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:: Volume 23, Issue 4 (10-2018) ::
__Armaghane Danesh__ 2018, 23(4): 499-515 Back to browse issues page
Anti- bacterial effects of pigmented Serratia marcescens on the multi-drug resistance Klebsiella isolated from burn wound
Elham Moazamian Dr 1, Amir Emami Dr
1- , elhammoazamian@gmail.com
Abstract:   (179 Views)
Background and aims: With respect to the increasing rates of antibiotic resistance in pathogenic bacteria, identification of new antimicrobial compounds is necessary. Bacterial pigments as biological active compounds are good candidates for identification of novel antimicrobial agents. Bacteria, which may provide new and valuable metabolites, have been the focus of many studies recently.
Methods: In this research, a total of 37 pigmented bacterial strains were obtained from soil samples of different regions of Fars province. These strains contained a wide variety of pigmentation including: red, yellow and green. Strains with different pigmentation were selected for further studies. Pigments were extracted by methanol-water or methanol for secreted and non-secreted pigments, respectively. In order to evaluate the antibacterial activity of pigments, disc diffusion and macrodilution dilution assay were used on MDR Klesiella isolated from clinical samples. Finally, microorganism with anti-bacterial pigment was identified by molecular method. 
Results: Base on the morphology of isolated pigment colonies in different environments and carrying out biochemical tests, the presence of bacteria such as, Pseudomonas aeroginosa, Serratia marcescens, Enterobacter sakazakii, Flavobacter mizutaii, Micrococcus luteus and Staphylococcus aureus has been proven.
Total frequency of Klebsiella isolates was 8.5%. Of the 17 isolated isolates, 12 isolates were completely resistant to all antibiotics, and six isolates were sensitive to the imipenem antibiotic.
All of Klebsiella isolates were multi drug resistance. A Red pigment from Serratia marcessence was the most potent and showed inhibitory effects on MDR Klebsiella. None of
Conclusion: Isolated microorganisms from environmental resources contain a very diverse collection of pigments, where different pigment structures with different antimicrobial properties can be searched. The present study show that bacterial pigments can be effective against MDR Klebsiella isolates.
Keywords: Burn wound samples, Bacterial pigments, antibiotic resistance, Klebsiella
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Type of Study: Research | Subject: Microbiology
Received: 2018/03/9 | Accepted: 2018/08/17 | Published: 2018/10/2
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Moazamian E, Emami A. Anti- bacterial effects of pigmented Serratia marcescens on the multi-drug resistance Klebsiella isolated from burn wound. Armaghane danesh. 2018; 23 (4) :499-515
URL: http://armaghanj.yums.ac.ir/article-1-2132-en.html

Volume 23, Issue 4 (10-2018) Back to browse issues page
ارمغان دانش Armaghane danesh
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