@article{ author = {Irani, D and Islahi, A and Jamshidi, F and Akbari, A and Salari, M and Panah, A and Zeighami, SH and Ebrahimi, B and Karami, A}, title = {The Effect of Prostatic Regional Block Using Bupivacaine on the Unpleasant Sensation Caused by Urethral Catheter after Prostate Resection through Urethra}, abstract ={Background & aim: Transurethral resection of the prostate (TURP) is) is a routine telescopic surgery for the treatment of benign prostatic hyperplasia, which results in an unpleasant sensation due to the presence of a urinary catheter. Studies have shown that muscarinic receptor antagonists and opioids can reduce the incidence and severity of this unpleasant sensation. Therefore, the aim of the present study was to determine the effect of localized prostate blockade using bupivacaine on the unpleasant sensation caused by a urethral catheter after prostate resection surgery.   Methods: The present study was a double-blind randomized clinical trial research. The statistical population included 42 patients scheduled for TURP in the hospitals of Shiraz University of Medical Sciences. Patients were divided into two groups: one bupivacaine treatment group (0.5mg/kg) by trans-perinatal method in periprostatic space on both sides and two (control group). In this study, the degree of discomfort until recovery was evaluated every half hour, the duration of Aldrete score to 9 and the degree of dissatisfaction caused by urethral catheter in patients undergoing prostate resection. The collected data were analyzed using statistical tests of Kolmogorov-Smirnov test, t-test, Mann-Whitney.   Results: Both study groups were similar in terms of baseline characteristics. Urinary catheter dissatisfaction was assessed after surgery and a significant difference was seen between the two groups. The mean time of patients in the recovery room in group two groups of control was significantly longer than group one (p≤0.165) and these patients reached the Aldrete score of 9 in a longer period of time. The mean duration of patients in the control groups in the recovery room was 118.81±56.45 minutes and in the treatment group were 97.14±27.90 minutes. No statistically significant difference was observed in morphine use between the two groups and no specific complication was observed in either groups.   Conclusion: Consuming bupivacaine for localized blockade of the prostate in patients undergoing prostate resection surgery can reduce the discomfort caused by the presence of a urinary catheter, the length of time in the recovery ward and the level of dissatisfaction in recovery ward patients.   Keywords: Transurethral Resection of the Prostate, TURP, Benign Prostatic Hyperplasia, Bupivacaine, Pain, Recovery, Localized Blockade  }, Keywords = {Transurethral resection of the prostate, TURP, Benign prostatic hyperplasia, Bupivacaine, Pain, Recovery, localized blockade}, volume = {26}, Number = {3}, pages = {293-306}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.293}, url = {http://armaghanj.yums.ac.ir/article-1-3036-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-3036-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Azimpour, M and Fathi, M and Dezfulian, O}, title = {The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer\'s Mice}, abstract ={        Armaghane-danesh, Yasuj University of                                                                                   Original Article 1056 1056 Medical Sciences Journal (YUMSJ)     The Effect of Eight Weeks of Royal Jelly Consumption on Some of Apoptotic Indicators in Trimethyltin-Induced Alzheimer's Mice      Azimpour M, Fathi M*, Dezfulian O   Department of Physical Education, Lorestan University, Khorramabad, Iran   Received: 05 Sep 2020         Accepted: 10 Oct 2020   Abstract:   Background & aim: Given that Royal Jelly contains compounds that have beneficial effects on the central nervous system and neural functions, therefore, the aim of this study was to determine and evaluate the effect of Royal Jelly consumption on apoptotic indices in trimethyltin model of Alzheimer's disease.   Methods: In the present experimental study conducted in fall of 2018, 32 male Sprague-Dawley rats were included in the study. Twenty-four of them were induced by Alzheimer's induction by trimethyltin. The rats were then randomly divided into four groups: healthy last week, victim control last week, sham and royal jelly. The expression of P53, BAX, BCL-2 genes were measured by Real Time PCR technique. Data analysis was performed by Manova test and post hoc Scheffe at the significant level P<0.05 using SPSS software version 20.   Results: The findings of the present study indicated that the dependent variable P53 in the last week Alzheimer's group was more than the healthy groups in the last week and gel. Moreover, the dependent variable P53 in the sham group was more than the healthy groups in the last week and the gel. In the healthy group, the last week was less than sham and Alzheimer's last week. BCL-2 in the gel group was more than sham and healthy last week and Alzheimer's last week and in the healthy group last week was more than sham and Alzheimer's last week.   Conclusion: Trimethylmethine administration may be involved in selective neuronal death and mitochondrial apoptotic pathways in neurodegenerative disorders, and royal jelly supplementation may be used as an inhibitor of the internal pathway of apoptosis and to enhance neural function and neuronal regeneration in the present model.  }, Keywords = { Royal Jelly, Apoptosis Indicators, Alzheimer's Disease}, volume = {26}, Number = {3}, pages = {307-323}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.307}, url = {http://armaghanj.yums.ac.ir/article-1-2847-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-2847-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {SanaeiJahromi, M and Kavousi, F}, title = {Evaluation of the Effect of Valproic Acid on JAK/STAT Pathway, SOCS1, SOCS3, Bcl-xL, c-Myc, and Mcl-1 Gene Expression, Cell Growth Inhibition and Apoptosis Induction in Human Colon Cancer HT29 Cell Line}, abstract ={Abstract:   Background & aim: Cytokines are a large family of messenger proteins, which induce various cancers. Cytokines are mediated by Janus kinases (JAKs). Once activated, these kinases phosphorylate the STAT protein (signal transducers and activators of transcription, STAT), and STAT regulates the expression of genes involved in cell differentiation, proliferation, and apoptosis. Defects in the JAK / STAT pathway cause tumorigenesis and cancer. Improper expression of STAT genes impairs the expression and expression of Bcl-xL, c-Myc, Mcl-1, CCND1 and VEGF genes, resulting in uncontrolled cell proliferation and cancer. The aim of the present study was to determine the effect of valproic acid on the expression of JAK1, JAK2, STAT3, STAT5A, STAT5B, SOCS1, SOCS3, Bcl-xL, c-Myc and Mcl-1 genes, cell viability and induction of apoptosis in colon cancer. Cell line was HT29.   Methods: In the present experimental-laboratory study conducted in 2019, the HT 29 colorectal cancer cells were treated with valproic acid. MTT, flow cytometry and real-time techniques were used to determine cell viability, apoptotic cells and gene expression, respectively. The obtained data were analyzed using Prism Graph Pad 8 software.   Results: Valproic acid significantly inhibited cell growth, induced apoptosis, decreased expression of JAK1, JAK2, STAT3, STAT5A, STAT5B, Bcl-xL, c-Myc and Mcl-1 genes and increased the expression of SOCS1 and SOCS3 genes. Alteration in the expression of the above genes inhibited cell proliferation and induced apoptosis in the studied cancer cells.   Conclusion: VPA can induce apoptosis in colon cancer HT29 cell line through JAK/STAT pathway.     }, Keywords = { VPA, JAK/STAT, Colon Cancer, Apoptosis}, volume = {26}, Number = {3}, pages = {324-337}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.324}, url = {http://armaghanj.yums.ac.ir/article-1-3053-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-3053-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Sayyahi, J and Mobayen, H and Jafari, B and Jafari-Sales, A}, title = {Antibacterial Effects of Ethanolic Extracts of Ziziphus jujuba, Medicago sativa, Reum ribes and Hyssopus officinalis on Some Standard Gram-Positive and Gram-Negative Bacteria in Vitro}, abstract ={Background & aim: Currently, with increasing resistance to synthetic drugs, the demand for natural and safe alternatives to these types of medications has increased.  Therefore, the aim of the present study was to determine and evaluate the antibacterial effects ethanolic extracts of Ziziphus jujuba, Medicago sativa, Reum ribes and Hyssopus officinalis on some standard gram-positive and negative bacteria in vitro.   Methods: The present experimental study was conducted in 2019 in the microbiology laboratory of Islamic Azad University, Ahar Branch, Iran. Plants were identified by botanists after being collected from natural habitats. Extraction was performed by Soxhlet extractor and the antimicrobial effects of the extracts were determined by agar well diffusion and determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (MBC) on standard bacteria in vitro. The collected data were analyzed using analysis of variance and Chi-square.   Results: Z. jujuba and M. sativa plant extracts were effective on gram-negative bacteria and extracts of R. ribes and H. officinalis plants were effective on gram-positive bacteria, which with increasing the concentration of extracts. The antibacterial property extracts were dode dependent. MBC / MIC results indicated that Z. jujuba and M. sativa plant extracts were most susceptible to P. aeruginosa and E. coli and R. ribes and H. officinalis extracts were most susceptible to S. aureus and B. cereus.   Conclusion: Z. jujuba, M. sativa, R. ribes and H. officinalis plants had significant antibacterial effects, but to introduce these plants as antibacterial drugs requires more complete and comprehensive in vivo studies.  }, Keywords = { Standard Bacteria, Extracts, Antibacterial Effects, Gram-Positive, Gram-Negative}, volume = {26}, Number = {3}, pages = {338-350}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.338}, url = {http://armaghanj.yums.ac.ir/article-1-2601-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-2601-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Talebianpoor, MS and Bardania, H and Mansourian, M}, title = {The Effect of Podophyllotoxin as an Inducer of Apoptosis Using Molecular Docking Method}, abstract ={Background and aim: Podophyllotoxin is used as one of the main treatments for genital warts. It is a precursor of etoposide and teniposide, which is used in the treatment of various cancers. Despite a large number of cancer studies, the exact mechanism of podophyllotoxin remains unknown. Suppression of enzymatic activity of adult caspases occurs in cancer cells in the presence of specific members of the inhibitor of apoptosis proteins (IAPs) family such as X-linked inhibitor of apoptosis protein (XIAP), cellular inhibitor of apoptosis proteins (cIAP1), and Survivin. By specifically binding a second mitochondria-derived activator of caspases-mimetics (Smac-mimetics) to negative apoptosis regulators, inhibition of IAPs-mediated caspases is eliminated and apoptosis is induced. The aim of the present study was used to determine the mechanism of action of podophyllotoxin as an inducer of apoptosis using molecular docking method.   Methods: The present bioinformatics study was conducted in 2020. Molecular docking method was used to calculate the molecular interaction of podophyllotoxin with proteins associated with initiator and effector caspases including baculovirus IAP repeat (BIR3) of XIAP / cAIP1 and Survivin, as well as B-cell lymphoma-2 (Bcl-2) and epidermal growth factor receptor (EGFR). The theoretical binding site of podophyllotoxin on these anti-apoptotic proteins was determined as an inhibitor to obtain information on the initial interaction, free binding energy and inhibition constant by molecular docking method. The collected data were analyzed using different software and compared with the results of related articles.   Results: The proapoptotic activity of podophyllotoxin as an apoptotic-inducing agent is associated with the signaling pathways of caspases 3, 7, 8, and 9. The key activation mechanisms of these caspases may be due to podophyllotoxin binding and induction of conformational changes at active sites of the XIAP / cAIP1-BIR3 and Survivin located near or at the same Smac-mimetics binding site. Three strong hydrogen bonds with the amino acids Tyr108, Ser117 and Glu118 play important roles in the stabilization of the Bcl-2-podophyllotoxin complex. Podophyllotoxin, similar to EGFR inhibitors, forms several hydrophobic interactions and two strong hydrogen bonds with Thr830 and Met769 with a bond-free energy of -7.85 kcal / mol and an inhibition constant of Ki = 1.76 µM.   Conclusion: Induction of apoptosis in cancer cells by podophyllotoxin can be attributed to several different mechanisms. Predicted binding conformations showed that podophyllotoxin had valuable inhibitory potential. Therefore, podophyllotoxin may be considered as an effective anticancer agent for further research into drug development.}, Keywords = {   Podophyllotoxin, Cancer, Apoptosis, Molecular docking }, volume = {26}, Number = {3}, pages = {351-370}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.351}, url = {http://armaghanj.yums.ac.ir/article-1-3032-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-3032-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Nazari, I and Makvandi, B and SerajKhorram, N and Heidarei, A}, title = {Comparison of the Effectiveness of Group Gestalt Therapy and Selection Theory on Marital Intimacy in Women with Breast Cancer in Yasuj, Iran}, abstract ={Background & aim: Cancer is one of the life-threatening diseases and causes an increase in emotional disorders and a significant decrease in the quality of life in patients. Therefore, the aim of the present study was to determine and compare the effectiveness of group gestalt therapy and selection theory on marital intimacy in women with breast cancer in Yasuj, Iran.   Methods: The present study used and experimental design with pretest-posttest method with control group, which was conducted during 2019-2020. The statistical population of the present study was 60 women using purposive non-random sampling method who were randomly divided into experimental and control groups (20 women in each group). Thompson and Walker marital intimacy questionnaire was used to collect data. The experimental groups underwent group gestalt therapy (10 sessions of 60 minutes) and selection theory (10 sessions of 60 minutes), but the control group did not receive any intervention. Data were analyzed using analysis of covariance.   Result: The results indicated that both group gestalt therapy and selection theory were effective in increasing marital intimacy in women with breast cancer in Yasuj (P = 0.0001). There was no significant difference in breast size in Yasuj, Iran (P = 0.0001). These results continued until the follow-up stage.   Conclusion: It can be concluded that group gestalt therapy and selection theory could be used to increase marital intimacy in women with breast cancer. These therapies could help improve the performance of women with breast cancer in improving the level of marital intimacy.  }, Keywords = { Gestalt Therapy Group, Choice Therapy, Marital Intimacy, Cancer.}, volume = {26}, Number = {3}, pages = {371-386}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.371}, url = {http://armaghanj.yums.ac.ir/article-1-3003-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-3003-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Alimoradi, H and Nazari, M and JafariNodoshan, R and AjdaniA,}, title = {An Investigation on the Effects of Occupational Noise Caused by Harmful Steel Process on Psychological and Cognitive Components of Employees in Isfahan Steel Industry}, abstract ={Background & aim: Sound-induced psychological disorders include anxiety, stress and restlessness, sleep disturbances and impaired mental function and information processing. Noise pollution in addition to the adverse effects on the physical health of people in terms of quality can also create annoying conditions for people who are exposed to it. The aim of the present study was to determine and investigate the effects of occupational noise caused by harmful steel process on the psychological and cognitive components of employees in Isfahan steel industry.   Methods: The present research was a case-control study. In order to investigate the relationship between variables, disturbances caused by steel industry noise in 1000 employees of Isfahan steel industry in 2020 was completed. Sampling was done randomly. All samples in the control group were matched with the exposed group in terms of demographic characteristics. The instruments of this study were DASS questionnaire, CPI, personality types and the standard measurement method 9612 was used to obtain objective noise. The collected data were analyzed using Chi-square, independent t-test and Fisher tests.   Results: Based on the findings of the study, age factor on depression, marital status factor on anxiety and shift factor had a significant effect on staff stress (p <0.05). There was no significant difference in anxiety and depression variables between case and control groups (p <0.05), but the mean of stress variable in case group (66.1 ± 40.11) was significantly higher than control group (89.12 ± 59.1 (p <0.001). This indicated that the intensity of the sound was more effective in increasing the stress level of workers.   Conclusion: Based on the findings, it can be concluded that due to the positive and significant relationship between sound intensity and cognitive and mental components in the case group, it is necessary to take effective preventive measures to prevent psychological harm and maintain workers' health in this industry.      }, Keywords = {Standard 9612, Noise, Moods, Cognitive Processing, Depression, Personality Type}, volume = {26}, Number = {3}, pages = {387-405}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.387}, url = {http://armaghanj.yums.ac.ir/article-1-2917-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-2917-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Mankhian, Alireza and Shariat, Afsoo}, title = {Prevalence of Occult Hepatitis B Infection Among Blood Donors with HBsAg Negative and HBcAb Positive by Real Time PCR in South of Iran}, abstract ={Abstract   Background & aim: Occult hepatitis B virus infection in blood donors threats the safety of the blood supply.  It is characterized by detection of low viral DNA in the serum subjects who have negative test for Hepatitis B surface antigen (HBsAg). The aim of this study was to assess the prevalence of occult hepatitis B virus infection among HBsAg negative and HBcAb positive in blood donors of Bushehr blood transfusion organization       Methods: The present cross-sectional study was conducted on 1000 blood donors referring to Bushehr blood transfusion organization between November 2017 and January 2019.  All subjects were negative for HBsAg and were tested for HBcAb by use of ELISA technique. The samples that were positive for HBcAb marker also analyzed for the presence of viral DNA by Real time PCR. The data were analyzed using SPSS Ver. 22.0 and chi-square tests Results: 30 (3%) out of 1000 samples were HBcAb positive. Of these 30 samples, 29 (97%) were male and 1 (3%) was female. A significant association was found between level of education and HBcAb positive (p=0.028). Also, there was a significant association between marital status and HBcAb positive (p=0.001). HBV-DNA was not detected in any of the cases with isolated HBcAb. The results showed no significant relationship between HBcAb positive and occult hepatitis B virus infection (p> 0.05) Conclusion: Although the viral genome was not present in any of the HBcAb positive and HBsAg negative blood donors in Bushehr Blood Transfusion Organization, but to improve the health of donated blood, it is recommended that HBcAb testing and PCR method be used to determine the prevalence of occult hepatitis B infection in HBsAg-negative blood donors in a wider range of blood donors. Therefore, serological HBsAg testing alone cannot detect occult hepatitis B infection in blood donors}, Keywords = {Occult hepatitis B infection, Anti-HBc antibody, Blood donors, Bushehr}, volume = {26}, Number = {3}, pages = {406-416}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.406}, url = {http://armaghanj.yums.ac.ir/article-1-2945-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-2945-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Ghaffari, P and Jansar, R and Zol-Adl, M and Ghadami, R}, title = {Prevalence of Human Papillomavirus in Women with Abnormal Pap smear Referred to Shahid Mofatteh Clinic by Multiplex PCR & Reverse Dot Blot Hybridization in Yasuj, Iran}, abstract ={    Background & aim: Human papillomavirus is the most common sexually transmitted disease and the main risk factor for malignant and malignant lesions in the cervix. The aim of the present study was to determine and evaluate the prevalence of human papillomavirus in women with abnormal pap smear referred to Shahid Mofatteh specialized clinic by Multiplex PCR & Reverse Dot Blot Hybridization in Yasuj, Iran.   Methods: The present descriptive-analytical study was conducted during the years 2015-2016. A total of 67 abnormal cervical cytology specimens including 51 ASC-US specimens, 9 LSIL specimens and 7 HSIL specimens were collected and analyzed by Multiplex PCR & Reverse Dot Blot Hybridization. The collected data were analyzed using chi-square test   Result: The overall prevalence of human papillomavirus (HPV) was 61.2%. 36 (87.8%) women were infected with high-risk types of human papillomavirus, 26 (63.4%) with low-risk types and 2 (4.9%) with unknown types. The most common high-risk types were HPV 39 (43.9%), HPV66 (31.7%), HPV31 (26.8%) and HPV18 (14.6%), respectively. HPV16 was detected in only 2 samples (4.9%).   Conclusion: The results of the present study indicated a high prevalence of papillomavirus infection in women with abnormal Pap smear. In addition, different high-risk genotypes of this virus were identified compared to other studies in Iran. Further samples from wider geographical areas are needed to study the molecular epidemiology and genotypes of human papillomavirus.  }, Keywords = { Human Papillomavirus, High Risk Type, Abnormal Pap smear, PCR}, volume = {26}, Number = {3}, pages = {417-428}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.417}, url = {http://armaghanj.yums.ac.ir/article-1-2920-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-2920-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} } @article{ author = {Jamshidi, A and Sadat, SA and RaeganShirazinejad, A and Rezaei, S and Moradian, SA}, title = {Analysis of Waste Management Situation in Yasuj, Iran}, abstract ={Abstract:   Background & aim: Population growth, consumption pattern change, economic development, income change, urbanization and industrialization have increased waste production and diversity of waste. Knowledge of sources and types of waste along with information about the composition and production rate is the basis for the design and operation of waste management systems. Therefore, the purpose of the present study was to determine and analyze the situation of waste management in Yasuj, Iran.   Methods: The present descriptive cross-sectional study was conducted in 2010 in Yasuj. In order to quantitatively analyze and determine the percentage of components of Yasuj municipal waste, the number of samples was estimated according to ASTM instructions and samples were taken from the trucks entering the landfill on different days of the week. Data were analyzed using descriptive statistics and Excel software. Results: The average per capita waste generated in Yasuj was calculated to be 1.03 kg per person per day and food waste, plastic, paper and cardboard were the maximum components of solid waste in Yasuj, respectively. The average density of municipal solid waste was 215 kg / m3 and the moisture content was 47%.   Conclusion: According to the studies conducted in the field of waste management in the study area and the existence of significant amounts of recyclable and economically valuable components such as perishable waste, plastics and paper and cardboard, attention to their recovery in the waste management system of Yasuj city. It is suggested that in addition to economic benefits, part of the costs of waste management be offset. Evidently, in order to maintain the quality of recycling components, training people to separate waste at the source of production and create a labor market for investors is also recommended.  }, Keywords = { Municipal Solid Waste, Solid Waste Generation per Capita, Recycling}, volume = {26}, Number = {3}, pages = {429-441}, publisher = {Yasuj University Of Medical Sciences}, doi = {10.52547/armaghanj.26.3.429}, url = {http://armaghanj.yums.ac.ir/article-1-3005-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-3005-en.pdf}, journal = {Armaghane Danesh}, issn = {1728-6506}, eissn = {1728-6514}, year = {2021} }