Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
Impact of Oral Zinc Sulfate on Uncomplicated Neonatal Jaundice
460
471
FA
SH
Nabavizadeh
Pediatrics Medicine department, Shiraz University of Medical Sciences, Shiraz, Iran
N
K
Keshavarz
Social Determinants of Health Research Center, Yasuj University of Medical Sciences, YasuJ, Iran
N
SMH
Sadati
Social Determinants of Health Research Center, Yasuj University of Medical Sciences, YasuJ, Iran
N
H
Abidi
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, YasuJ, Iran
N
A
Poursamad
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, YasuJ, Iran
N
M
Zoladl
Cellular and Molecular Research Center, Yasuj University of Medical Sciences, YasuJ, Iran
zoladl.mohammad@yums.ac.ir
Y
Background & aim: Jaundice is one of the most significant problems to consider in the neonatal period. The aim of this study was to determine the impact of oral zinc sulfate on uncomplicated neonatal jaundice using comparison of effect of just phototherapy with the effect of combination of phototherapy and oral zinc sulfate.
Methods: The present double blind randomized clinical trial was carried out on 78 normal term neonates with the age of 2-7 days who were admitted for uncomplicated jaundice in neonatal ward of Imam Sajjad Hospital of Yasuj University of Medical Sciences. These infants were divided to experimental group (40 cases) and control group (38 cases) using block random allocation. In the control group, phototherapy was done alone and experimental group received elemental zinc orally as 10 mg daily for 5 days in combination with phototherapy. The total bilirubin serum levels were measured at the beginning of the study , 6 hours, 12 hours, and 24 hours after the beginning of the study, discharge, and one week after discharge. The collected data were analyzed by the Chi Square test, independent t-test, and analysis of variance with repeated measurement.
Results: There were no significant statistical difference between the experimental group and control group in sex, age, birth weight, hemoglobin, reticulocyte percentage, G6PD deficiency, and of serum total bilirubin level at the beginning of study(p>0.05). Analysis of variance with repeated measurement showed that there were no significant statistical difference between the total bilirubin serum level at 6 hours, 12 hours, 24 hours after beginning of the study, discharge, and one week after discharge (p>0.05). Also, the mean of hospitalization duration was not significantly different between the two groups (p>0.05).
Conclusion: Although oral zinc salts inhibit the enterohepatic circulation of bilirubin, however probably not effective in the treatment of neonatal physiologic jaundice. Due to lack of human studies on the effect of oral zinc salts, further studies are recommended.
Hyperbilirubinemia, Phototherapy, Zinc sulfate, Jaundice
http://armaghanj.yums.ac.ir/article-1-1040-en.html
http://armaghanj.yums.ac.ir/article-1-1040-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
Effect of Silver nanoparticles on Passive Avoidance learning in Rats
472
482
FA
parvin
khodarahmi
Islamic Azad University
khodarahmiparvin@yahoo.com
Y
Background & aim: Silver nanoparticles (Ag NPs) have been widely used in many technologies to produce medical devices, food technology and textiles. Silver nanoparticles may be absorbed through the lungs and intestine into circulation and thus may reach such organs as the liver, kidney, spleen, heart and testes and brain. It has been demonstrated that silver nanoparticles may have toxic effects on mammalian cells. There are some alarming reports on the adverse effects of silver nanoparticles on reproduction of experimental animals. Exposure to silver nanoparticles may exert a neurotoxic effect and affect cognitive functions, causing the impairment of short-term and working memory. The purpose of this study was to investigate the possible protective role of Ag NP on the learning and memory of rats.
Methods: The present experimental study was conducted on forty male Wistar rats weighing 200 to 250 g which were divided into five groups of eight as follows: control group and 4 groups of treatment. Control group rats received saline and treatment group’s rats received Ag NP at doses of 50, 250,500 and 1000 mg/ kg/ day using Intra Peritoneal injection (IP) for 14 days. One day after the last injection, the learning and memory function in the rats was examined by the passive avoidance task. Measure of memory and learning were assessed using One-Way ANOVA by SPSS using the Tukey s' test.
Results: The results showed that Ag NP at dose of 50, 250, 500 mg/kg made no significant change in the STL (step-through latency) and TDC (Time in Dark Compartment), compared to the control group in the passive avoidance task. Despite, Ag NP at dose of 1000 mg/kg significantly reduced the STL (p<0.01) and increased TDC (p<0.001), but no significant change in the number of trials (p>0.05) compared to the control group.
Conclusion: These data suggest that ip microinjection of Ag NP could impair learning and memory at high doses.
Silver, Nanoparticles, Learning, Memory, Rats
http://armaghanj.yums.ac.ir/article-1-264-en.html
http://armaghanj.yums.ac.ir/article-1-264-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
The Effect of Eight Weeks of Intense Aerobic Exercise on Chemerin and
483
493
FA
S
Moradi
1Department of Exercise Physiology, Shiraz University, Shiraz, Iran
N
F
Daryanoosh
1Department of Exercise Physiology, Shiraz University, Shiraz, Iran
daryanoosh@shirazu.ac.ir
Y
M
Koushkiejahromi
1Department of Exercise Physiology, Shiraz University, Shiraz, Iran
N
F
Karimi
1Department of Exercise Physiology, Shiraz University, Shiraz, Iran
N
M
Mohamadi
Department of Educational Administration, University of Shiraz, Shiraz, Iran
N
V
Hadidi
1Department of Exercise Physiology, Shiraz University, Shiraz, Iran
N
H
Yousefi
Department of Exercise Physiology, Shiraz University, Shiraz, Iran
N
Background & aim: Adipokines, including omentin and chemerin, are cytokines that are mainly secreted by adipose tissue. The aim of the present study was to investigate the effect of eight weeks of intense aerobic exercise on chemerin and omentin plasma levels in female Sprague Dawely rats.
Methods: In the present experimental study, 35 two-month old Sprague Dawely rats were randomly divided into two groups: control (15 rats) and training (20 rats). The training program included aerobic exercises which were conducted increasingly five times a week for 8 weeks. Blood samples were taken 24 h after the last training session. After eight weeks, an independent t-test and Pearson's correlation coefficient were used for data analysis.
Results: The results showed that there was significant difference between omentin serum levels (p=0.012) and chemerin serum levels (p=0.003) in rats that had undergone exercises with high intensity program as compared to the control group. In addition, no significant correlation was observed between omentin and chemerin levels (p=0.08).
Conclusion: According to the results of the present study as well as the importance of omentin and chemerin level changes, it seems that the training time must be more than 8 weeks and the exercise intensity should be tailored to the individual's fitness level. Otherwise, subjects are not able to perform the exercise program properly.
chemerin, exercises with high intensity, omentin
http://armaghanj.yums.ac.ir/article-1-240-en.html
http://armaghanj.yums.ac.ir/article-1-240-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
Association Study of Polymorphism in CYP3A5 Gene with Bladder Cancer
494
504
FA
m
bakhtiari tajar
Islamic Azad University
bakhtiarim774@gmail.com
Y
Kh
Onsory
Islamic Azad University
onsory@gmail.com
N
p
shadpoor
Tehran university
shadpoor@yahoo.com
N
m
zafarmand
Islamic Azad University
zafarmand@yahoo.com
N
Aims and objectives: The environmental procarcinogen hypothesis of tumour pathogenesis proposes that many carcinogens require metabolic activation by drug metabolizing enzymes to form the proximate carcinogen. CYP3A enzyme catalyzes the conversion of numerous numbers of xenobiotics including carcinogens and drugs and it is involved in metabolic pathways of activation of procarcinogens and/or inactivation of carcinogens during the tumorigenic processes. CYP3A5 is expressed polymorphically in human liver, but consistently in lung, colon, and kidney. An allelic variant of A to G (A6986G) transition causes CYP3A5*3 variant and this polymorphic expression confers low CYP3A5 protein expression as a result of improper mRNA splicing and reduced translation of a functional protein. The purpose of this study was to analysis the frequency of mutations in CYP3A5 gene and to determine the role of its polymorphisms in bladder cancer patients. Methods: For this purpose, PCR-RFLP analysis of the gene was on 113 bladder cancer patients and same number of age-matched controls admitted to Hashemi Nezhad Hospital was performed. Then the data was analyzed using the computer software SPSS for windows (version 19). Results: The incidence of CYP3A5*3 allele was more in patients and control group compared with the wild type (CYP3A5*1). It was 79.6% and 75.2% in patients and controls respectively which indicated that the mutant allele of CYP3A5*3 was more in the studied population with an OR of 1.837 (95% CI=0.975-3.460, P= 0.62). Also there was found that the frequency of both alleles were high in female compared with male. Conclusions: There was no significant association between the risk of bladder cancer for individuals carrying the CYP3A5*3 genotype.
CYP3A5 gene, polymorphism, Bladder cancer, PCR-RFLP.
http://armaghanj.yums.ac.ir/article-1-317-en.html
http://armaghanj.yums.ac.ir/article-1-317-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
Association of IL-18 Gene Polymorphism at Position -137G / C with Vaginal Candidiasis
505
515
FA
M
Solimanipour
1Department of Midwifery and Nursing, Estahban Branch, Islamic Azad University, Estahban, Iran
M_Solimanipour@Iauestahban.ac.ir
Y
S
Naeimi
Department of biology, Kazerun Branch, Islamic Azad University, Kazerun, Iran
naeimis@kau.ac.ir
N
Background & aim: Vulvovaginal Candidiasis (VVC) is a common disease affecting more than 75% of all women at least once in their lifetime. Various factors, including genetic and immunology factors, plays an important role in this disease. IL-18 is an important cytokine in immune system and has several polymorphisms in the promoter region. This study attempted to evaluate associations between IL-18 gene polymorphisms in patients with acute Vulvovaginal Candidiasis.
Methods: In the present case-control study, a total of 100 women with Vulvovaginal Candidiasis and 100 healthy women in Iran were examined. DNA was extracted by saluting out method and Single nucleotide Polymorphisms of the IL-18 gene at positions -607 (C/A) and -137 (G/C) were analyzed by the Allele-specific PCR method and data were compared in both groups by using Pearson’s chi-square test and to investigate that the genotypes study in the position followed the Hardy-Weinberg equilibrium, was assessed by the Arlequin 3.1.
Results: The results of this study showed that the frequency of genotypes of polymorphic position -607 C / A IL-18 genes were not significantly different in patients with vaginal Candidiasis and the control group P> 0.05. On the other hand, in patients ,there was an association with a significant increase in the C allele and CC genotype, of the single nucleotide polymorphisms (SNPs) at position-137G/C in the IL-18 gene promoter and Vulvovaginal Candidiasis ( P< 0.05 ) .
Conclusion: Due to the fact that an increase in the expression of CC genotype and allele C, can lead to reduction of Interleukin-18 gene promoter activity and according to the impact of that activity of this cytokine can lead to Th1 system, it seems that the promoter activity of this gene may lead to reduced activity of the immune system and as a result be prone to vaginal Candidiasis
Vulvovaginal candidiasis, IL-18, Genotype, Polymorphism
http://armaghanj.yums.ac.ir/article-1-281-en.html
http://armaghanj.yums.ac.ir/article-1-281-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
Evaluation the Simultaneous Effects of Progesterone and Vitamin C on Anxiety in Male Wistar Rats
516
525
FA
K
Ferdowsi
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
N
H
Hatami
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
homeirahatami@yahoo.com
Y
G
Dehghan
Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran
N
زمینه و هدف: اضطراب با شیوع متفاوتی در زنان و مردان گزارش شده است. این مسئله بیانگر تأثیر هورمون جنسی بر اضطراب میباشد. از طرفی در بروز اضطراب، استرس اکسیداتیو نیز بیتأثیر نیست. از آنجایی که گزارشهای متناقضی در مورد اثر پروژسترون بر اضطراب وجود دارد، لذا هدف پژوهش حاضر بررسی اثرات اضطراب زایی یا اضطراب زدایی دوزهای مختلف پروژسترون در حضور یا عدم حضور ویتامین ث بود.
روش بررسی: در این مطالعه تجربی از 63 سر رت نر در 9 گروه: سالین، 1 میلیلیتر بر کیلوگرم وزن بدن)حلال ویتامین ث)، شاهد، 1 میلیلیتر بر کیلوگرم وزن بدن (روغن کنجد حلال پروژسترون)، 3 گروه پروژسترون با دوزهای (30 ،10 ،5 میلیگرم/کیلو گرم)، گروه ویتامین ث (80 میلیگرم/کیلو گرم)، 3 گروه پروژسترون با دوز مختلف همراه با ویتامین ث استفاده شد. زمان تزریق 5 روز بود. متغیرهای اضطراب در مدل رفتاری ماز مرتفع به علاوه شکل در روزهای اول و پنجم بررسی شد. دادهها با آزمون آماری آنالیز واریانس یک طرفه تجزیه و تحلیل شد.
یافتهها: پروژسترون در دوز 5 میلیگرم باعث ایجاد اضطراب شد(05/0>p). در حالی که در دو دوز (30 و10 میلیگرم) خاصیت ضد اضطرابی نشان داد(05/0p<). ویتامین ث به تنهایی و همراه با 3 دوز پروژسترون سبب کاهش اضطراب گردید(05/0p<).
نتیجهگیری: به نظر میرسد پروژسترون در دوز پایین اضطراب زا و در دوزهای بالا ضد اضطراب است. ویتامین ث به عنوان یک آنتیاکسیدان سبب بهبود اثرات ضد اضطرابی پروژسترون به ویژه در دوزهای بالا میشود.
Anxiety, Progesterone, Vitamin C
http://armaghanj.yums.ac.ir/article-1-1041-en.html
http://armaghanj.yums.ac.ir/article-1-1041-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
Microbial contamination determination of Cream suit,Traditional Ice Cream and Olovia in Yasuj City
526
537
FA
SS
Khoramrooz
Cellular & Mollecular Research Center, Medical University of Yasuj, Yasuj, Iran
N
M
Sarikhani
Cellular & Mollecular Research Center, Medical University of Yasuj, Yasuj, Iran
N
SA
Khosravani
Cellular & Mollecular Research Center, Medical University of Yasuj, Yasuj, Iran
N
M
Farhang Falah
Cellular & Mollecular Research Center, Medical University of Yasuj, Yasuj, Iran
N
Y
Mahmoudi
Cellular & Mollecular Research Center, Medical University of Yasuj, Yasuj, Iran
N
A
Sharifi
Cellular & Mollecular Research Center, Medical University of Yasuj, Yasuj, Iran
asgharsharifi@yahoo.com
Y
Background & aim: Prevalence of diseases caused by consumption of contaminated food has always been a problem all over the world, and every year spent on improving the disease is costly.Cream suit, Ice cream & olowye for ingredient substance and manufacture & preservation conditional have very high possibility for contamination.The aim of this study is Microbial contamination determination of Cream suit, Traditional Ice Cream and Olovia in Yasuj City
Methods: This study is randomized cross sectional study was performed on 64 samples.The samples were taken from the ice cream and confectionery shops in Yasuj city and keep on cold box then the samples were transported in sterile conditions, to the department of medical microbiology laboratory in medical university of yasuj and microbial contamination rate evaluated by national standard method. Collected data analysed with SPSS software for data description,from central dispersion and table frequency and draw chart.
RESULTS: The survey results showed that 40% o traditional ice cream,cream suit were infected by Staph aurous, Escherichia coli and salmonella respectly (6.7,87 and 0),(50,30 and 0).(0,0 and0) present, and no seen any bacteria on olowye.
Conclusion: Due to our research contamination rate traditional ice cream,cream suit and olowye were by Staph aurous, Escherichia coli and salmonella were very high . therefore using different ways to control bacterial growth especaly E.coli the mostly transmited by fecal oral including the use of healthly and safe raw material for promoting health awareness of people involved in the food preparation and production is essential.
Microbial contamination, Cream suit, Traditional Ice Cream and Olovia
http://armaghanj.yums.ac.ir/article-1-1042-en.html
http://armaghanj.yums.ac.ir/article-1-1042-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
20
6
2015
9
1
The effectiveness of enriching relations between spouses to reduce marital conflict between employees in different offices in Yasouj
538
548
FA
M
Aminianfar
Islamic Azad University of Shiraz, Shiraz, Iran
Y
J
Refahi
Islamic Azad University of Shiraz, Shiraz, Iran
N
Z
Ghaderi
Islamic Azad University of Shiraz, Shiraz, Iran
N
E
Afshoon
Research Center for Social Determinants of Health, Yasouj University of Medical Sciences, Yasouj, Iran
esfandafshoon@gmail.com
N
Objective & aim: Today, divorce and marital turmoil is increasing. Understanding the factors leading to chaos and the disintegration of family relationships is important. This study aimed to explore the effect of enriching relations between spouses, the couple's emotional security and marital conflicts.
Methods: In the present interventional-analytical study, ten different offices were randomly selected. Of people who scored high on marital conflict and emotional security, and also those who gained low scores under 40 were divided randomly into two groups. Seven relations enriching group training sessions were held for the spouses. At the end of the training sessions, both groups were evaluated by emotional security questionnaires by Brunner et al. (2008), marital conflict Sanaei and Barati (1996).
Results: Covariance analysis and multivariate analysis of variance, analysis of the results of the marital conflict, mean and standard deviation of pre couples' marital conflict experimental and control groups were (20/15) and 20/145 (64/16) 70/143 respectively. The test score in two groups were (60/12) and 80/64 (17.4) and 70/143 respectively. The results of multivariate analysis of covariance components of marital conflict on test scores of experimental and control groups and the control effect of pre-test showed that Pylayy effect, Wilks Lambda test, Hotelling effect on the root of F=4.47 and degrees of freedom 7 levels significantly in p=0.0001 Effect of married couples was significant in reducing aggression.
Conclusion: Enrichment relations education for spouses may significantly reduce parameters of marital conflicts.
Effectiveness, Enriching, Emotional Security, Marital Conflicts, Relations between Spouses
http://armaghanj.yums.ac.ir/article-1-983-en.html
http://armaghanj.yums.ac.ir/article-1-983-en.pdf