group (p<0.0001 each). In addition:  severe glomerolosclerosis, mesangial matrix expansion and tuft-capsule adhesion were observed in diabetic rats. Unlike captopril, which could significantly reduce the mean level of urea nitrogen (p <0.001; 12.5 ± 2.81), creatinine (p=0.034; 0.97±0.14) and protein (p=0.002: 13.66 ± 3.48) compared with diabetic controls the histology of the group was evaluate and confirmed its moderator effects, Conclusion: The results clearly demonstrate that PAL did not have any beneficial effects on diabetic nephropathy in rats. Pistacia atlantica Captopril Diabetic Nephropathy Rat 2016 8 01 420 434 http://armaghanj.yums.ac.ir/article-1-1194-en.pdf
87-1316 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 The Effect of Propiconazole and Protective Effects of Selenium Gene Expression Profile of Caspase 9 in the Testicular Tissue of Male Sprague Dawley (SD) Rats S Rashidi pouya H Mohseni kouchesfehani kouchesfehani@yahoo.com SA Angaji Background & aim: Conazoles including imidazoles or triazoles are anti- fungal agents widely used to prevent fungal growth and their infections. Propiconazole placed in this group is a systemic fungicide used widely for detoxification of cereal seeds especially rice in Iran and other countries. This fungicide were designed to inhibit a specific cytochrome P450, CYP51 (lanosterol-14-α- demethylase), a critical step in the biosynthesis of ergosterol, a steroid required for the formation of the fungal cell wall. In the present experimental study, the effect of propiconazole on Caspase 9 gene expression profile as an initiator of apoptotic process and protective effect of selenium were investigated. Methods: Forty SD rats were divided into 10 groups of 4,  including : control , sham1 (solvent of propiconazole, distilled water), sham 2 (solvent of selenium, normal saline) and 1 group received 0.5 mg/kg selenium ,3 groups received propiconazole in doses of 10,50,75  mg/kg and 3 groups received propiconazole in doses of 10,50,75 mg/kg propiconazole with 0.5 mg/kg of selenium. Injections were intrapritoneal for two weeks in alternate days. Then, using RT-PCR and Total Lab program gene expression of caspase-9 testicular of all groups were studied. Data were analyzed using descriptive statistics. Results:  A significant increase of caspase 9 expression were observed among all experimental groups compared to control and sham groups. These findings indicated that 0.5 mg/kg selenium is not a suitable dose to create protection in this experimental study.  Conclusion: The significant increase in Caspase 9 gene expression profile observed in all experimental groups as compared to control suggests activation of apoptosis and inefficacy of selenium to protect the testis against induced damages. Apoptosis CASP 9 Propiconazole SD rat Selenium 2016 8 01 435 445 http://armaghanj.yums.ac.ir/article-1-1316-en.pdf
87-1330 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 The Effect of the Hydroalcoholic Extract of Dill ( Anethum graveolens( Seed on Lipid Profile in Diabetic Male Rats M Askari H Nazari knazari66@yahoo.com SH Rahimizadeh H Sadeghimansorkhani NA Daneshpayeh Background & aim: Nowadays, Diabetes is prevalent in different societies, and hyperlipidemia is one of the important outcomes and effective in the development of complications from this disease. Therefore, finding a medication to reduce hyperlipidemia without an adverse effects on blood sugar levels has always been investigated. Some studies have been reported the beneficial effects of the aerial parts of Anethum graveolens on lipid levels in the clinical and animal models. As there is no study on the effect of dill seed extract on blood lipid levels in diabetic rats; the aim of this study was to evaluate the effect of the dill seed extract on lipid profile in diabetic rats. Methods: In this experimental study, 24 rats with a weight range of 200 to 250 g were randomly divided into three groups of eight, including normal group, diabetic group (received normal saline) and diabetic group (received seed extract to 100 mg /kg). To induce diabetes, the rats were received streptozocin (50 mg /kg,) intraperitoneally. The dill seed extract was given for four weeks and then the blood samples were collected to measure LDL, HDL and triglyceride. The differences between the control and treatment groups were tested by one-way analyses of variance (ANOVA) followed by the Tukey post-hoc test. Results: Induction of diabetes significantly increased the serum concentration of LDL and triglycerides compared with the control group (p=0.001), but no effect was seen on HDL levels. Dill Oral administration of seed extract-dose (100 mg/kg) animal serum concentration of LDL significantly reduced in comparison with diabetic group (p=0.001). The triglyceride serum levels was significantly reduced compared to diabetic group after 4 weeks administration of dill seed extract (p<0.001), but no effect was observed on HDL in comparison to diabetic group (p=0.54). Conclusion: The results showed that the dill seed extract was able to reduce the serum levels of LDL and triglyceride in the diabetic rats. So it seems that this extract can reduce cardiovascular complications of diabetes through reducing the blood lipid profile. LDL HDL triglycerides diabetes Dill seeds Rats 2016 8 01 446 454 http://armaghanj.yums.ac.ir/article-1-1330-en.pdf
87-1269 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 Molecular Detection of Mycoplasma Pneumoniae Using P1 Gene in Patients With Chronic Obstructive Pulmonary Syndrome S Amirian K Amini kamini@iau-saveh.ac.ir M Parviz Background & aim: Chronic obstructive pulmonary disease (COPD) is a chronic lung disease characterized by irreversible progressive obstruction of the airways which occur in three forms including; emphysema, chronic bronchitis, and small airways disease. Mycoplasma pneumoniae causes respiratory problems such as sore throat, pharyngitis, tracheobronchitis and other respiratory infections, especially in patients with COPD. Conventional methods for detection of M. pneumoniae have restrictions so that, the use of a reliable and sensitive method is essential. Therefore, the aim of this study was to identify Mycoplasma pneumoniae in respiratory secretions of patients with COPD by PCR method. Methods: In the present cross-sectional study, a total of 120 respiratory secretions samples were collected from patients with COPD during a one year duration (2014-2015).  Bacterial identification was performed by the PCR method and confirmed by DNA sequencing. Collected data were analyzed by cross-sectional analysis. Results: The most occurrence of Mycoplasma pneumoniae respiratory infections was in the age group of 4-21 years and the lowest rate was presented in the age group of 0 to 3 years. The results also indicated that of the collected 120 samples, 8 samples (6.6%) were positive for Mycoplasma pneumoniae and carried the P1 gene. These high rates of infection with these types of Mycoplasma were indicated in patients with chronic obstructive pulmonary syndrome. Conclusion: The results of the present study revealed that Mycoplasma pneumoniae can be one of the factors likely to develop COPD. The PCR method used with specific primers was able to detect Mycoplasma pneumoniae in respiratory secretions. This may facilitate the treatment portion of patients with symptoms of COPD. Mycoplasma pneumoniae Multiplex PCR Chronic Obstructive Pulmonary Syndrome. 2016 8 01 455 464 http://armaghanj.yums.ac.ir/article-1-1269-en.pdf
87-1201 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 Returning to life, the Lived Experiences of Pregnancy in Women with HIV: A Phenomenological study Z Khalajinia zkh6033@yahoo.com A Nikbakht Nasrabadi Z Behboodi-Moghadam P Yadollahi M Abbasi Background & aim: Pregnancy is every woman's stage of life. During this period, women experience physical, mental and social changes. It is very sensitive, challenging and therefore a critical period for every woman particularly in HIV-positive women. During pregnancy, an HIV-positive mother is facing a psychological crisis which includes fear of transmission to children, death, leaving children to the family or a guardian, adverse effects during pregnancy and the effects of pregnancy on their health. Therefore, HIV-positive pregnant women are vulnerable and require supportive interventions.  Care for pregnant women with HIV negative women are unique and different. However, no more information about experience of pregnancy in HIV positive women exists. Therfore, the aim of the present study was to explore the lived experience of pregnancy in HIV-positive women. Methods: The present qualitative study with hermeneutic phenomenological approach included 12 HIV-infected pregnant women who referred to the counseling center for behavioral diseases at Imam Khomeini Hospital of Tehran University of Medical Sciences who were recruited through purposive sampling. Data were collected through semi-structured interviews. Data saturation was achieved after 16 interviews, each 40 to 90 min of duration with participants and then was analyzed by the method proposed by Diekelmann (1989). Results: The participants in the present study were of 22- 39 years of age. After data analysis, the main themes and 3 sub-themes emerged. These themes included: “return to life” with the three sub-themes of experience of motherhood, stability and protection, and gratification. Conclusion: The results revealed that although the experience of pregnancy in HIV-positive women was associated with a deep sense of fear of transmission of the disease and having children was viewed as a way of hope. Motherhood gave their lives meaning and provided for them to return to life. Understanding and awareness of all those are necessary for health care providers.The findings of this study emphasize on the need to design and implement comprehensive prevention strategies and interventions tailored to have a good feeling of pregnancy in these women. Pregnancy HIV-positive women Phenomenology Qualitative Study 2016 8 01 465 480 http://armaghanj.yums.ac.ir/article-1-1201-en.pdf
87-1347 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 Comparison of Endurance Training and Overtraining on the Balance of Th1 / Th2 in Male Wistar Rats O Salehian R Soori soorirahman@yahoo.com AA Ravasi S Choobine Background & aim: The immune system is involved in numerous activities including inflammatory and anti-inflammatory activities. The activities associated with the production of Interferonγ and Interleukin-4. The present study investigated the effect of endurance training on the balance of these two cytokines pays more. Methods: In the present study, 30 rats were selected and divided into 3 groups of 10: control, endurance and overtraining exercise. Endurance training protocol and overtraining were done for 12 weeks. Endurance training was done with the speed of 10 m/min in first week and 23m/min in last week. Overtraining protocol was done with the speed of 15 m/min in first week and 25 m/min in last week. Speleenectomy was done after interval training protocol, and then Interleukin 4 (IL4) and Interferon γ (IFNγ) were evaluated by the Eliza method. One-way ANOVA and Tukey post hoc test was used for data analysis. Results: The results showed a significant increase in the amount of (IFNγ) and a decrease in the levels of IL4 in endurance training group (p=0.01). The results also exposed an increase in levels of IL4 and decrease IFNγ levels in overtraining group which was significant (p=0.01). Conclusion: It can be concluded that the response to endurance training the amount of IFNγ and in response to overtraining the level of IL-4 was increased. endurance training overtraining IFNγ IL4 2016 8 01 481 491 http://armaghanj.yums.ac.ir/article-1-1347-en.pdf
87-1357 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 The Effectiveness of Resiliency based on Islamic Spirituality Training on Mental Health and Spiritual Resiliency among Mothers of Slow Pace (Mentally Retarded) Children SH Bakhshizadeh sh.bakhshizadeh@yahoo.com GH A Afrooz A Beh-pajooh B Ghobari Bonab M shokoohi Yekta Background & aim: Birth and presence of slow pace children in each family can be considered as challenging and adverse event that probably leads to stress and frustration and mental health related complications. According to several studies that show positive and significant relationship between resiliency and values and religious beliefs and their impact on mental health,the present study was conducted to evaluate the effectiveness of resiliency skills training based on Islamic spirituality in promoting mental health and spiritual resilience among mothers of Slow Pace children. Methods: The present study used a semi-experimental design with pre test-post test which was conducted among mothers of Slow Pace Children in Dehdasht, Iran, and the countryside using random sampling, in which 30 of these mothers were randomly divided into two experimental and control groups, participated in this study. Twelve sessions of resiliency training based on Islamic spirituality were held for experimental group of 15 people.The tools used in this study included a mental health questionnaire-28 (Ghq) and resiliency based on Islamic spirituality researcher made scale that were completed by individuals in pre and post tests. Finally, collected data were analyzed by multivariate analysis of covariance (MANCOVA). Results: Analysis of data using multivariate analysis of covariance showed that utilization of Intervention program among mothers of Slow Pace children in experimental group was significantly (P>0/05) effective on mental health and components of resiliency based on Islamic spirituality. In other words, spiritual resiliency skills training was led to improve depressive symptoms, social functioning and components of spiritual resiliency such as patience, contentment, Submission and thanksgiving. Conclusion: The results of the present study indicated that through changes in attitude of Slow Pace children's mothers, resiliency skills training based on Islamic spirituality can improve mental health and components of resilience-based on Islamic spirituality and helps them keep their mental health despite the exposure to chronic stress and tension. mothers of Slow Pace Children Resiliency based on Islamic Sprituality Training Mental Health. 2016 8 01 492 512 http://armaghanj.yums.ac.ir/article-1-1357-en.pdf
87-1169 2024-03-29 10.1002
Armaghane Danesh armaghanj 1728-6506 1728-6514 10.61186/armaghanj 2016 21 5 A case Report of Human T-cell lymphotropic Virus Type 1(HTLV1) Infected Virus with Similar Multiple Sclerosis Symptoms in a Non-endemic Area A Moghadam Ahmadi E Ranjbar Elham.ranjbar71@yahoo.com M Irannezhad Background & aim: Human lymphotropic retrovirus type 1( HTLV1) is the first known virus which could cause serious diseases such as adult leukemia- lymphoma T-cell lymphoma (ATL) and Tropical Spastic (TSP). On the other hand, due to the HTLV1 similarity symptoms in patients with multiple sclerosis symptoms in Khorasan as the region's endemic, knowledge and understanding of the virus and the disease is necessary in other areas as well. The aim of the present case report study was to investigate the HTLV1 infected virus with similar multiple sclerosis symptoms in a Non-endemic area. Case presentation: The patient in the present case report study was a 56 years old women which her illness was early diagnosed as MS (multiple sclerosis).  No sign of improvement in therapy period was observed. Therefore, due to limited symptoms in lower extremities and sphincter dysfunction, her serum and cerebrospinal fluid for the presence of antibodies anti HTLV1 was evaluated. The presence of Abs with clinical symptoms, cause diagnosis of the virus in the patient. Conclusion: This patient was referred with symptoms of progressive paraparesis spatic and at first her disease was mistakenly diagnosed as MS.  Due to lack of response to treatment and atypical clinical symptoms related to MS and Khorasan province after two years the patient was diagnosis as HTLV1. It is recommended to apply differential diagnosis of MS in specific geographic regions, such infection  as HTLV1 especially in endemic areas should be considered. HTLV1 Multiple Sclerosis Spastic Paresis 2016 8 01 513 520 http://armaghanj.yums.ac.ir/article-1-1169-en.pdf