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The Effect of Frankincense Extract on Accumulation of Fatty Streaks in Coronary Arteries of High-Cholesterol Fed Male Rabbits
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GH Dashti   , E Esfandiari , M Nematbagksh , MH Sanei , S Afsharipoor , A Farzan , M Jaafari Barmak |
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Abstract: (4835 Views) |
| Introduction & Objective: Coronary arteries diseases and
atherosclerosis are the most prevalent mortality and morbidity in
the world. This study was designed with goal of effect of
frankincense extract on accumulation of fatty streaks in coronary
arteries of high- cholesterol fed male rabbits.
Materials & Methods: Twenty white male rabbits (wt = 1.780 kg)
were weighed and blood samples were taken for analysis of serum
cholesterol, TG, LDL, HDL, VLDL. After taking the sample rabbits
were randomly divided into two groups. For 40 days group 1
(n=10) was given high cholesterol (1%) diet with frankincense
extract (500 mg/kg) and group 2 (n=10) were fed with high
cholesterol with distilled water. Then, both groups weighted and
blood samples were taken. Finally, the animals were sacrificed and
their coronary arteries were dissected. Pathological smear were
prepared and stained with H&E. The plaque of atherosclerotic was
evaluated by light microscope.
Results: Results of this study indicate that rabbits which received
frankincense extract showed significant difference in cholesterol,
TG, LDL, HDL, VLDL in compare with other group (p < 0.05). Also,
our results showed a significant difference in mean of pathological
scoring of four branch of coronary arteries (p < 0.05).
Conclusion: Significant differences in all of parameters such as
weight, serum cholesterol, TG, HDL, LDL, VLDL might be related
to effect of frankincense extract on lipid metabolism. Pathological
results showed that frankincense extract could decrease
accumulation of fatty streaks in all branches of coronary arteries.
Thus frankincense extract can be for preventing of used
cardiovascular diseases, atherosclerosis and for treatment of
lipidemia |
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| Keywords: Frankincense, Cholesterol, Coronary artery, Fatty streak |
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Full-Text [PDF 215 kb]
(2551 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/06/13 | Accepted: 2015/06/13 | Published: 2015/06/13
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