|
Effects of sinapic acid on memory retention in adult male Wistar rats
|
Mahshid Nosrat1   , Akram Eidi 1, Ali Haeri Rohani1 |
| 1- Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran |
|
|
Abstract: (4325 Views) |
| Background & aim: Sinapic acid is a phenylpropanoid compound and is widely distributed in the plant kingdom and is obtained from various sources such as rye, fruits and vegetables. This study concerned effects of sinapic acid on memory retention of passive avoidance learning in adult male Wistar rats.
Methods: In this experimental study, 64 male Wistar rats were randomly allocated into 8 groups. Control animals were intact. Sham group received vehicle of sinapic acid (Tween 80, 10%). The experimental rats administrated with sinapic acid at doses 0.01, 0.03, 0.05, 0.1, 1 and 10 g/rat respectively. Sinapic acid and Tween 80 were injected intracerebroventricular and post-training. Twenty-four hours after training, memory retention was evaluated with passive avoidance learning. The step through latency and time in dark compartment was measured. The data were expressed as mean values ± SEM and tested, using analysis of one-way ANOVA test.
Results: Our results showed that post-training administration of sinapic acid at doses 0.05, 0.1, 1, 10 and 10 g/rat increased significantly the time of step-through latency and decreased significantly the time of dark compartment as compared to sham group (p<0.05).
Conclusion: Sinapic acid potentiated significantly memory retention process. |
|
| Keywords: Sinapic acid, Memory, Learning, Rat |
|
|
Full-Text [PDF 203 kb]
(1245 Downloads)
|
Type of Study: Research |
Subject:
Special
Received: 2015/02/27 | Accepted: 2015/02/27 | Published: 2015/02/27
|
|
|
|
|
|
|
| Add your comments about this article |
|
|
|
