:: Volume 22, Number 3 (6-2017) ::
__Armaghane Danesh__ 2017, 22(3): 325-336 Back to browse issues page
Study of hydroethanolic extract of Tragopogon pratensis L. leaves on T3, T4 and TSH serum levels in male rats induced with lead acetate
Salimeh Kiani1, Hossein Vazini 2, Naser Mirazi3
1- MSc in physiology Islamic Azad University, Hamedan Branch, Hamedan
2- Assistant professor Islamic Azad University, Hamedan Branch, Hamedan , hossein_vazini@yahoo.com
3- Associated professor Bu-Ali Sina University
Abstract:   (452 Views)

Background:  Pituitary and thyroid hormones have important roles on homeostasis control. The aim of this study was to investigate  the effect of Tragopogon pratensis L. hydroethanolic extract (TPE) on serum levels of  thyroid hormones in male rats induced with lead acetate.

Methods: In this study, 36 male Wistar rats (weighing 220-250 gr) divided in 6 groups (n=6): control, lead acetate (in tap water, 500ppm), treatment groups : (Lead acetate 500 ppm, and 200mg/kg, 400mg/kg and 800mg/kg TPE), and positive control group ( 400mg/kg TPE). All data were expressed by mean±SEM and analyzed by ANOVA and Tukey's test. The statistical differences was significant by P<0.05.

Results: Lead acetate significantly (P<0.001) decreased T3,T4,TSH serum levels. Tragopogon pratensis L. extract increased thyroid hormones in rats induced with lead acetate. It  seems that the Tragopogon pratensis L. extract can  protect thyroid gland against oxidative stress caused by lead acetate.

Conclusion: The results of this study showed that lead acetate have toxic effects on thyroid hormones and Tragopogon pratensis L. hydroalcoholic extract may have protective role on thyroid function.

Keywords: Lead acetate, Thyroid Hormones, rat, Tragopogon pratensis
Full-Text [PDF 257 kb]   (53 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2016/11/29 | Accepted: 2017/07/14 | Published: 2017/07/25

XML   Persian Abstract   Print

Volume 22, Number 3 (6-2017) Back to browse issues page