TY - JOUR T1 - The Effect of Endurance Training on Expression of Specific Lipid Profile (FSP27) and Insulin Resistance in Diabetic Rats TT - اثر شدت‌های مختلف تمرین استقامتی بر بیان پروتئین ویژه بافت چربی27 (FSP27 ) احشایی و مقاومت به انسولین موش‌های صحرایی دیابتی شده JF - yums-armaghan JO - yums-armaghan VL - 23 IS - 2 UR - http://armaghanj.yums.ac.ir/article-1-2032-en.html Y1 - 2018 SP - 160 EP - 174 KW - FSP27 KW - endurance training KW - visceral fat tissue KW - insulin resistance N2 - Background & Aim:Fat-Specific Protein 27 (Protein Specialty Protein) is one of the proteins that play a role in the regulation and metabolism of lipid droplets. The aim of this study was to evaluate the effect of endurance training on expression of specific lipid profile (FSP27) and insulin resistance in STZ-diabetic rats. Methods: In this experimental study, 40 male Wistar rats were divided into five groups (diabetic group), low intensity endurance training (DLE), diabetic group, moderate intensity exercise (DME), diabetic group, and endurance training with intensity High (DHE), control group of diabetic (DC) and healthy control (HC). After diabetic administration, streptozotocin was injected with endurance training with low, moderate and high intensity for eight weeks, three sessions per week and each session for 30 minutes. Serum glucose levels were measured by glucometer, insulin with mouse specific ELISA kit, relative expression of FSP27 protein with Western Blot method and insulin resistance index. One-way analysis of variance and Tukey and James Howell post hoc tests were used to determine the difference between groups. Results: The results showed that endurance training with three severity (low, moderate and high) had a significant effect on serum glucose, insulin and insulin resistance values ​​(p = 0.001). Reductions in serum salivary and glucose levels were significant in high intensity exercise groups and moderate intensity exercises versus diabetic control and low intensity exercise (p≤0.05). Insulin resistance values ​​were significantly higher in moderate and high intensity training groups compared to low exercise group, diabetic control group and healthy control group (p≤0.05). The expression of FSP27 protein in endurance training groups with three intensities with diabetic control and healthy control was not significantly different. However, the results showed that the content of FSP27 in the training groups increased with intensity of exercise compared to the diabetic control group (the value of p was exactly noche, not approximation) Conclusion: Although, none of the endurance training interventions produced a significant difference in FSP27. Considering the tendency to increase FSP27 with increasing endurance training, it seems that endurance training with an appropriate intensity can be achieved by increasing FSP27 and subsequent reduction of the acids Free fat on the one hand and increased glucose uptake, on the other hand, increase insulin sensitivity and improve insulin resistance in diabetic rats. M3 ER -