fa بررسی ارتباط سنگ کلیه با کم خونی در جمعیت کوهورت بزرگسالان شهرستان فسا علوم آزمایشگاهی Clinical laboratory پژوهشي Research <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">مقدمه: کم‌خونی از شایع‌ترین مشکلات سلامت عمومی است و پیامدهای فردی و اجتماعی مهمی دارد. از سوی دیگر، سنگ کلیه به‌عنوان یکی از بیماری‌های اورولوژیک شایع مطرح است و برخی شواهد به ارتباط احتمالی آن با وضعیت خونی اشاره دارند. با این حال، شواهد در جمعیت ایرانی محدود و متناقض است</span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">.</span></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">روش ها: این مطالعه مقطعی بر روی 9121 فرد بزرگسال شرکت‌کننده در مراکز درمانی شهرستان فسا انجام شد. داده‌های دموگرافیک، سوابق پزشکی و شاخص‌های آزمایشگاهی استخراج گردید. سطح هموگلوبین به‌عنوان متغیر وابسته و وجود سنگ کلیه</span></span></span></span></b><b> </b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">به‌عنوان متغیر مستقل بررسی شد. تحلیل داده‌ها با آزمون‌های آماری مناسب و سطح معنی‌داری 0.05 انجام گرفت. نتایج به‌صورت </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">Odds Ratio (OR)</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt"> با فاصله اطمینان 95 درصد (</span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">CI95%</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">) و </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">P-value</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt"> گزارش شدند</span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">.</span></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">یافته‌ها</span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">: </span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">میان سنگ کلیه، سایر بیماری‌های مزمن و بیماری‌های اورولوژیک غیرسنگ با سطح هموگلوبین ارتباط آماری معنی‌داری مشاهده نشد (برای سنگ کلیه: </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">OR=1.13</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">؛ </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">CI95%: 0.91&ndash;1.39</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">؛ </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">P=0.19</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">). با این حال، شاخص‌های </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">WBC</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt"> و </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">RDW</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt"> در بیماران دارای سنگ کلیه نزدیک‌ترین ارتباط به سطح معنی‌داری داشتند (به‌ترتیب </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">OR&asymp;1.10</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">؛ </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">CI95%: 0.95&ndash;1.28</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">؛ </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">P=0.12</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt"> و </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">OR=1.15</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">؛ </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">CI95%: 0.98&ndash;1.34</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">؛ </span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">P=0.09</span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">).</span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt"></span></span></span></span></b></span></span></span></span></span><br> <span style="font-size:11pt"><span style="line-height:150%"><span style="direction:rtl"><span style="unicode-bidi:embed"><span style="font-family:Calibri,sans-serif"><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">نتیجه‌گیری</span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt">: </span></span></span></span></b><b><span lang="AR-SA" style="font-size:9.0pt"><span style="line-height:150%"><span 2="" style="font-family:" yagut=""><span style="letter-spacing:.2pt">مطالعه حاضر ارتباط معناداری بین سنگ کلیه و کم‌خونی نشان نداد، اما روندهای مشاهده‌شده می‌تواند بیانگر نقش احتمالی فرآیندهای التهابی و کلیوی در تغییرات سطح هموگلوبین باشد. انجام مطالعات آینده‌نگر با حجم نمونه بیشتر و بررسی متغیرهای مخدوش‌کننده مانند وضعیت تغذیه، شاخص‌های التهابی و مصرف داروها توصیه می‌شود.</span></span></span></span></b><b><span dir="LTR" style="font-size:9.0pt"><span style="line-height:150%"><span new="" roman="" style="font-family:" times=""><span style="letter-spacing:.2pt"></span></span></span></span></b></span></span></span></span></span><br> &nbsp; Anemia is one of the most common public health problems and has important individual and social consequences. On the other hand, kidney stones are considered as one of the common urological diseases and some evidence points to its possible relationship with blood status. However, the evidence in the Iranian population is limited and contradictory.<br> Methods: This cross-sectional study was conducted on 9121 adult participants in Fasa city health centers. Demographic data, medical history and laboratory indicators were extracted. Hemoglobin level was investigated as the dependent variable and the presence of kidney stones as the independent variable. Data analysis was performed with appropriate statistical tests and a significance level of 0.05. The results were reported as Odds Ratio (OR) with 95% confidence interval (CI95%) and P-value.<br> Results: No statistically significant association was observed between kidney stones, other chronic diseases, and non-stone urological diseases with hemoglobin levels (for kidney stones: OR=1.13; CI95%: 0.91&ndash;1.39; P=0.19). However, WBC and RDW indices in patients with kidney stones had the closest association to the significant level (OR&asymp;1.10; CI95%: 0.95&ndash;1.28; P=0.12 and OR=1.15; CI95%: 0.98&ndash;1.34; P=0.09, respectively).<br> Conclusion: The present study did not show a significant association between kidney stones and anemia, but the observed trends may indicate the possible role of inflammatory and renal processes in changes in hemoglobin levels. Prospective studies with a larger sample size and examining confounding variables such as nutritional status, inflammatory markers, and medication use are recommended.<br> &nbsp; کلمات کلیدی: سنگ کلیه، کم‌خونی، هموگلوبین، بیماری مزمن کلیه Kidney stones, anemia, hemoglobin, chronic kidney disease 0 0 http://armaghanj.yums.ac.ir/browse.php?a_code=A-10-3210-1&slc_lang=fa&sid=1 mohammad ghorbani محمد قربانی mohammad6067@gmail.com 100319475328460034157 100319475328460034157 Yes علوم پزشکی فسا محمدرضا رحمانیان mohammad67@gmail.com 100319475328460034158 100319475328460034158 No علوم پزشکی فسا مهدی بخشی m.bakhshii@yahoo.com 100319475328460034159 100319475328460034159 No علوم پزشکی فسا