@article{ author = {Naseripour, M and Nikeghbali, A and Vadipour, A and Bakhtiari, P and Ahadian, A}, title = {Combined Transpupillary Thermotherapy with Subtenon Triamcinolone Injection in Treatment of Choroidal Neovascularization Secondary to Exudative Age Related Macular Degeneration}, abstract ={ABSTRACT: Introduction & Objective: In spite of several treatment methods which are being used to treat exudative age-related macular degeneration (ARMD) like laser therapy, Intravitreal steroids injections or anti-vascular endothelial growth factors (VEGF), no method has been yet presented as the best treatment way. This study aimed to assess the effectiveness of combined transpupillary thermotherapy (TTT) with subtenon triamcinolone acetonide (TA) injection in treatment of choroidal neovascularization (CNV) in patients with ARMD. Materials & Methods: In this clinical trial, 63 eyes of 57 patients with CNV secondary to exudative age-related macular degeneration (ARMD) were studied. All CNVs (including 20 predominantly classic and 43 predominantly occult lesions) were treated with diode laser (810nm). In 20 eyes with predominantly classic CNVs, 20 mg and 40 mg subtenon triamcinolone was injected in 12 and 8 eyes respectively. The patients were followed for a mean of 9.1 months (ranging from 5.5 to 16 months). The average number of treatment sessions was 1.25. In 43 eyes with occult CNV, 20 mg and 40 mg subtenon triamcinolone was injected in 31 eyes and in 12 eyes respectively. Mean follow up time was 12 months (4.5 to 23 months). Mean treatment times was 1.17. A variable spot size of 0.8, 1.2, 2 and 3 mm was used depending on the size of CNV and treatment was given in one area for 1 minute. Thermotherapy was adminstered through a contact lens at a power range between 120-560 mw. At the end of treatment, each patient randomly received 20 mg or 40 mg subtenon triamcinolone acetonide injection in superotemporal quadrant. Outcome was assessed with clinical and angiographic examination.collected data were analyzed by one-sample and paired –sample T test, using SPSS software. Results: At the end of the study in first group, visual acuity remained stable (0 to ± one line) in 14 out of 20 (70 %) of eyes, improved (> one line) in 2 of 20 (10 %) eyes and showed a decline (> one line worsening) in 4/20 (20 %) eyes. In second group thirty one eyes (72.1 %) had stable vision (± 1 line), 4 eyes (9.32 %) had better vision more than 1 line and 8 eyes (18.6 %) had more than 1 line decrease in vision. Conclusion: All CNVs were closed in last follow up. No statistically significant difference was found between two groups in clinical and functional with 20 mg and 40 mg injection of subtenon TA. Combined TTT and subtenon injection of TA in eyes with exudative ARMD can be an effective method to stabilize visual acuity of these patients.}, Keywords = {KEYWORDS:Age Related Macular Degeneration, Choroidal Neo-Vascularization, Transpupillary Thermo-Therapy,Subtenon Triamcinolone Aacetonide}, volume = {13}, Number = {1}, pages = {1-13}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-624-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-624-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Akbari, A and Hosseinifar, M and خیرآبادی, N and JahanshahiJavaran, P}, title = {Comparison of the Effect of Exercise Therapy with Transcutaneous Electrical Nerve Stimulation on Improvement of Pain and Function in Patients with Patellofemoral Pain Syndrome}, abstract ={ABSTRACT: Introduction & Objective: One of the most common disorders of the knee joint in adult is patellofemoral pain syndrome. Sometimes it becomes chronic and causes activity limitation. This study aimed to compare the efficacy of exercise therapy with Transcutaneous Electrical Nerve Stimulation on improvement of pain intensity, knee function, muscle atrophy and range of knee flexion. Materials & Methods: This double-blind, randomized clinical trial was carried out in Zahedan Razmejo-Moghadam Physiotherapy Clinic, in 2007. Thirty-two patients with patellofemoral pain syndrome were recruited through simple non-probability sampling. Subjects were randomly assigned to one of the equal groups, exercise therapy (including hip, knee, and leg muscles strengthening and stretching exercises) or electrical stimulation group. Before and after intervention, we assessed pain through Visual Analog Scale (VAS) (ordinal), function (ordinal) with Knee Injury and Osteoarthritis Outcome Score (KOOS), thigh circumference with tape measure (centimeter) and range of knee flexion with goniometer (degree). A 10 session treatment program, three sessions per week and one hour per session was performed for both groups. Independent t-test or Mann-Whitney U and paired t-test or Wilcoxon were used for comparison between the pretreatment and post treatment results between groups and within groups, in SPSS software, respectively. Results: The mean total score of knee function increased from 100.53±19.25 to 130.87±18.25 in the electrical stimulation group and from 107.67±22.69 to 131.47±15.11 in the exercise therapy group (p=0.001). The mean score of knee function subscales including symptoms, pain, functional limitation, recreational activity, and life style improved in both groups (p<0.05). The pain score and range of knee flexion improved in both groups (p<0.05). After treatment, range of knee flexion significantly increased in the exercise group compared with the electrical stimulation one (p=0.008). Conclusion: Both of the exercise therapy and transcutaneous electrical nerve stimulation are effective in treatment of patellofemoral pain syndrome. However, exercise therapy is more effective increasing in the range of knee flexion.}, Keywords = {KEYWORDS:Patellofemoral Pain Syndrome,Exercise Therapy,Electrical Stimulation, Knee Function }, volume = {13}, Number = {1}, pages = {15-27}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-625-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-625-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {JazayeriShooshtari, SM and Hafezi, R and Azizi, S and Amanolahi, A}, title = {Comparison of Effect of EMLA Cream and Injection of Methyl Prednisolone Acetate Relief of Pain Associated with Carpal Tunnel Syndrome}, abstract ={ABSTRACT: Introduction & Objective: A standard treatment option for carpal tunnel syndrome (CTS) is local injection of anesthetic-corticosteroid. This clinical trial was designed to compare the safety and efficacy of daily application of the EMLA cream with that of a single injection of methyl prednisolone acetate. Materials & Methods: This is a clinical trial which was performed in the clinics of Shiraz medical school in 1386. Sixty five participants with clinical and electrodiagnostic evidence of mild to moderate CTS were randomized to receive either the EMLA cream (group 1) or one injection (40 mg) of methylprednisolone acetate at wrist (group 2). Visual analog scale was used to assess the patients’ pain acuity. Collected data were statistically analyzed by SPSS software using Chi-Square test. Results: Pain intensity before and after treatment and also 4 weeks after treatment in group A was 5.8±0.98 , 0.7±0.82 and 2.1± 1.2 and 5.7 ±1, 2.4±1.5 and 1.6±1.4 in group B. The differences in pain intensity in both group were significant (p<0.001). Conclusion: EMLA cream was effective in reducing pain associated with CTS. It can be an effective, noninvasive symptomatic treatment for the patients with mild to moderate CTS.}, Keywords = {KEYWORD:Lidocaine &amp, Perilocaine (EMLA), Methyprednisolone Acetate,Carpal Tunnel Syndrome (CTS)}, volume = {13}, Number = {1}, pages = {27-35}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-627-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-627-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Karahmadi, M and Esmaili, H}, title = {Comparative Efficacy of Iranian and Foreign Methylphenidate in Children with Attention Deficit Hyperactive Disorder}, abstract ={ABSTRACT: Introduction & Objective: Methylphenidate is one of the basic drugs in treating ADHD. According to many clinical studies, the foreign form of methylphenidate (ritalin) is more efficient than the Iranian form of the drug (stimidate). This study aimed to compare the efficacy of stimidate and Ritalin in the treatment of attention deficit hyperactive disorder. Materials & Methods: In this double blind, randomized clinical trial, 200 children with attention deficit hyperactive disorder who referred to Isfahan psychiatric clinics were studied. For 100 of these patients ritalin was prescribed while others received stimidate. After 4 weeks, changes in severity of symptoms were evaluated with parental form of Conner's questionnaire. Results: After 4 weeks of treatment, the mean decrease of Conner's number in Ritalin group was 19.63±13.5 and in Stimidate group was 3.29±7.2. Ritalin had effectiveness in treatment of 83.3 percent of the patients ( 6 reduction in Conner's number), but Stimidate was only effective in treating 37.5 percent of the patients. Conclusion: This study showed that foreign methylphenidate (ritalin) is more effective than the Iranian form of the medicine (stimidate).}, Keywords = {KEYWORDS:Methylphenidate, Attention Deficit Hyperactive Disorder,Effectiveness}, volume = {13}, Number = {1}, pages = {37-44}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-628-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-628-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Nassiri, M and Khaki, A and Bazi, P and Khaki, A and Sahizadeh, R and Sahizadeh, A}, title = {Ultra-Structure Study of Lead Acetate Cytotoxic Effects on Testis in Rabbit}, abstract ={ABSTRACT: Introduction & Objective: Lead is one the world wide using metals it has been used since ancient time. It is also a toxin, known to have adverse effects on the body even at low level of exposure and it induces a bread range of physiological, biochemical, and behavioral dysfunctions. Studies have been showed that this metal has harmful effects on several tissues such as: nervous system, blood tissues, and cardiovascular system, reproductive and urinary system. Because it damage human, animal and plants. Nowadays has been attended on this metal. Materials & Methods: White male rabbits of New Zealand race were used and divided into two groups. Experimental groups (N =10) 6.5 Mg/Kg of lead acetate were injected intraperitoneally every other day to each animal for 7 weeks as chronic dose and control group (N=10) were injected only with demonized water. After taking biopsy from testis tissues of each group, tissue preparation was performed for LM and EM studies as standard method. Morphologic study was carried out on electron micrographs. Data have been compared using statistically methods. Results: Morphological findings showed that testis tissue in experimental group that chronic dose has been sever changed histologically compared with control group. Seminifar tubules diameter showed significant decrease (p<0.05). Primary spermotocyte nucleus showed heterochromatin and mitochondria showed vacuelaution Conclusion: These results (based on present study findings) revealed that lead acetate could have vivid effects on testis tissue during chronic dose.}, Keywords = {KEYWORDS: Lead Acetate,Testis Tissue, Cytotoxic,Rabbit}, volume = {13}, Number = {1}, pages = {45-53}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-630-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-630-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Rafati, A and Dasht, MH}, title = {Role of Estrogen on Prevention of Morphine Addiction in Ovarectomized Female Rats}, abstract ={ABSTRACT: Introduction & Objective: Evidence indicates that the biological response and the causes of drug abuse may be different between women and men. These sex differences in drug abuse may be due to socio-cultural factors or biological (hormonal) differences. Estrogen is one of the hormones which involves in dopamine release in striatum and nucleus accumbency and also is one of the most important neurotransmitters in central nervous system which has critical role in morphine addiction. So, in this study we survey the role of estrogen on dependency and tendency to morphine in rat as a factor of sex differences in addiction. Materials & Methods: This experimental study was carried out in Yazd University of Medical Sciences. Behavioral changes like morphine craving was evaluated by self-administration as a criterion for tendency and for assessment of dependency. we evaluated withdrawal syndrome sings (e.g. jumping, wet dog shaking, etc) in control group (ovarectomized female rats receiving morphine sulfate solution) and test group (ovarectomized female rats, pretreated with estradiol benzoate before receiving daily morphine sulfate solution). Data obtained were analyzed by SPSS software, using T-test analysis Results: Results showed that although pretreatment with estradiol in test group might lead to a significant decline in withdrawal syndrome sings in comparison with control group, differences in morphine craving as a criterion for tendency was not significant between the two groups. Conclusion: According to our findings, it seems that estrogen, through central mechanisms and its effect on brain dopaminergic system, reduces the physical dependency to morphine.}, Keywords = {KEYWORDS:Prevention, Addiction, Morphine, Estrogen}, volume = {13}, Number = {1}, pages = {55-63}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-634-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-634-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Zomorodian, K and Tarazooie, B and Saadat, F and Khodadadi, H}, title = {The Effects of Antifungal Azoles on Inflammatory Cytokine Production in Human Keratinocytes}, abstract ={ABSTRACT: Introduction & Objective: Azoles drugs are being used successfully in treatment of fungal infections. Recently, immunosuppressive effects of some of these agents have been reported. Keratinocytes, as the major cells of the skin, have an important role in innate immunity against pathogenic agents. Considering the scanty of information about the effects of azoles on immune responces, this study was conducted to assess the expression and secretion of inflammatory cytokines in keratinocytes following treatment with azole drugs. Materials & Methods: This is an exprimental study conducted in in molecular biology division in Tehran University of Medical Sciences and Immunodermatology Department in Vienna Medical University. Primery keratinocytes were cultured and treated with different concentrations of fluconazole, itraconazole, ketoconazole and griseofulvin. Secreted IL1, IL6 and TNF-α by keratinocytes in culture supernatant were measured by quantitative enzyme immunoassay technique. Moreover, expression of the genes encoding IL1 and IL8 was evaluated by Real Time-PCR. Results: Treatment of keratinocytes with different concentrations of fluconazole and low concentration of ketoconazole resulted in decrease in IL1 secretion, but Itraconazole and griseofulvin did not show such an effect at the same concentrations. In addition, none of the examined drugs had an effect on secretion level of IL6 and TNF-α. Quantitative analysis of IL1 and IL8 encoding genes revealed that transcription on these genes might be suppressed following treatment with fluconazole or ketoconazole. Conclusion: Fluconazole and ketoconazole might modulate the expression and secretion of IL1 and IL8 and affect the direction of immune responses induced by keratinocytes}, Keywords = {KEYWORDS:Inflammatory cytokines, Ketoconazole, }, volume = {13}, Number = {1}, pages = {65-75}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-635-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-635-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Ghahremani, L and Niknami, SH and Mosavi, MT and Heidarnia, AR and KarimzadehShirazi, K and Babaei, GH}, title = {Transtheoretical Model-based (TTM) Interventions to Improve Physical Activities in Elderly Men}, abstract ={ABSTRACT: Introduction & Objective: Understanding and influencing the determinants of physical activity is an important public health challenge. This study examines the application of key constructs of the transtheoretical model to physical activity behaviors for aged people. Materials & Methods: This study is a field trial with census sampling. Sixty healthy adult men at Kahrizak nursing home in 1386 completed a questionnaire including demographics and self-reported levels of physical activity, constructed from the Transtheoretical Model (TTM), before and after two months of intervention. The interventional program included tailored counseling and focus group. The data were then analyzed with T test, X2, pair T test and Wilcoxon, using SPSS software. Results: Statistical analysis showed a significant difference for the effect of health education program on increasing stage of change, self-efficacy, decisional balance and physical activity behavior in elderly people (p<0.0001). Conclusion: Educational physical activity interventions can result in increased physical activity, thus, health education program based on TTM has had positive effect on promotion physical activity behavior. It can be recommended that health education be used on educational models.}, Keywords = {KEYWORDS: Transtheoretical, Physical Activity, Older People}, volume = {13}, Number = {1}, pages = {77-88}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-636-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-636-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Seif, F and BaiatianiKheirolah, MR and BaiatianiKheirolah, MJ and Ansari, M and Sohrabi, A and Hosseini, F}, title = {Evaluation of Radiosensitivity of HeLa Cells Infected with Polio Virus Irradiated by Co 60}, abstract ={ABSTRACT: Introduction & Objective: The main purpose of radiotherapy is exposing enough doses of radiation to tumor tissue and protecting the normal tissues around it. Tumor dose for each session in radiotherapy will be considered based on radiosensitivity of the tissues. The presence of viral diseases in tumoral area can affect the radiosensitivity of cells. This study aimed to evaluate the radiosensitivity of Hela cells infected with poliomyelitis virus irradiated by Co 60. Materials & Methods: In this study, the radiosensitivity of HeLa cells, with or without the viral infection, after gamma radiation of cobalt 60, was assessed. Results: Results of comparison of the radisensitivity of infected and uninfected cells indicates that after 2 Gy irradiation by Co 60, polio infection in low, moderate and high virus load, increases the cell death by 20-30%, 30-40% and 70-90% respectively. Conclusion : Radiosensitivity of tumoral cells increase when they are infected with viral agents. Results of this study showed that non cancer diseases should be considered when prescribing dose fraction in radiotherapy of cancers.}, Keywords = {KEYWORDS:Radiosensitivity, HeLa Cells, Polio Virus}, volume = {13}, Number = {1}, pages = {89-95}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-637-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-637-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Dabiri, N and GhafarianShirazi, HR}, title = {Incidence of Acneform Lesions in Previously Chemically Damaged Persons-2004}, abstract ={ABSTRACT: Introduction & Objective: Chemical gas weapons especially nitrogen mustard which was used in Iraq-Iran war against Iranian troops have several harmful effects on skin. Some other chemical agents also can cause acne form lesions on skin. The purpose of this study was to compare the incidence of acneform in previously chemically damaged soldiers and non chemically damaged persons. Materials & Methods: In this descriptive and analytical study, 180 chemically damaged soldiers, who have been referred to dermatology clinic between 2000 – 2004, and forty non-chemically damaged people, were chosen randomly and examined for acneform lesions. SPSS software was used for statistic analysis of the data. Results: The mean age of the experimental group was 37.5 ± 5.2 and that of the control group was 38.7 ± 5.9 years. The mean percentage of chemical damage in cases was 31 percent and the time after the chemical damage was 15.2 ± 1.1 years. Ninety seven cases (53.9 percent) of the subjects and 19 people (47.5 percent) of the control group had some degree of acne. No significant correlation was found in incidence, degree of lesions, site of lesions and age of subjects between two groups. No significant correlation was noted between percentage of chemical damage and incidence and degree of lesions in case group. Conclusion: Incidence of acneform lesions among previously chemically injured peoples was not higher than the normal cases.}, Keywords = {KEYWORDS:Chemical Gas, Acneform Lesion, Chemical Damaged Persons }, volume = {13}, Number = {1}, pages = {97-104}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-638-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-638-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {RayganShirazi, AR and MariOryad, H and Malekzadeh, JM}, title = {Solid Wastes Management of Yasuj Hospitals, Iran 2006}, abstract ={ABSTRACT: Introduction & Objective: Unhygienic methods of colleting, storage, transportation and disposal of the hospital wastes results in serious hazards that can endanger the health and environment. These materials are classified as dangerous, and have to be collected and disposed based on special rules. Materials & Methods: In the present study we aimed to evaluate the quality of management of hospital wastes and to estimate the waste constituents in Yasuj hospitals. Density, constituents, methods of collecting, transportation and disposal of hospital wastes were evaluated in 3 consecutive days of every months of the year 2006. Results: Study showed that the daily production of solid wastes was 5.5 Kg per hospital bed and infected solid wastes were estimated to be 1.5 Kg per hospital bed. The total solid waste production was 1350 Kg per day which included 27.2 percent as infected solid wastes. Solid waste density was 160.7 Kg per cubic meter and its constituents were food wastes (19.753%), rubber (47.02%), paper (12.05%), glass (5.211%), metals (3.41%) and bandages, gases, clothes, etc (12.556%). Conclusion: The findings suggest that the solid waste management of the studied hospitals is not satisfying and more attention must be paid to the critical issues, such as plans for reducing solid wastes, isolating infected solid wastes at the production site and using safe and updated methods of disposal of solid wastes.}, Keywords = {KEYWORDS:Solid wastes, Hospital, Infectious wastes, Wastes Density }, volume = {13}, Number = {1}, pages = {105-113}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-639-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-639-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Pourmahmoudi, A and AkbartabarTuri, M and Poursamad, A and Sadat, AM and Karimi, A}, title = {Determination of Peroxide Value of Edible Oils Used in Restaurants and Sandwich Shops in Yasuj in 2006}, abstract ={ABSTRACT: Introduction & Objective: Nowadays the extensive changes in lifestyle resulted in an increase in consumption of fast food. This type of food, because of using deep–fat frying, may contain some toxic or unfavorable substances which have adverse effects on consumers’ health. The aim of this study was to determine the peroxide value of edible oils which are used in restaurants and sandwich shops in Yasouj city. Materials & Methods: This descriptive study was carried out on all sandwich shops (n=36) and restaurants (n=12) in Yasuj city in 2006. All samples and questionnaire data in restaurants and sandwich shops were collected at 11:30am and 12:30pm respectively based on a national standard protocol, number 493, by a food expert. The peroxide value was determined based on national standard procedure, number 4179, in a food laboratory and the acceptable limit was defined as 7 meq/kg. Results: Findings of this study showed that in terms of health rules and regulations, at least 50% of oils used in restaurants and 70% in sandwich shops were unfavorable. Peroxide value of 58.3% of oils in restaurants and 97.3% in sandwich shops was greater than the acceptable limit. Conclusion: These findings have shown that the health rules and regulations for the oils are not exercised in Yasouj restaurants and sandwich shops and this can have adverse effects on consumers’ health.}, Keywords = {KEYWORDS:Oil, Peroxide Value,Sandwich Shop,Restaurants}, volume = {13}, Number = {1}, pages = {115-123}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-640-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-640-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} } @article{ author = {Seidoshohadaei, F and Ghafari, A}, title = {A Case Report of Ruptured Spontaneous Heterotopic Pregnancy}, abstract ={ABSTRACT: Introduction & Objective: Heterotopic pregnancy refers to the simultaneous occurrence of pregnancy intrauterine and outside of uterine corpus. It is most often manifested in women who have undergone artificial reproductive technology (ART) but rarely occurs spontaneously. Heterotopic pregnancy still remains as a diagnostic and therapeutic challenge to practitioners. In this situation physicians should have high suspicion for diagnosis and intrauterine pregnancy protection. This study reported a case of ruptured spontaneous heterotopic pregnancy. Case: A 32 year-old woman with abdominal pain, nausea, vomiting and hypovolumic shock in 1386 referred to emergency department in Sanandaj hospital. She reported one previous cesarean section. On examination, the patient's abdomen was distended. She had generalized tenderness and rebound tenderness in abdomen. The ultrasonographic examination revealed large amount of fluid in pelvic and abdominal cavity with a large hematoma in right adnex but there was intrauterine pregnancy at 7 weeks with normal fetal heart activity. She underwent laparotomy for heterotopic pregnancy and ruptured tube with tubal pregnancy removed. Intrauterine pregnancy continued without problem and led to birth of a healthy female neonate. Conclusion: Physicians should be quite cautious of heterotopic pregnancy in woman at reproductive age. Any abnormality on physical examination or ultrasonography of a patient with intrauterine pregnancy and abdominal pain should heighten the clinician's suspicion for heterotopic pregnancy}, Keywords = {KEYWORDS:Intrauterine Pregnancy, Heterotopic Pregnancy,Artificial Reproductive Technology (ART}, volume = {13}, Number = {1}, pages = {125-132}, publisher = {Yasuj University Of Medical Sciences}, url = {http://armaghanj.yums.ac.ir/article-1-641-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-641-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2008} }