RT - Journal Article T1 - Effect of Hydrophilic Extract of Allium Jesdianum on Ethylene Glycol-Induced Renal Stone in Male Wistar Rats JF - yums-armaghan YR - 2012 JO - yums-armaghan VO - 16 IS - 6 UR - http://armaghanj.yums.ac.ir/article-1-291-en.html SP - 566 EP - 577 K1 - Allium Jesdianum K1 - Nephrolithiasis K1 - ethylene glycol K1 - calcium oxalate AB - Background & Aim: Considering the evidence which show the effect of herbal medicine on renal stone treatment, the aim of this study was to evaluate the efficacy of Allium Jesdianum on prevention and treatment of calcium oxalate stone in rats. Methods: In the present experimental study, forty-four male Wistar rats were randomly divided into four groups (each group 11 rats) and then studied for 30 days. The Healthy control group only received normal water and a regular diet. The negative control group received 1% ethylene glycol in water during the study. The low dose and high dose preventive groups received 750 mg/kg and 1500 mg/kg of Allium Jesdianum with 1% ethylene glycol every day. The 24-hour urine samples of rats were collected on days 1, 15 and 30 of the study. Then, under anesthesia, blood samples were taken directly from the heart. All rats were then killed and pathology of kidneys was checked for crystals of calcium oxalates in renal tubules. Data analysis was done by the SPSS software using One-way ANOVA. Results: The number of calcium oxalate crystals in the negative control group (18.7 ±26.1), the low dose preventive group (5.3±8.2) and high dose preventive group (80.6±82.8) in comparison to the healthy control group were increased and this difference in the high dose preventive group and healthy control group was significant (p LA eng UL http://armaghanj.yums.ac.ir/article-1-291-en.html M3 ER -