@ARTICLE{Matin Homaee, author = {Bakhtiari, F and Matin Homaee, H and Ghazalian, F and }, title = {The Effects of 4 Weeks Aerobic Training on Oxidative and Angiogenesis Markers of Cardiac Tissue in Type 2 Diabetic Male Wistar Rats}, volume = {24}, number = {5}, abstract ={Background & aim: Type 2 diabetes exerts oxidative and anti-angiogenic effects through different pathways in the heart tissue. The aim of the present study was to determine and evaluate the effect of 4 weeks aerobic training on oxidative stress and angiogenesis in cardiac tissue of male rats with type 2 diabetes. Methods: In the present experimental study, 30 male Wistar rats were randomly divided into three equal diabetic groups with aerobic training, diabetic control group and healthy control group. Induction of type 2 diabetes was induced by intraperitoneal injection of STZ. The incremental aerobic exercise protocol consisted of 4 weeks, 5 sessions per week of running on the treadmill at a speed of 20 m/min for 60 min. ROS and NO levels were measured by spectrophotometer and colorimetric respectively. Expression of HIF-1α and VEGF genes were evaluated by Real time PCR. Data were analyzed using one-way ANOVA and Bonferroni post hoc tests. Results: the results revealed that type 2 diabetes significantly increased ROS (p<0.05) and decreased NO (p<0.05), HIF-1α (p<0.05) and VEGF (p>0.05) compared with control group. Aerobic training significantly decreased ROS (p<0.05) and NO (p<0.05) and increased HIF-1α (p<0.05) and VEGF (p<0.05) genes respectively in comparison with the control group. Also, aerobic training significantly reduced glucose (p<0.05) compared to the control group. Conclusion: Type 2 diabetes increased oxidative stress in heart tissue and disrupted the process of angiogenesis in diabetic heart. Aerobic exercise seemed to have a positive effect on the process of angiogenesis by decreasing ROS and can improve diabetic heart. }, URL = {http://armaghanj.yums.ac.ir/article-1-2579-en.html}, eprint = {http://armaghanj.yums.ac.ir/article-1-2579-en.pdf}, journal = {Armaghane Danesh}, doi = {10.52547/armaghanj.24.5.ضمیمه2.892}, year = {2019} }