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Effects of Metformin and Ginger Rhizome Extract on the Pituitary - Gonad Function in Adult Female Rats With Polycystic Ovary Syndrome
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M Foroozandeh1   , SE Hosseini 2 |
1- Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran,2Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran.
2- Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran,2Department of Biology, Shiraz Branch,Islamic Azad University, Shiraz ,Iran. , ebrahim.hossini@yahoo.com |
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Abstract: (10712 Views) |
Abstract:
Background & aim: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of infertility in women. Due to the prevalence of PCOS in worldwide, the aim of this study is defined to compare the impact of metformin with ginger on pituitary-gonad function in PCOS adult female rats .
Methods: In this experimental study72 adult female rats were used. The rats were divided in a control of PCOS and 7 experimental groups of PCOS receiving metformin alone at 150 mg / kg, ginger with 100, 200 and 300 mg/kg doses, and ginger with doses of 100, 200 and 300 mg/kg with metformin at a dose of 150 mg / kg. All prescriptions were performed for 28 days in a gavage. Blood samples were taken from animals to measure the FSH, LH, estrogen, progesterone and testosterone hormones, their ovaries were removed and follicular tissue sections were counted. Statistical data were analyzed using ANOVA and nhk; k tests.
Results: Letrozole induced PCOS increased follicles of atritic, testosterone, estrogen and other follicles and FSH levels at the level of P<0.01, and metformin and ginger alone and with each other reduced the number of atritic follicles and increased other follicles and FSH levels at p <0.01. Also, consumption of metformin and ginger significantly decreased testosterone and estrogen levels at the level of p <0.01 compared to the control group.
Conclusion: Administration of metformin and extract of rhizome ginger alone or with each other increases FSH and primary follicles, primary, secondary, graviflower, yellow corpuscles, and reduction of atritic follicles in animals with polycystic otitis media due to letrozole administration, as well as metformin and ginger extract. There is no significant effect on the level of estrogen and testosterone hormones in these animals, while the simultaneous administration of both decreases estrogen and testosterone levels in animals with polycystic ovarian dysfunction.
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| Keywords: polycystic ovary, metformin, ginger rhizome, progesterone, testosterone, estrogen, FSH, LH |
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Full-Text [PDF 184 kb]
(2036 Downloads)
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Type of Study: Research |
Subject:
Physiology
Received: 2017/06/16 | Accepted: 2017/08/4 | Published: 2017/08/10
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