per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
282
294
article
Comparison of Two Intensities of Aerobic Training (low intensity and High Intensity) on Expression of Perlipin 2 Skeletal Muscle, Serum Glucose and Insulin levels in Streptozotocin-Diabetic Rats
M Ghafari
ghafari.mehdi@gmail.com
1
E Banitalebi
banitalebi.e@gmail.com
2
M Faramarzi
Md.faramarzi@gmail.com
3
A Mohebi
ab-mohebi@vet.sku.ac.ir
4
Department of Exercise Physiology, University of Shahrekord. Shahrekord, Iran,
Department of Exercise Physiology, University of Shahrekord. Shahrekord, Iran,
Department of Exercise Physiology, University of Shahrekord. Shahrekord, Iran,
Department of Clinical Sciences, University of Shahrekord, Shahrekord, Iran
Abstract
Background & aim: Lipid metabolism disorder plays an important role in insulin resistance in skeletal muscle and lipid drop proteins such as perlipine 2 (PLIN2) are effective in regulating intracellular fat metabolism. One of the suggested pathways for the effects of endurance activity in metabolic diseases is the effect of physical activity on intramuscular. Therefore, the purpose of this study was compare the intensity of aerobic exercise intensity (low intensity and high intensity) on expression of PLIN2 skeletal muscle, serum glucose and insulin levels in streptozotocin-diabetic rats.
Methods: In this experimental study, 24 male Wistar rats were randomly divided into three groups of 8, including two intervention groups (low intensity endurance training group and high intensity continuous exercise group) and one control group. After induction of diabetic rats by injection streptozotocin (55 mg / kg body weight), Intraperitoneally, endurance training was applied for eight weeks, three sessions per week in diabetic rats. Exercise intensity in the low-intensity group was equal to 5-8 m / min (equivalent to 50-60% Vo2max), the intensity of training in a high intensity training group was equivalent to a speed of 22-25 m / min (equivalent to 80% Vo2max) and the control group did not receive intervene in this time. Relative protein expression of PLIN2 was performed using western blot technique. Data were analyzed by one-way ANOVA and Tukey's post hoc test.
Results: The results of the intergroup comparison revealed a significant difference among three groups in the PLIN2 variables (p = 0.037). The results of post hoc test showed a significant increase in PLIN2 in high intensity training diabetic group compared to the control group (p = 0.033) However, there was no significant difference in PLIN2 level in the low exercise group compared to the control group (p = 0.18). Also, there was no significant difference between the low intensity and high intensity training groups (p = 0.66). Serum glucose and insulin levels were significantly different between diabetic control groups and low intensity and high intensity training (p = 0.001). This difference was between the high intensity training group with low intensity group (p = 0.04, p = 0.01), diabetes control (p = 0.001, p = 0/000), respectively.
Conclusion: Regarding the results of the study, modulation effects of high intensity endurance exercises on increasing the expression of PLIN2 in diabetic specimens were noted.
http://armaghanj.yums.ac.ir/article-1-1843-en.pdf
Diabetes
PLIN2
endurance training
intramuscular triglycerides
insulin resistance
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
295
310
article
The Effect of Bone Marrow Mesenchymal Stem Cell Culture in the Treatment of Azoospermic Infertility induced by Busulfan Balb / C mice
A Mozafar
mozafar77@yahoo.com
1
D Mehranani
mehrabad@sums.ac.ir
2
A Vahdati
avahdatim@yahoo.com
3
SE Hosseini
ebrahim.hossini@yahoo.com
4
M Forouzanfar
mforozanfar@yahoo.com
5
Department of Biology, Islamic Azad University, Fars, Iran
Stem Cell Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Department of Biology, Islamic Azad University, Fars, Iran
Department of Biology, Islamic Azad University, Fars, Iran
Department of Biology, Marvdasht Branch, Islamic Azad University, Marvdasht, Iran
Abstract
Background & aim: Prescribing chemotherapy drugs in patients with cancer can be the mainstay of infertility. Therefore, the aim of this study was to investigate The Effect of Bone Marrow Mesenchymal Stem Cell Culture in the Treatment of Azoospermic Infertility induced by Busulfan Balb / C mice
Abstract
Background & aim: Prescribing chemotherapy drugs in patients with cancer can be the mainstay of infertility. Therefore, the aim of this study was to investigate The Effect of Bone Marrow Mesenchymal Stem Cell Culture in the Treatment of Azoospermic Infertility induced by Busulfan Balb / C mice
Methods: In this experimental study, 18 mice of Balb-C race were randomly divided into control, azoospermic and secreta groups. The animals in the control group did not receive any drug treatment. To stop spermatogenesis and induction of azospermide, a dose of busulfan (10 mg / kg body weight) was injected to azoospermic and cyclic rats at intervals of 21 days. 35 days after the last injection of busulfan, the medium used for the culture of mesenchymal stem cells of the bone marrow was injected into the testis of the rat secreta group. Eight weeks after inoculation, the testicles of all animals were separated and histologically and histomorphologically examined. Data were analyzed by one-way ANOVA.
Results: Histologic findings showed that in the azoospermic group, the spermatogenic cells were significantly reduced, and the vacuoles were observed in the germinal epithelium. After treatment with secreta, the epithelium and spermatogenesis were observed. Also, histomorphometric findings showed that cell thickness and area, total diameter, cross-sectional area and spermatogenesis index of seminal tubes were increased in the secreta group compared to the azoospermic group (p <0.001), but decreased compared to the control group (P <0.05). Also, the number and density of seminal tube in control group and secreta decreased compared to Azospermic group (p <0.001). There was no significant difference between lumen diameter and area of menises in all three groups (p>0.05).
Conclusion: The media used in the cultivation of bone marrow mesenchymal stem cells (Secreta) can cause spermatogenesis back in busulfan-induced azoospermic mice. These findings can be attributed to previous findings in male infertility treatment.
Methods: In this experimental study, 18 mice of Balb-C race were randomly divided into control, azoospermic and secreta groups. The animals in the control group did not receive any drug treatment. To stop spermatogenesis and induction of azospermide, a dose of busulfan (10 mg / kg body weight) was injected to azoospermic and cyclic rats at intervals of 21 days. 35 days after the last injection of busulfan, the medium used for the culture of mesenchymal stem cells of the bone marrow was injected into the testis of the rat secreta group. Eight weeks after inoculation, the testicles of all animals were separated and histologically and histomorphologically examined. Data were analyzed by one-way ANOVA.
Results: Histologic findings showed that in the azoospermic group, the spermatogenic cells were significantly reduced, and the vacuoles were observed in the germinal epithelium. After treatment with secreta, the epithelium and spermatogenesis were observed. Also, histomorphometric findings showed that cell thickness and area, total diameter, cross-sectional area and spermatogenesis index of seminal tubes were increased in the secreta group compared to the azoospermic group (p <0.001), but decreased compared to the control group (P <0.05). Also, the number and density of seminal tube in control group and secreta decreased compared to Azospermic group (p <0.001). There was no significant difference between lumen diameter and area of menises in all three groups (p>0.05).
Conclusion: The media used in the cultivation of bone marrow mesenchymal stem cells (Secreta) can cause spermatogenesis back in busulfan-induced azoospermic mice. These findings can be attributed to previous findings in male infertility treatment.
http://armaghanj.yums.ac.ir/article-1-1647-en.pdf
Mesenchymal Stem Cells
Secreta
Busulfan
Azoospermia
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
311
324
article
Effect of Eight Weeks Aerobic Training on Oxidative Stress Markers in Rats Exposed to Electromagnetic Microwave Radiation Emitted from Wi-FiRouters
B Pourfazeli
1
A Azamian Jazi
azamianakbar@yahoo.com
2
M Faramarzi
3
M J Mortazavi
4
Department of Physical Education and Sport Sciences, Shahrekord University, Shahrekord, Iran
Department of Physical Education and Sport Sciences, Shahrekord University, Shahrekord, Iran
Department of Physical Education and Sport Sciences, Shahrekord University, Shahrekord, Iran
Ionizing and NonIonizing Radiation Protection Research Center (INIRPRC), Shiraz University of Medical Sciences
Abstract
Background & aim: Exposure to electromagnetic waves can lead to oxidative stress. On the other hand, the antioxidant system function of the body increases with regular exercise and reduces oxidative stress. The aim of this study was to investigate the effect of eight weeks aerobic training on oxidative stress markers in rats exposed to electromagnetic microwave radiation emitted from the Wi-Fi routers.
Methods: In this experimental study, 26 male Wistar rats (8 weeks old) with a weight range of 200±20 g were randomly divided into four groups including: control, radiation, exercise, and radiation + training. The main training program consisted of 8 weeks (one session a day and five days a week) running on a treadmill for animals at 40 to 60% max speed, and the protocol included one hour of exposure to a 45.2 GHz rays of Wi-Fi modem for 8 weeks. Before and 48 hours after the main interventions, blood samples were taken from all groups. Plasma superoxide dismutase (SOD) and glutathione peroxidase (GPX) levels were measured by ELISA and validated by MDA and MDA kits with TBA method. Data was analyzed using one way ANOVA, Tukey and T-test.
Results: The results of one-way ANOVA showed that there was a significant difference among the different groups in the study. Eight weeks of exposure to Wi-Fi radiation caused a decrease in plasma levels of SOD and GPx and an increase in MDA. On the other hand, eight weeks of aerobic exercise increased plasma levels SOD and GPx, and reduced MDA. Tukey's test showed that there was a significant difference between SOD and GPx in all groups, except for those with radiation + (p = 0.099 and p = 0.073). In MDA, the difference was significant among all groups, except for the aerobic group + aerobic training group with aerobic training and control groups (p = 0.331 and p = 0.717). The results of t-test showed a significant difference between pre-test and post-test of all variables in the research.
Conclusion: It seems that regular aerobic exercise exercises can have beneficial effects on the antioxidant system and modulate the oxidative stress indices induced by the Wi-Fi radiation.
http://armaghanj.yums.ac.ir/article-1-1834-en.pdf
Oxidative stress
Radiation
Aerobictraining
Antioxidant system
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
325
336
article
The effect of Hydroethanolic Extract of Tragopogon Pratensis L. leaves on T3, T4 and TSH Serum Levels in Male Rats Induced with Lead Acetate
S Kiani
info_salimeh kiani@gmail.com
1
H Vazini
hossein_vazini@yahoo.com
2
N Mirazi
mirazi205@gmail.com
3
Department of biology, Islamic Azad University , Hamedan Branch, Hamedan, Iran,
Department of Nursing, Islamic Azad University , Hamedan Branch, Hamedan, Iran,
Department of Biology, Bu-Ali Sina University, Hamedan, Iran
Background & aim: Thyroid hormones play an important role in controlling and maintaining homeostasis. In this study, the effect of Tragopogon pratensis L.) was investigated on serum thyroid hormones levels in rats receiving acetate.
Methods: In this experimental study, 36 male rats were divided into 6 groups including control, lead acetate and treatment groups 1, 2 and 3 (lead acetate + extract of Tragopogon pratensis L. at doses of 200, 400 and a high dose of 800 mg / kg) and the positive control group receiving Tragopogon pratensis L. extract (400 mg / kg dose). At the end of the experiments, after anesthesia, blood samples were taken from the heart of the animals and the serum levels of thyroid hormones TSH, T4, and T3 were measured. Data were analyzed using ANOVA and Tukey tests.
Results: A Significant decreases were seen in serum levels of T3, T4 and TSH in the acetate receiving groups decreased significantly compared to the control group (p <0.001). But the treated groups with Tragopogon pratensis L. extract significantly increased serum levels of thyroid hormones compared to those receiving acetate.
Conclusion: Hydroalcoholic extract of Sheng increased thyroid hormones to normal levels in lead acetate receiving mice. It is believed that the chemical compounds present in the extract of this plant can protect the thyroid tissue against the destructive effects of lead acetate.
http://armaghanj.yums.ac.ir/article-1-1599-en.pdf
Lead acetate
Thyroid Hormones
Rat
Tragopogon pratensis
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
337
349
article
Effects of Metformin and Ginger Rhizome Extract on the Pituitary - Gonad Function in Adult Female Rats With Polycystic Ovary Syndrome
M Foroozandeh
ebrahim.hossini@yahoo.com
1
SE Hosseini
ebrahim.hossini@yahoo.com
2
Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran,2Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran.
Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran,2Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran.
Abstract:
Background & aim: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of infertility in women. Due to the prevalence of PCOS in worldwide, the aim of this study is defined to compare the impact of metformin with ginger on pituitary-gonad function in PCOS adult female rats .
Methods: In this experimental study72 adult female rats were used. The rats were divided in a control of PCOS and 7 experimental groups of PCOS receiving metformin alone at 150 mg / kg, ginger with 100, 200 and 300 mg/kg doses, and ginger with doses of 100, 200 and 300 mg/kg with metformin at a dose of 150 mg / kg. All prescriptions were performed for 28 days in a gavage. Blood samples were taken from animals to measure the FSH, LH, estrogen, progesterone and testosterone hormones, their ovaries were removed and follicular tissue sections were counted. Statistical data were analyzed using ANOVA and nhk; k tests.
Results: Letrozole induced PCOS increased follicles of atritic, testosterone, estrogen and other follicles and FSH levels at the level of P<0.01, and metformin and ginger alone and with each other reduced the number of atritic follicles and increased other follicles and FSH levels at p <0.01. Also, consumption of metformin and ginger significantly decreased testosterone and estrogen levels at the level of p <0.01 compared to the control group.
Conclusion: Administration of metformin and extract of rhizome ginger alone or with each other increases FSH and primary follicles, primary, secondary, graviflower, yellow corpuscles, and reduction of atritic follicles in animals with polycystic otitis media due to letrozole administration, as well as metformin and ginger extract. There is no significant effect on the level of estrogen and testosterone hormones in these animals, while the simultaneous administration of both decreases estrogen and testosterone levels in animals with polycystic ovarian dysfunction.
.
http://armaghanj.yums.ac.ir/article-1-1848-en.pdf
polycystic ovary
metformin
ginger rhizome
progesterone
testosterone
estrogen
FSH
LH
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
350
363
article
The Effect of Group Based Hope Therapy on Resiliency of Mothers of Children with Autism Spectrum Disorder
A Salimi
rezadavarniya@yahoo.com
1
A Abbasi
rezadavarniya@yahoo.com
2
K Zahrakar
rezadavarniya@yahoo.com
3
B Tameh
rezadavarniya@yahoo.com
4
R Davarniya
rezadavarniya@yahoo.com
5
1Department of Counseling, Kharazmi University, Tehran, Iran
2Department of Counseling, Allameh Tabatabai University, Tehran, Iran,
1Department of Counseling, Kharazmi University, Tehran, Iran
3Department of Educational Psychology, Science and Research Branch, Islamic Azad University, Tehran, Iran
1Department of Counseling, Kharazmi University, Tehran, Iran,
Abstract
Introduction: Autism spectrum disorder has been characterized by problems in social function, communication and having repetitive and stereotype behaviors. Due to ample problems of such children, families and particularly mothers suffer from much tensions and psychological pressures. The present research was designed and conducted by the aim of investigating the effect of group-based hope therapy on resilience in mothers of children with autism spectrum disorder.
Materials and method: The present research was a semi-experimental intervention which was conducted by using a pretest-posttest with control group design. The research population included all the mothers of children with autism spectrum disorder referring to Nedaye-Asr rehabilitation center (specialized for autism children), whose children were diagnosed to have autism disorder by psychiatrist, pediatrician and clinical psychologist. 30 mothers with autistic children were selected by available sampling method and were assigned into experiment and control groups through random assignment method. For collecting the data, the Connor- Davidson Resiliency Scale (2003) was used. After taking the pretest, subjects of the experiment group received 8 sessions of group-based hope therapy, while the control group were put in the waiting list. After finishing the sessions, the posttest was taken from both groups. The research data were analyzed by univariate covariance analysis test (ANCOVA) by using SPSS v18.
Results: The results of single-variable covariance analysis showed a significant difference in the resilience of the experimental and control group in the post-test (p <0.01). In other words, group hoped-up sessions increased the resilience of mothers in the intervention group (F = 121.76).
Conclusion: It is recommended that Autistic Children's Centers across the country use an Interventional Hope Therapy Package to reduce psychological problems and promote the mental health of their parents.
http://armaghanj.yums.ac.ir/article-1-1763-en.pdf
Autism Spectrum Disorder
Hope
Therapy
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
364
374
article
Effect of the Implementation of a Theory-Based Educational Program on the Prevention of Cardiovascular Diseases in Women Aged 30 to 45
S Darabi
1
K Karimzadeh Shirazi
karimzadehshirazi@yahoo.com
2
M Akbar Tabareti
3
Mousavizadeh SA
4
S Zamani
5
Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran,
Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran,
Department of Nutrition, Mazandaran University of Medical Sciences, Sari, Iran
Social Determinants of Health Research Center, Yasuj University of Medical Sciences, Yasuj, Iran,
Nutrition Department, Shaheed Damedeh Health Center, Yasuj University Of Medical Sciences, Yasuj, Iran.
Abstract
Background & aim: Cardiovascular disease is a non-communicable disease that is caused by several factors. Today, cardiovascular disease is the main cause of inability and mortality in many countries, so that prevention is one of the issues discussed by the World Health Organization. The aim of this study was to determine the effect of educational intervention based on health belief model on prevention of cardiovascular diseases in women aged 30-30 years old in the city of sisakht.
Methods: This clinical trial was conducted on 137 women aged 30-45 years who attended the Sisakht Health Center. The participants were selected through systematic random sampling. Women population was identified and divided into 6 blocks. Subjects were randomly selected according to the population of each block. Information collected was conducted by inventory and registration of health food three days before and two months after the training. Educational methods included lectures, questions and answers, counseling, and educational tools such as pamphlets, posters, instructional manuals, and film was used. Based on the analysis, the educational content was prepared. The intervention program included 6 educational sessions based on the health belief model which was held weekly by a meeting. Data were analyzed using independent t-test, paired t-test, correlation and ANOVA.
Results: Based on the results, educational intervention significantly increased the knowledge scores and health belief model structures, except barriers structure (p <0.05) were perceived. Mean consumption of calories, carbohydrates, lipid, fatty acids, salt and bread and cereal groups decreased, and milk and dairy and vegetable groups was increased (P <0.05).
Conclusion: Regarding the effective role of educational intervention in increasing awareness and improving the beliefs of women aged 30-45 years, it can be concluded that education in these women is very effective in promoting cardiovascular disease prevention.
http://armaghanj.yums.ac.ir/article-1-1715-en.pdf
education
health belief model
nutritional behavior
cardiovascular disease
women
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
375
389
article
Evaluation of Patient-Related Nursing Care with Standards in Intensive Care Unit (ICU)
H Bayatmanesh
hbayatmanesh@gmail.com
1
M Zagheri Tafreshi
tafreshi@sbmu.ac.ir
2
H Mnoochehri
3
A Akbarzadeh Baghban
akbarzad@gmail.com
4
Department of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Department of Nursing & Midwifery, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Department of Management Health an Treatment Services, Shahid Beheshti University of Medical Sciences, Tehran, Iran,
Department of Statistical, Shahid Beheshti University of Medical Sciences, Tehran, Iran
Abstract
Background & aim: Improving the quality of health care services is one of the main concerns of organizations providing health services. Patient safety means is the absence of any damage caused by the provision of health services. In the intensive care unit, due to complications of the patient's condition and the treatment process, the chance of occurrence of unexpected errors and events is maximized and serious attention is required . The purpose of this study was to determine the level of compliance of patient-related nursing care with standards in intensive care units.
Methods: In this descriptive study, 1998 nursing care associated with patient safety were assessed during the morning shift function of 54 nurses in three Intensive care unit of selected hospitals of Yasuj University of Medical Sciences using a researcher-made checklist containing 37 terms and 6 domains in winter 2015. These areas include the initial acceptance and evaluation of the patient, the correct procedure in the correct location of the patient's body, avoiding inappropriate connections between the tubes and the patient's catheter, preventing the patient falling down, preventing ulcer and nosocomial infections. The checklist after determining the face validity and content (96% = CVI) and reliability by means of calculating the agreement coefficient between viewers (99% = ICC), via observing the performance by the researcher in morning shifts was completed for 54 nurses. Collected data were analyzed using Descriptive statistics.
Results: In view of the performance of 54 nurses in intensive care units, the average level of compliance of patient-related nursing care in comparison with the checklist was less than 100 points which was unfaroble(46.75). The highest correlation with the patient's avoidance domain was relatively favorable (50.25) and the lowest level was related to the area of undesirable subsoil prevention (1.87).
Conclusion: The compliance rate of patient-related nursing care in ICU is far from standards. The managers of the area of treatment in order to improve the quality of nursing care provided by the nurse in relation to patient safety indicators in the intensive care unit and, consequently, to increase the safety of patients in order to prevent their injury as a result of the provision of these care, and regular monitoring of nursing care and continuing education programs will be more emphasis.
http://armaghanj.yums.ac.ir/article-1-1752-en.pdf
Patient Safety
Intensive Care Unit
Nursing care
Assessment.
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
390
404
article
Eight-week aerobic training effects on Apelin-13 and insulin resistance in overweight men
R Soori
soorirahman@yahoo.com
1
MR Asad
asad_mohammadreza@yahoo.com
2
M Yari
Yari@gmail.com
3
M Rastegar moghadan mansouri
rastegar.moghadam.mansouri@gmail.com
4
Department of Exercise Physiology, University of Tehran, Tehran, Iran
Department of Exercise Physiology, Payame Noor University, Karaj, Iran,
Department of Exercise Physiology, Payame Noor University, Karaj, Iran,
Department of Exercise Physiology, Researcher of Iranian Research Center on Aging, University of Social Welfare and Rehabilitation Sciences, Tehran, Iran.
Background & aim: Obesity as an epidemic which is associated with excessive accumulation of adipose tissue that secretes many hormones such as applein. Applein is an adipocytokine that increases its level in obesity. Changes in the level of apelin in response to aerobic exercise are not well defined. Therefore, the purpose of this study was to determine the effect of eight weeks of sub-maximal aerobic training with intensity of 50 to 60% of maximum heart rate on serum apelin-13 and insulin resistance in overweight men.
Methods: The present study was a quasi-experimental research. A total of 26 male overweight subjects with a body mass index of 27-30 kg / m2 were selected and randomly assigned to the subgroups and control aerobic exercise groups after the request was announced and adjusted to the entrance criteria. The aerobic training group under-maxed rrun out the training program for 30 sessions in an eight-week interval (3 sessions per week with an intensity of 50-70% of maximum heart rate).Body mass index, maximum oxygen consumption and blood sampling were performed and 24 hours after the last training session, the evaluations were repeated. Data were analyzed by statistical tests.
Results: The results of this study showed a significant decrease in body weight and body fat (p <0.05). Also, maximum oxygen consumption was significantly increased (p = 0.0001). However, indices of insulin resistance and Applein 13 did not show any significant changes. In addition, there was a direct and significant correlation between apelin 13 indices with anthropometric indices and glycosylated hemoglobin (p <0.05).
Conclusions: The internal factors of exercise practice, the intensity of aerobic exercise, have a significant effect on the anthropometric characteristics of overweight individuals, but not enough for significant changes in the levels of Applein 13 and insulin resistance. It is recommended that exercises be carried out over a longer period of time and more intensively so that the risk of developing type 2 diabetes and cardiovascular disease in people with overweight is reduced and controlled.
http://armaghanj.yums.ac.ir/article-1-1552-en.pdf
Applein -13
Aerobic exercise
Insulin resistance
Overweight
per
Yasuj University Of Medical Sciences
Armaghane Danesh
1728-6506
1728-6514
2017-08
22
3
405
418
article
Investigation of Liraglutide Effects on Changes of Uterine Tissue, Estradiol and FSH Hormones in NMRI Mice
S Atashnezhad
sara.atashnezhad@srbiau.ac.ir
1
N Hayati Roudbari
hayati@srbiau.ac.ir
2
S Mohammadi Gorji
kazem_parivar@yahoo.com
3
K Parivar
siminmohamady@gmail.com
4
1Department of Biology, Azad University Science and Research Branch, Tehran, Iran
1Department of Biology, Azad University Science and Research Branch, Tehran, Iran
2Department of Biology, Azad University, Sari, Iran
1Department of Biology, Azad University Science and Research Branch, Tehran, Iran
Abstract
Background & aim: Liraglutide has used for treatment of obesity and type 2 diabetes, which are main factors of infertility. Regarding that, uterus as the most important organ reproductive system is under vulnerable, particularly by chemical drugs, the purpose of this research was to investigated the effects of Liraglutide on uterine tissue changes and Estradiol and FSH hormones in NMRI mice in In vivo condition has been investigated.
Methods: This experimental study was performed on 28 adult NMRI female rats (8 to 12 weeks old) weighing between 25 and 30 grams. Mice were randomly divided into four groups (seven) including control, sham and two experimental groups. The control group was no injected and the sham and experimental groups 1 and 2 respectively received a solvent (distilled water) and liraglothedi at doses of 0.6 mg / kg and 1.8 mg / kg respectively. The injections were subcutaneously administered daily and in one hour. After 30 days of injection, the mice were deeply anesthetized by the ether and blood was removed from heart. After staining, samples were examined by optical microscopy. The collected data were analyzed using one-way ANOVA and Tukey's test.
Results: The weight of the mice in the experimental groups 1 and 2 significantly (p <0.01) and (p <0.01) compared with control and sham groups has decreased. Also, the thickness of the uterus (from the lumen to the last layer) and the diameter of the lumen showed a significant decrease (p <0.05) and (p <0.01) in the experimental groups. A significantly decreased was seen on endometrial thickness in the experimental groups 1 and 2 (p <0.01) and (p <0.001). Also, the thickness of primer in the experimental group also decreased significantly (p <0.05) in comparison with the control group. In addition, using the drug the number of uterine glands in experimental groups 1 and 2 showed a significant increase (p <0.05) and (p <0.01), and their diameter increased in both groups. Also, estradiol and FSH levels were decreased and increased, respectively.
Conclusion: Treatment with liraglutadiene is associated with weight loss and tissue thickness of the uterus. Due to the disturbance in the hormonal system, which is probably due to the specificity of the drug, it will also be limited due to the reduction in estradiol, which is a female hormone.
http://armaghanj.yums.ac.ir/article-1-1670-en.pdf
Liraglutide
uterine changes
estradiol hormone