[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Indexing & Abstracting::
Publication Ethics::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing & Abstracting
DOAJ
GOOGLE SCHOLAR
..
:: Volume 25, Issue 2 (4-2020) ::
__Armaghane Danesh__ 2020, 25(2): 225-239 Back to browse issues page
The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis
A Karimpour1 , AM Mazare1 , SH Hadianpour1 , M Molla Agha Zarandi2 , M Hosseini1 , B Alipoor 3
1- Student Research Committee, Yasuj University of Medical Sciences, Yasuj, Iran
2- Ministry of Health and Medical, Tehran, Iran
3- Department of Laboratory Sciences, Yasuj University of Medical Sciences, Yasuj, Iran. , behnam.alipour@yums.ac.ir
Abstract:   (3318 Views)
Background & aim: Several studies have examined the link between existing polymorphisms in the coding miR-146a and miR-27a genes with type 2 diabetes, although the results presented were inconsistent. Accordingly, in the present meta-analysis study, in order to obtain a more accurate estimate, the relationship between MiR146a-rs290164 G> C and miR-27a rs8955819 T> C with T2D was investigated.
 
Methods: To conduct this review study, studies were selected by searching the electronic databases of PubMed, Google Scholar, Scopus, and Science direct until June 6, 2017. A total of 2,069 diabetics and 1,907 healthy subjects entered the meta-analysis to assess the association of rs2910164 and 1090 diabetics and 966 controls to assess the association of rs895819 with type 2 diabetes with an OR chance ratio of 95% confidence interval.
 
Results: In the present study, the relationship between polymorphism miR-146a rs2910164 and T2D in five different genetic models including allelic, defeated, dominant, over-dominant and co-dominant models was investigated. No significant relationship was observed between miR-146a rs2910164 and miR-27a rs895819 variants with T2D (P> 0.05). There was also no evidence of diffusion bias in the various genetic models studied was observed (P Egger, s test> 0.05).
 
Conclusion: The present meta-analysis indicated that there was no significant relationship between the variants studied with T2D. To confirm these results, more research is needed in populations with higher sample size and greater geographical diversity.

 
 
Keywords: Rs2910164, Rs895819, Type 2 Diabetes, Meta-Analysis
Full-Text [PDF 1549 kb]   (517 Downloads)    
Type of Study: Review Article | Subject: Biochemistry
Received: 2019/06/20 | Accepted: 2020/01/14 | Published: 2020/05/4
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Karimpour A, Mazare A, Hadianpour S, Molla Agha Zarandi M, Hosseini M, Alipoor B. The Association of MiR-146a and MiR-27a Gene Variants with Type 2 Diabetes: A Meta-Analysis. armaghanj 2020; 25 (2) :225-239
URL: http://armaghanj.yums.ac.ir/article-1-2557-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 25, Issue 2 (4-2020) Back to browse issues page
ارمغان دانش Armaghane Danesh
Persian site map - English site map - Created in 0.05 seconds with 39 queries by YEKTAWEB 4645