:: Volume 22, Number 3 (6-2017) ::
__Armaghane Danesh__ 2017, 22(3): 337-349 Back to browse issues page
Comparing effects of metformin and ginger rhizome extract on the pituitary - gonad function in adult female rats with polycystic ovary syndrome
Mahbobeh Foroozandeh1, syed Ebrahim Hosseini 2
1- MSc Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, I.R.Iran
2- Associate Professor Department of Biology, Shiraz Branch, Islamic Azad University, Shiraz, I.R.Iran , ebrahim.hossini@yahoo.com
Abstract:   (677 Views)

Background & aim: Polycystic Ovary Syndrome (PCOS) is one of the most common causes of infertility in women. Due to the prevalence of PCOS in worldwide, this study aimed to compare the effect of metformin with ginger on pituitary-gonad function in PCOS adult female rats was performed. Methods: In this experimental study, 72 adult female rats divided to control, sham PCOS and 7 experimental groups PCOS receiving metformin at 500mg/kg, the ginger at doses 100, 200 & 300mg/kg and ginger at doses 100, 200 & 300mg /kg with metformin at 500 mg/kg were used. All injections by gavage and for 28 days were conducted. After phlebotomizing the animals, to measure hormones FSH, LH and estrogen, progesterone and testosterone, their ovaries removed and after preparing tissue sections, follicles were counted. Data obtained by 18-SPSS software and ANOVA and Duncan were analyzed, then the significant difference of data at P> 0.05was considered. Results: The results showed that letrozole by creating PCOS causes to increase atretic follicles, testosterone, estrogen and reduce other follicles and FSH at P<0.01, and metformin and Ginger alone and together cause to reduce atretic follicles, testosterone, estrogen and increase other follicles and FSH at P<0.01. Conclusion: The results showed that metformin and Ginger alone or together cause to improve PCOS, and these improvements in both groups receiving simultaneous ginger with metformin can be seen more.

Keywords: Keyword: polycystic ovary, metformin, ginger rhizome, progesterone, testosterone, estrogen, FSH, LH, Rat
Full-Text [PDF 184 kb]   (190 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2017/06/16 | Accepted: 2017/08/4 | Published: 2017/08/10



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Volume 22, Number 3 (6-2017) Back to browse issues page