%0 Journal Article %A Salehpoor, GH %A Kafi, SM %A Rezaei, S %A Hosseininezhad, M %A Salehi, I %T Depression and Sub-clinical Markers of Multiple Sclerosis %J Armaghane Danesh %V 19 %N 2 %U http://armaghanj.yums.ac.ir/article-1-443-en.html %R %D 2014 %K Key words: Multiple Sclerosis, Depression, Fatigue, Pain, %X Abstract Background & aim: Multiple sclerosis is a chronic neurological disease that depression has been found in more than 40% of its patients and by several sub-clinical markers associated with disease the opportunity will appearance. Aim of this present study was investigation depression and multiple sclerosis sub-clinical markers. Methods: In this analytical cross-sectional study, 162 patients with multiple sclerosis were selected by consecutive sampling and using the clinical and demographic variables inventory, Depression, Anxiety and Stress Scale, Short Form Health Survey questionnaire, Fatigue Severity Scale along with identical analog-spring balance were examined. The data were analyzed by pearson correlation coefficient, one way analysis of variance, Tukey's test and stepwise multiple regression. Results: Patients with 3 or more times the number of relapses and hospitalizations experienced, received significantly more depression scores than patients with lower frequent relapse and hospitalization. In addition, sub-clinical markers of the disease together could explain 30% of the shared variance of depression. Overall in final step limitations due to physical problems, fatigue and bodily pain could significantly predicts depression scores in patients (P %> http://armaghanj.yums.ac.ir/article-1-443-en.pdf %P 146-160 %& 146 %! %9 Research %L A-10-1-307 %+ %G eng %@ 1728-6506 %[ 2014