:: Volume 20, Issue 10 (1-2016) ::
__Armaghane Danesh__ 2016, 20(10): 858-872 Back to browse issues page
Study Of Hepato Protective Effects Of Avicenniamarina Hydro Ethanolic Leaves Extract In Male Rats Induced With Carbone Tetrachloride
M Gholami1, N Mirazi 2
1- Department of Biology, Faculty of basic sciences, BU-AliSinaUniversity, Hamedan, Iran.
2- Department of Biology, Faculty of basic sciences, BU-AliSinaUniversity, Hamedan, Iran. , mirazi205@gmail.com
Abstract:   (3106 Views)

Background & aim: The inflammation and necrosis in hepatocyte causes disorders in liver functions when induced with toxins. Medicinal plants have hepatoprotectivity effects and can inhibit the heptotoxicity progressing in the liver. In this study the hepatoprotectivity effect of Avicenniamarina hydro ethanolic leaves extract (AME) were investigated in malerats induced with carbone tetrachloride.

Methods: In this study, 42 male rats with 220-250 gr body weight were divided randomly in 6 groups (n=7): control, sham(taking olive oil, 2ml/kg/day, i.p),witness group(taking carbontetrachloride 1:1 with olive oil,2ml/kg, single dose, i.p) and treatedgroups: (1,2 and3inducedbycarbontetrachloride 1:1 with olive oil, 2ml/kg ,andafter2 hours 200, 400 and 800mg/kg  AME /dayfor4 days,i.p).Thecontrolgroup (taking normal saline, 0.5ml/day,i.p). Aftertheexaminationthebloodsampleswerecollectedfromheartdirectly and albumin, total protein, totalbilirobin and liver enzymes wereanalyzed.

Results: Carbon tetrachloride reduced serum albumin and total protein and increased total bilirubin in groups induced with ccl4 significantly (P<0.001). In treated groups serum albumin and total protein increased and total bilirubin decreased compared with witness groups significantly (P <0.05). CCl4 increased ALT, AST and ALP significantly and in treated group reduced significantly(P<0.001).

Conclusion: The Avicennia marina hydoethanolic extract has antioxidant and flavonoids compounds. These materials could be able to protect the tissues, such as liver tissue, from toxic agentssignificantly.

Keywords: Avicennia marina, Albumin, Total protein, Total Bilirubin, carbon tetrachloride, rat
Full-Text [PDF 3551 kb]   (1778 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/07/6 | Accepted: 2015/11/9 | Published: 2015/12/9

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Volume 20, Issue 10 (1-2016) Back to browse issues page