TY - JOUR JF - yums-armaghan JO - armaghanj VL - 21 IS - 8 PY - 2016 Y1 - 2016/11/01 TI - Effect of 12 weeks aerobic exercise for along with folic acid supplementation on the levels of the ghrelin hormone amount of food intake and weight changes of female Wistar rats TT - تأثیر دوازده هفته تمرین هوازی همراه با مصرف مکمل اسید فولیک بر سطح هورمون گرلین میزان غذای مصرفی و تغییرات وزن موش‌های صحرایی ماده ویستار N2 - Background & aim: Results of numerous studies have shown that approximately 1 to 78 percent of female athletes suffer from eating disorders. On the other hand, it has been mentioned that folic acid could increase appetite. The ghrelin hormone is known as a strong stimulant for appetite. Therefore, to clarify the role of exercise and food intake of folic acid on plasma acylated ghrelin the study aim was to evaluate the effect of 12 weeks of aerobic training on ghrelin supplementation of folic acid and quantity of food intake and weight change in female rats. Methods: In the present experimental study, 24 rats were randomly divided into three groups of 8 including: control, training and training along with folic acid supplementation. The training protocol consisted of aerobic exercise running on a treadmill for 12 weeks (5 days a week). Standard meal and water were freely provided for the subjects and in the supplement group 10 mg dissolved folic acid per liter of water were used and then the food intake and body weight was measured every week. 24 hours after the last session of training and 8 hours of overnight fasting, blood and tissue samples were collected and hormones levels were measured using Eliza method. To data analyzing, one way ANOVA and Tukey post hoc test was used. Results: The results showed that 12 weeks of aerobic training with folic acid supplementation had significantly reduced serum acylated ghrelin levels (P<0.05), but no sign on stomach tissue acylated ghrelin was seen (P>0.05). The 12-week aerobic training with folic acid intake in comparison with other groups significantly increased food intake and body weight gain (p < 0.05). Conclusion: According to the acylated ghrelin reduction and lack of change in the stomach acylated ghrelin with increased food intake and body weight in rats, it seems that taking folic acid supplements inactive athletes with another strong mechanism, increasing consumption of food and influence on appetite center. SP - 746 EP - 756 AU - Parvizi, A AU - Ghasemnian, A AU - Rahmani, A AD - Department of Sport Sciences, University of Zanjan, Zanjan, Iran KW - Aerobic training KW - Folic acid KW - Acylated ghrelin KW - Weight changes UR - http://armaghanj.yums.ac.ir/article-1-1474-en.html ER -