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:: Volume 22, Number 2 (5-2017) ::
__Armaghane Danesh__ 2017, 22(2): 189-204 Back to browse issues page
Therapeutic effect of Aerobic Training on Cross-Linked Telopeptides of Type I Collagen (CTX) as Bone Reasorption Indicative in Obese Male with Mild to Moderate Asthma
H Ghasemalipour1, M Eizadi 2, MH Dadgan1, N Shakeri3
1- Department of Physical Education and Sport Science, South Tehran Branch, Islamic Azad University, Tehran, Iran,
2- Department of Exercise Physiology, Saveh Branch, Islamic Azad University, Saveh, Iran, , izadimojtaba2006@yahoo.com
3- Department of Exercise Physiology, Science and Research Branch, Islamic Azad University, Tehran, Iran
Abstract:   (366 Views)
Background & aim: Long-term usage of inhaled corticosteroids is associated with osteoporosis in asthma patients. The purpose of this study was to determine the effect of long-term aerobic exercise on C-type collagen type T-terminal (CTX) as an indicator of bone resorption and serum calcium levels in asthmatic patients treated with inhaled corticosteroids.
Methods: For this purpose, 24 obese asthma patients treated with inhaled corticosteroids with a mean age of 38 ± 7 years and body mass index of 31.5 ± 3.15 kg / m2 were randomly divided into experimental(Without exercise) and aerobic training groups. The experimental group participated in an aerobic exercise program for 3 months in 3 sessions ranging from 45 to 60 minutes in the range of 55-75% of maximum heart rate weekly. Fasting samples were taken in both groups before and after intervention for measuring CTX and calcium levels. In order to compare the data in pre-test between two bgroups, independent t-test was used for two groups. t-test was used for determining the intra-group variation in the t test for significance level of t test p <0.05.
Results:  Aerobic intervention led to a significant reduction in weight, body mass index and body fat percentage in the experimental group (p <0.05) but CTX levels decreased after aerobic training compared to baseline levels (p = 0.002). Aerobic exercises also led to a significant increase in serum calcium (p <0.001), but this variable did not change in the control group.
Conclusion: A long-term aerobic intervention can induce favorable effect on bone turn over by improved bone resorption indicatives in asthma patients. Based on this finding, regular aerobic training is purposed to prevent and decrease osteoporosis intensity in corticosteroid-treated asthmatic patients.
Keywords: Aerobic training, Asthma, Osteoporosis, Cross-linked telopeptides of type I collagen
Full-Text [PDF 218 kb]   (123 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2017/01/26 | Accepted: 2017/06/9 | Published: 2017/06/13
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Ghasemalipour H, Eizadi M, Dadgan M, Shakeri N. Therapeutic effect of Aerobic Training on Cross-Linked Telopeptides of Type I Collagen (CTX) as Bone Reasorption Indicative in Obese Male with Mild to Moderate Asthma. Armaghane danesh. 2017; 22 (2) :189-204
URL: http://armaghanj.yums.ac.ir/article-1-1685-en.html
Volume 22, Number 2 (5-2017) Back to browse issues page
ارمغان دانش Armaghane danesh
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