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Effect of Ocimum Basilicum Hydro Alcoholic Extract Against Pentylenetetrazole-Induced Seizure in Mice
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M Modaresi   1, A Pouriyanzadeh |
| 1- , mehrdad_modaresi@hotmail.com |
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Abstract: (6029 Views) |
| Abstract
Background & aim: Epilepsy is one of the most common neurological disorders has always been considered. Despite the using of various drugs a number of patients are still drug-resistant. Osmium basilica was used in traditional medicine in the treatment of epilepsy and antiepileptic effects of this drug have been reported. The aim of this study was to evaluate the anticonvulsant effects of hydroalcoholic extract of Osmium basilicum in animal seizure models in mice.
Methods: In this experimental study, 48 mature female mice were divided into 6 groups. The Hydro alcoholic extract of basil was prepared and then diluted with saline. Experimental groups included control, placebo and four treatments. 65 min before the injection of the Pentylenetetrazole all groups were received 100, 250, 300 and 350 mg/kg of extract intraperitoneally. The factors of seizure symptoms and signs were assessed. Data Tukey, Duncan were analyzed by ANOVA.
Results: treated Group with 100 mg/kg of extract showed the highest seizure. Two groups treated with 100 and 250 mg/kg compared with the other groups had the highest and lowest incidence of myoclonic contractions respectively. 65 min before PTZ injection, the group treated with 250 mg/kg of extract showed a number of seizures and the mortality and morbidity rate increased and reduced significantly (p<0.05).
Conclusion: The results can be obtained at a dose of hydro alcoholic 250 mg/kg effective as medication in preventing seizures in animal models introduced.
The hydroalcoholic extract of Osmium basilica at dose of 250 mg kg proposed as an effective medication to prevent seizures in animal models.
Key words: Epilepsy, Seizure, Ocimum basilicum , Pentylenetetrazole |
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| Keywords: Key words: Epilepsy, Seizure, Ocimum basilicum, Pentylenetetrazole |
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Full-Text [PDF 677 kb]
(1857 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/05/4 | Accepted: 2015/05/4 | Published: 2015/05/4
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