:: Volume 22, Issue 6 (2-2018) ::
__Armaghane Danesh__ 2018, 22(6): 702-713 Back to browse issues page
Effects of combined exercise training with aerobic dominant and coenzyme Q10 supplementation on some of the inflammatory factors in patient with multiple sclerosis
Javad Nakhzari Khodakheir Mr 1, Amir Hossein Haghighi Mr2, Mohammad Reza Hamedinia Mr3, Karim Nikkhah Mr4
1- PhD Candidate Hakim Sabzevari University , elia_3812@yahoo.com
2- Associate professor Hakim Sabzevari University
3- Full professor Hakim Sabzevari University
4- Associate professor Mashhad University of Medical Sciences
Abstract:   (516 Views)

The effects of combined exercise training with aerobic dominant and coenzyme Q10 supplementation on serum levels of IL-10 and TNF-α in patient with multiple sclerosis


Introduction: Multiple sclerosis (MS) is an autoimmune, inflammatory, chronic and progressive disease of central nervous system in which myelin sheath and axons of nerve cells in the brain and spinal cord destroyed by immune system. The change in concentration of cytokines is the major physiological symptom of the disease, whereas physical activity and exercise is an important non-pharmacological method in maintain homeostasis of physiological symptom in MS disease. The aim of this study was to determine the effect of eight weeks of exercise training combined with Q10 supplementation on serum TNF-α and IL-10 in patients with multiple sclerosis.

Materials and Methods: In the present experimental research, twenty eight MS patients (EDSS=3-5) Were selected by using available sampling method and randomly divided into three experimental groups (combined exercise training + Q10 supplementation, combined exercise training + placebo & Q10 supplementation) and one control group (5 female and 2 male in each group). Two groups of three experimental groups performed a combined exercise program include two sessions of endurance training (%50-60 max HR at beginning to end)  and one session of resistance training (%50-60 1RM at beginning to end) three sessions per week. 200 mg of CoQ10 supplement was prescription per day. Blood samples (after 10 hours fasting) were collected 24 hours before the first and 24 hours after the last session of exercise for evaluation of serum levels of IL-10 and TNF-α. Data were analyzed with Shapiro - Wilk and analysis of covariance at a significance level of P<0.05.

Results: The results showed no significant changes in serum levels of IL-10 and TNF-α in the three experimental groups compared to the control group (P≥0/05).

Conclusion: Combined exercise training with coenzyme Q10 supplementation cannot lead to changes in concentration of IL-10 and TNF-α in patient with MS. Therefore, it is necessary to change the duration and severity of this type of training as well as dose of supplementation.

Keywords: multiple sclerosis, combined exercise training, Coenzyme Q10, IL-10, TNF-α
Full-Text [PDF 769 kb]   (39 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2017/03/6 | Accepted: 2017/08/4 | Published: 2018/01/22

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Volume 22, Issue 6 (2-2018) Back to browse issues page