Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
Effect of Seed Extract (AGSE) (Anethum graveolens L. Seed extract) on Oxidative Stress and Kidney Structure in Hypercholesterolemic Rats
686
701
FA
R
Saeedi
Department of Biology, Urmia University, Urmia, Iran
ronaksaeedy1@gmail.com
N
F
Farokhi
Department of Biology, Urmia University, Urmia, Iran
f.farokhi@urmia.ac.ir
Y
Abstract
Background and Aim: Herbal remedies are used to treat hypercholesterolemia. In this study, the effect of AGSE on renal building changes and oxidative stress in hypercholesterolemic female rats was investigated.
Methods: In this experimental study, 30 female rats were randomly divided in 5 groups of 6 subjects. The control group was healthy with normal diet, the healthy group was treated with 500 mg / kg AGSE, two groups of mice after induction of hypercholesterolemia, 300 mg / kg and 500 mg / kg of AGSE were gavaged for 30 days. The fifth group was treated with normal water and diet after induction of hypercholesterolemia. At the end of the experiment period, weighed the rats and after weaning and blood collection, the left kidneys were weighed then placed into formalin 10%, and 5 micrometers were cut and stained with H & E histological studies. Oxidative stress parameters were measured in the right kidney and the biochemical parameters were measured in plasma. The collected data were analyzed using one-way ANOVA (ANOVA) and Tukey's test.
Results: In hypercholesterolemic mice, the levels of cholesterol, triglyceride, malondialdehyde, blood urea nitrogen, creatinine and weight of mice increased significantly. However, the catalase and renal glomeruli were significantly decreased. While in AGSE-treated rats, these parameters were significantly improved.
Conclusion: The Seed Extract (AGSE) of Anethum graveolens L. with 500 mg / kg, in addition to preserving the structure of the kidney, can have a positive effect on the reduction of blood lipids and lipid peroxidation damage in the kidney in hypercholesterolemia conditions.
Oxidative Stress, Seed, Hypercholesterolemia, Kidney
http://armaghanj.yums.ac.ir/article-1-1906-en.html
http://armaghanj.yums.ac.ir/article-1-1906-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
The Effects of Combined Exercise Training with Aerobic Dominant and Coenzyme Q10 Supplementation on Serum Levels of IL-10 and TNF-α in Patient with Multiple Sclerosis
702
713
FA
J
Nakhzari Khodakheir
Department of Neuromuscular Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran,
elia_3812@yahoo.com
Y
AH
Haghighi
Department of Neuromuscular Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran,
ah.haghighi292@yahoo.com
N
MR
Hamedinia
Department of Neuromuscular Exercise Physiology, Hakim Sabzevari University, Sabzevar, Iran,
mrhamedi1350@gmail.com
N
K
Nikkhah
Department of Neurology, Mashhad University of Medical Sciences, Mashhad, Iran.
amir146nikkhah@gmail.com
N
Abstract
Background and Aim: Multiple sclerosis (MS) is an autoimmune, inflammatory, chronic and progressive disease of central nervous system in which myelin sheath and axons of nerve cells in the brain and spinal cord destroyed by immune system. The change in concentration of cytokines is the major physiological symptom of the disease; whereas physical activity and exercise is an important non-pharmacological method in maintain homeostasis of physiological symptom in MS disease. The aim of this study was to determine the effect of eight weeks of exercise training combined with Q10 supplementation on serum TNF-α and IL-10 in patients with multiple sclerosis.
Methods: In the present experimental research, twenty eight MS patients (EDSS=3-5) were selected by using available sampling method and randomly divided into three experimental groups (combined exercise training + Q10 supplementation, combined exercise training + placebo & Q10 supplementation) and one control group (5 female and 2 male in each group). Two groups of three experimental groups performed a combined exercise program include two sessions of endurance training (%50-60 max HR at beginning to end) and one session of resistance training (%50-60 1RM at beginning to end) three sessions per week. 200 mg of CoQ10 supplement was prescription per day. Blood samples (after 10 hours fasting) were collected 24 hours before the first and 24 hours after the last session of exercise for evaluation of serum levels of IL-10 and TNF-α. Data were analyzed with Shapiro - Wilk and analysis of covariance at a significance level of P<0.05.
Results: The results of covariance analysis showed that there was no significant difference between the serum levels of IL-10 and TNF-α in all three experimental groups compared to the control group. Also, the results of t-test showed that there was no significant difference between the data of serum levels of IL-10 and TNF-α in the post-test compared to the pre-test (P≥0/05).
Conclusion: Combined exercise training with coenzyme Q10 supplementation cannot lead to changes in concentration of IL-10 and TNF-α in patient with MS. Therefore, it is necessary to change the duration and severity of this type of training as well as dose of supplementation.
Multiple sclerosis,
Combined exercise training, Coenzyme Q10, IL-10, TNF-α
http://armaghanj.yums.ac.ir/article-1-1728-en.html
http://armaghanj.yums.ac.ir/article-1-1728-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
The effect of Evening Primrose Oil on Changes in Polycystic Ovary Syndrome Induced by Estradiol Valerate in Rat
714
724
FA
F
Zand Vakili
Department of Obstetrics and Gynecology, Sanandaj University of Medical, Sanandaj, Iran,
farnaz.zandvakili66@gmail.com
N
SH
Zare
Department of Obstetrics and Gynecology, Sanandaj University of Medical, Sanandaj, Iran,
shamsi.zare66@gmail.com
Y
K
Rahimi
Department of Physiology, Shiraz University, Shiraz, Iran
kaveh_rahimi66a@yahoo.com
N
M
Riahi
Department of Physiology, Shiraz University, Shiraz, Iran
moslem.riahi@yahoo.com
N
Abstract
Background and Aim: Polycystic ovary syndrome (PCOS) is one of the most important reproductive and endocrine disorders in women. Evening primrose oil is a phytosterogenic plants, and there are many reports about the effects of phytoestrogens on the hypothalamus-pituitary axis. Regarding the side effects of existing drugs, the aim of this study was to evaluate the effect of evening primrose oil (EPO) on changes in sex hormones, serum glucose and insulin levels and insulin sensitivity in PCOS.
Methods: In this experimental study 30 female Sprague Dawley rats with regular sexual cycle were divided into five groups (n=6). Group 1: control. Group 2: (control treatment) received evening primrose oil gavage at dose of 1000mg/kg for 21 days. Group 3: PCOS induced by estradiol valerate. Group 4: After induction of PCOS received evening primrose oil gavage at dose of 1000mg/kg for 21 days. Group 5: After induction of PCOS received evening primrose oil gavage at dose of 2000mg/kg for 21 days. Finally, blood samples were collected from heart and then sex hormones, glucose and insulin concentrations were determined. The results were analyzed by SPSS software using one-way ANOVA and Duncan 's test.
Results: The FSH level increased significantly in the fourth and fifth groups compared to the third (p <0.05). Levels of LH and testosterone levels were significantly lower in the fourth and fifth groups than the third group (p <0.05). There was no significant difference in the level of FSH and LH among the other groups. The serum levels of insulin and glucose in the fourth and fifth groups were significantly lower than the third group (p <0.05). Also, insulin sensitivity was higher in the treatment groups than in the third group (p <0.05). There was no significant difference in insulin, glucose and insulin sensitivity among other groups.
Conclusions: By changing the concentration of FSH, LH and testosterone hormones in polycystic ovary syndrome, evening primrose oil, can reduce the complications of these hormonal changes. EPO also reduces insulin and serum glucose and increases insulin sensitivity in PCOS. With more complete studies, Evening primrose oil can be recommended as a good alternative to chemical drugs for the treatment of PCOS.
Polycystic ovary syndrome, Evening primrose oil, Sex hormones, Glucose, Insulin
http://armaghanj.yums.ac.ir/article-1-1827-en.html
http://armaghanj.yums.ac.ir/article-1-1827-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
Relationship Between MicroRNA129-2 Expression and Cervical Cancer in Patients Infected with HPV
725
738
FA
ZH
Nazeri Givi
Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran,
zhita.nazeri@gmail,com
N
Kh
Onsory
Department of Biology, Parand Branch, Islamic Azad University, Parand, Iran,
onsory@gmail.com
Y
E
Moslemi
Department of Biology, East Tehran Branch, Islamic Azad University, Tehran, Iran
elham-moslemi60@yahoo.com
N
Abstract
Background and Aim: Cervical cancer is the fourth most common cancer that is the first cause of mortality among women in the world and the seventh rank among all cancers. One of the risk factors for cervical cancer is infection with the papilloma virus. On the other hand, microRNAs have been suggested as new markers for cervical cancer diagnosis. Meanwhile, microRNA129-2 is a cellular proliferation inhibitor and an invertebrate cellular agent. The aim of this study was to evaluate the expression of microRNA129-2 in women with papilloma virus infected cervical cancer and compare it with women with cervical cancer without infection with papilloma virus and healthy group.
Methods: In this semi-experimental study, 20 paraffin tissue samples from women with papilloma virus infected cervical cancer, 20 samples of paraffin tissue from women with cervical cancer without infection of the papilloma virus and 20 samples of normal pap smear from Mirzakochek Khan Hospital The forest was collected in Tehran in 1394. After de-paraffinization, extraction of RNA was performed and expression of miR129-2 was investigated using Real Time PCR method among the groups. Data was analyzed using Grafpad prism6 software.
Results: According to the results a significant decrease was seen in the expression of this gene in infected patients compared to control group (p = 0.0004). Also, expression of miR129-2 in infected tissues of papilloma viruses was reduced in comparison with non-contaminated cancerous tissues (p = 0.0001). Although this decrease in expression was observed between the patients without infection with the papilloma virus and the control group, it was not statistically significant (p = 0.083). There was no significant relationship between expression of miR129-2 with age (p = 0.99) and grade of disease (p = 0.39).
Conclusion: Considering the reduced expression of miR129-2 in cancerous samples, the expression of miR129-2 expression can be considered as a valuable initial diagnostic agent and it plays an important role in determining the prognosis of cervical cancer.
Cervical cancer, Human papilloma virus, miR129-2 expression
http://armaghanj.yums.ac.ir/article-1-1698-en.html
http://armaghanj.yums.ac.ir/article-1-1698-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
Evaluation of Planimetric and Biomechanical Effects of Local Cineol on Healing of Open Wounds, Total Thickness of Skin in Rats
739
753
FA
R
Mohammadi
Department of Surgery and Diagnostic Imaging, Urmia University, Urmia, Iran,
r.mohammadi@urmia.ac.ir
Y
Gh
Jalilzadeh
Department of Internal Medicine and Clinical Pathology, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran
g.jalilzadeh@urmia.ac.ir
N
M
Akbari
Department of Veterinary Medicine, Urmia University, Urmia, Iran
melikaakbaridvm@gmail.com
N
Abstract
Background and Aim: Wound healing is a complicated and promising cellular and biochemical reaction that leads to the recovery of tissue integrity and its tensile strength. The purpose of this study was to evaluate the cinol restorative activity in the rat wound skin wound model.
Methods: In this experimental study, 40 rats were used to evaluate the healing process based on planimetric and biomechanical studies in a period of 21-day after surgery. To evaluate the planet, 20 healthy rats were randomly assigned into 5 groups of 4, including control group (open wound only), control group (open wound with base ointment), one treatment group with 0.25, a treatment group of two with 5 0 and the treatment group was divided into 1% cineol ointment. The percentage of wound healing in all groups was measured on days 3, 6, 9, 12, 15, 18 and 21, by taking a picture with a digital camera and calculating planar measurements. In order to study the biomechanics, 20 rats were randomly divided into 5 groups of 4 in the same manner. On the 9th day, the samples were evaluated for biomechanical evaluation with delivery points, maximum tensile strength, maximum absorbed energy and stiffness. Regarding the contraction of the wounds, the values obtained using repeated measure ANOVA and in the biomechanical study of the obtained results were evaluated in one way ANOVA.
Results: In the treatment group, the biomechanical meta-metrics of the delivery point (1.49 ± 0.51), the maximum tensile strength (1.64 ± 1.03), the maximum absorbed energy (1.74 ± 0.32) and the stiffness of the tissue (1.74 ± 1.11) had a significant difference with control group, treatment group 1 and treatment 3 (p = 0.002). After examining the results of application of different ointments containing 81 cineoles on the skin of the skin wounds, it was observed that using 0.5% ointment in the treatment group 2 on day 15 (5.67 ± 1.10), 18 (40.3% (2.7 ± 0.2) and 21.30 (0.31 ± 0.38) resulted in an increase in the amount of wound squaring and reduction of wound area in comparison with other groups. So that the 0.5% ointment in the treatment group 2 (0.31 ± 0.38) had a faster and more shrinkage than other groups (p = 0.002).
Conclusion: A half-percent cineole ointment on open wounds can be helpful because of increasing the wound's incidence and reducing the time required to fill the wound by young tissues
Wound healing, Cineol, Biomechanics, Planimetric
http://armaghanj.yums.ac.ir/article-1-1814-en.html
http://armaghanj.yums.ac.ir/article-1-1814-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
Effect of Cardiac Rehabilitation with Severe Periodic Exercise Activity on Serum Glycine3 and Mutagenic Fraction in Patients with Heart Failure
754
765
FA
M
Siuf Jahromi
Department of Physical Education, Science and Research Branch, Islamic Azad University, Tehran, Iran,
maryamsiuf@yahoo.com
N
KH
Ebrahim
Department of Physical Education, Shahid Beheshti University of Medical Sciences, Tehran, Iran, 3
K-ebrahim@sbu.ac.ir
Y
MA
Babaeibeigi
Cardiovascular Research Center, Shiraz University of Medical Sciences
m.babaee.med@gmail.com
N
H
Nikbakht
Department of Physical Education, Science and Research Branch, Islamic Azad University, Tehran, Iran,
hojnik1937@yahoo.com
N
Abstract
Background and Aim: Cardiac rehabilitation improves the functional capacity of patients with heart failure. Therefore, the aim of this study was to investigate the effect of eight weeks of high frequency periodic training on mutagenic fraction and serigalctin 3 levels in cardiac patients.
Methods: In this quasi-experimental study, 24 heart patients (57.18 ± 6.17 years, 76.5 ± 13.89 kg, 25.34 ± 3.39 mm, 5.5 ± 5.5 cm) (169 cm) in Alzahra hospital in an injection fraction of 40-50% were randomly divided into two groups of severe routine exercises and control group. The exercise program included 12 repetitions of 1.5 minutes of activity on a bicycle and 8 repetitions of 1.5 times the activity on the treadmill, and between each period, 45 to 60 seconds of active rest with a 40-60% VO2peak intensity, which lasted for 8 Weekly and 3 sessions per week. The intensity of exercise with 50-60% of VO2peak started in the first week and was gradually increased by 10% every week and lasted from the week 4 to the end of the training protocol at an intensity of 80-90%. Blood samples were taken before and 48 hours after the last training session in the same conditions in both groups. Serigalcine 3 levels were measured using ELISA kit. The collected data were analyzed using independent t-test and paired T-test.
Results: The results showed that in the post-intensive training group, the level of Galactine 3 decreased (p = 0.003) and the mutation fraction increased (p = 0.001) in the training group, before the training, and in the control group Compared to pre and post test, Galactin Level 3 was found to increase (p = 0.001) and decrease in mutation fraction (p = 0.003). Comparing the two groups, the training group showed a significant decrease in Galactin 3 (p = 0.001) and a significant increase in the mutation fraction (p = 0.001).
Conclusion: Severe periodic exercises to reduce galactin levels 3 and increase the injectable fraction can improve cardiac function in cardiovascular patients.
Severe Periodic Exercise, Heart Failure Patients, Galactin-3, Injection Fraction
http://armaghanj.yums.ac.ir/article-1-1915-en.html
http://armaghanj.yums.ac.ir/article-1-1915-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
Cognitive impairment in children with hemophilia and children with acute Lymphoblastic leukemia (ALL): Comparison of children with hemophilia and leukemia with healthy children
766
780
FA
M
Firoozi
Department of Psychology, University of Tehran, Tehran, Iran
mfiroozy@ut.ac.ir
Y
Z
Azadfar
Department of Psychology, University of Tehran, Tehran, Iran
shadi_dalouchi1990@yahoo.com
N
Abstract
Background and Aim: Childhood cancer is associated with fatal disorder and Countless studies about the psychological damage to children with cancer, increasing prejudice toward this group of children. The aim of this study was evaluate the accuracy of prejudices via comparison of children with cancer and children with hemophilia in cognitive impairments.
Methods: In this study, as a causal-comparative investigation, participated 50 children with hemophilia, 50 children with acute leukemia and 50 healthy children, in range of 7-12-year-old who referred to a children hospital (Mofid Hospital). In this study, a computerized version of N-back working memory test for assessing working memory function, Continuous Performance Test (CPT) for Attention Maintenance, and Wisconsin Card Sorting Test (WCST) for Executive Function and flexibility were applied.
Results: In N-back test, both groups of children with hemophilia and ALL in compare to healthy children reveal faint function in correct answer and no answer (P<0.001), but there is no significant difference between two groups of children with healthy ones in reaction time. In attention maintenance, children with hemophilia react weakly to variables like error in providing response, error elimination and the number of correct answers (P<0/001) but there were no significantly difference between two groups of children in reaction time. Comparing children with ALL and children with hemophilia in executive function showed children with hemophilia couldn’t react well in variables % correct, % Errors, Categories achieved, and Failures to maintain set. Children with hemophilia did not differ from children with acute Lymphoblastic leukemia (e.g. active memory) in some of indicators their functions were worst (such as executive functions) and both groups showed poorer performance than healthy children.
Conclusion: Leukemia is thought to be worse off than its hemophilia in consequences and cognitive impairment, while this study has shown that other chronic diseases, such as hemophilia, can cause the same cognitive impairment as well. The results of this study emphasize that cognitive interventions are necessary for children with chronic diseases related to blood disorders.
Working memory, Executive functions, Attention-maintenance, Hemophilia, Acute Lymphoblastic leukemia (ALL).
Working memory, Executive functions, Attention-maintenance, Hemophilia, Acute Lymphoblastic leukemia (ALL).
http://armaghanj.yums.ac.ir/article-1-1674-en.html
http://armaghanj.yums.ac.ir/article-1-1674-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
Effect of Frequency Aerobic Exercise on Expression of Bcl-2 and Bax Gene in Mice With Myocardial Infarction
781
791
FA
M
Ghahremani
Department of Physiology, Islamic Azad University, Tehran, Iran,
mehran.physiology@gmail.com
N
MA
Azarbaijani
Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran
mehrangilan@gmail.com
Y
M
Piri
Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran
mehrangilan@gmail.com
N
A
Raoufi
Department of Physiology, Tehran University of Medical Sciences, Tehran, Iran
mehran.physiology@gmail.com
N
Abstract
Background and Aim: Myocardial infarction (MI) is a permanent and irreversible cell death and death of the myocardium. Physical training reduces cardiac muscle apoptosis, but its molecular process is still unknown in response to activity and also the intensity of exercise. Exercise activity can be expected to prevent cell death by influencing the most important factors affecting the apoptosis process. Therefore, the aim of this study was to investigate the effect of aerobic exercise intensity on apoptosis in rats with myocardial infarction.
Methods: In this experimental study, 18 male Wistar rats with myocardial infarction were divided into three groups: High intensity periodic exercise (HIIT), Low intensity (LIIT) and Control group (without exercise). Bcl-2 and Bax cardiomyocyte concentrations were evaluated as the main markers of apoptosis by qRT-PCR method.
Results: Bcl-2 values were significantly higher in the high intensity exercise group (HIIT) than in the control group (p = 0.077), in the low intensity periodic exercise group (LIIT) (p = 0.017) were more than the control group. Bax values were significantly higher in the high intensity periodic exercise group (HIIT) (p = 0.019) than in the control group. While in the low intensity exercise group (LIIT), there was no significant increase compared to the control group (p = 0.98). BCL-2 values in the low intensity periodic exercise group (LIIT) were higher than the high intensity periodic exercise group (HIIT) (p = 0.023). Bax index values in the high intensity periodic exercise group (HIIT) were higher than the low intensity exercise group (1.91).
Conclusion: Periodic training was performed by expression of Bcl-2 and Bax gene and as a result of reduction of apoptosis in cardiomyocytes after myocardial infarction, which depends on the intensity of exercise. In addition, low intensity periodic exercises have a greater effect than high intensity periodic exercises. On this basis, it is recommended that attention be paid to intensive training in cardiac rehab.
Apoptosis, Myocardial infarction, Very intense exercise,Bcl-2 , Bax
http://armaghanj.yums.ac.ir/article-1-1888-en.html
http://armaghanj.yums.ac.ir/article-1-1888-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
The Effectiveness of Cognitive-Behavioral Group Therapy on Coping and Self-Control Styles in Multiple Sclerosis Patients
792
803
FA
E
Sadri Damirchi
Department of Educational Sciences, University of Mohaghegh Ardabili, Ardebil, Iran,
araz_sadri@yahoo.com
Y
M
Aghazadehasl
Department of Clinical Psychology, Urmia University, Urmia Islamic Azad University, Urmia, Iran
araz.sadri@gmail.com
N
Background and Aim: Multiple sclerosis is one of the most common chronic diseases of the central nervous system. In recent years there have been a growing number of diseases. The purpose of this study was to evaluate the effectiveness of cognitive and behavioral group therapy on coping styles and self-control in patients with multiple sclerosis in Urmia
Methods: This was a quasi-experimental design with pretest-posttest design with control group. The statistical population of this study was all patients with MS. In Urmia, in the year of 1395. There were 30 patients in the experimental group and one in control group (15 in each group). Using randomized simple sampling and drafted random sampling They were selected by referring to the MS Society. Before the implementation of the educational programs, the two groups were tested by the Andler & Parker Coping Style Questionnaire and Tangie's self-control styles, then they were trained for the experimental group of cognitive-behavioral therapy and the control group did not receive any training. After conducting educational programs, both groups were tested by questionnaires. Covariance analysis was used to analyze the data
Results: The results of this study showed that cognitive-therapist treatment has an effect on coping styles and self-control in MS patients. In the other words, cognitive-behavioral therapy increased the problem-oriented coping style (p <0.004) and decreased emotional-focused coping style (p <0.004), avoidant coping style (p <0.005) ) and self-control (p <0.002) in patients.
Conclusion: The results emphasize the importance of these interventions in MS patients and the presentation of new horizons in interventions.
Coping strategies, Self-control, Cognitive-behavioral therapy, Multiple sclerosis
http://armaghanj.yums.ac.ir/article-1-1349-en.html
http://armaghanj.yums.ac.ir/article-1-1349-en.pdf
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
22
6
2018
2
1
A Case Report: Acute Kidney Injury and Cardiac Arrest After Poisoning with the Uncommon Type of Rodenticide (zinc Phosphide) in Yasouj
804
811
FA
S
Hasanzadeh
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
Sajad.hassanzadeh@gmail.com
N
M
Sedaghat talab
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
moslem.sedaghattalab@gmail.com
N
M
Tahmasebi
Department of Emergency Medicine, Yasuj University of Medical Sciences, Yasuj, Iran,
m.tahmasebi80@yahoo.com
N
A
Arya
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
arya91842@yahoo.com
N
M
Rohani
Department of Obstetric and Gynecology, Yasuj University of Medical Sciences, Yasuj, Iran
m_rohani247@yahoo.com
N
E
Masnavi
Department of Obstetric and Gynecology, Yasuj University of Medical Sciences, Yasuj, Iran
Elahe.masnavi@yahoo.com
N
S
Jokar
Department of Internal Medicine, Yasuj University of Medical Sciences, Yasuj, Iran
jokar4132@gmail.com
Y
Abstract:
Background and Aim: Zinc phosphate is a solid gray chemical compound whose commercial sample is dark or even black and white. Severe hypertension and cardiac poisoning are the most serious complications of zinc phosphate poisoning and are associated with a high mortality rate. Poisoning with zinc phosphide as a rat poison, which has similar effects to aluminum phosphide tabletsis is uncommon. The report relates to a death case following poisoning with zinc phosphide mice.
Case Report: The patient was a young 18-year-old man who was admitted to suicide attempted at hospital. Due to the lack of toxic poison, the patient was treated with supravavalin as probable toxicity. After several hours of admission, his level of consciousness was reduced with deep breathing. In the tests after the onset of shortness of breath, pH was 6.94, HCO3: 4.9, blood sugar 21, creatinine 6.1 and BUN: 24. Then, the zinc phosphate was detected. Despite the onset of treatment, after 1 hour, the patient suffered from cardiopulmonary arrest and eventually died.
Conclusion: Poisoning with zinc phosphide can cause acute renal failure. Considering that phosphide is one of the poisonous toxins of rodents, especially in rat poison, toxic poisoning with phosphodies is also recommended in poisonous toxin poisoning cases.
Poisoning, zinc phosphide, Rodenticide. Acute Kidney Injury
http://armaghanj.yums.ac.ir/article-1-1883-en.html
http://armaghanj.yums.ac.ir/article-1-1883-en.pdf