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Frequency of EBV Infection in HIV Positives Patients
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Alireza Abdollahi   1, elnaz, Irandoust2 , Mernaz Asoulinejad3 , Mona Marzban4 |
1- 1Department of Pathology, Imam Khomeini Hospital Complex,Tehran, Iran , dr_p_abdollahi@yahoo.com
2- Department of Pathology, Imam Khomeini Hospital Complex, Tehran, Iran
3- Department of Infectious and Tropical Disease, Imam Khomeini Hospital Complex, Tehran, Iran
4- Department of Virology, Tehran University Medical of Sciences, Tehran, Iran |
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Abstract: (8353 Views) |
| Background and aim: An opportunist infection in patients diagnosed with human immunodeficiency virus (HIV) is the Epstein-Barr virus (EBV) which causes serious complications. This study is conducted to examine the frequency of EBV in HIV/AIDS sufferers and compare it with non-sufferers and examine its correlation with the number of CD4+ lymphocytes.
Methods: In a case-control, prospective study, two 114-member groups (patients with and without human immunodeficiency virus) of equal sex and age – one group suffering from HIV – were assessed for the presence of IgG antibody against EBV capsid virus and the number of CD4+ lymphocytes and the results were analyzed based on the objectives of the study.
Results: A total of 103 (90.4%) of HIV-positives and 37 (32.5%) of control group were tested positive for EBV-VCA IgG (p value = 0.001). The amount of antibody and the number of CD4+ lymphocytes were in a meaningful and reverse relationship (p value = 0.0003). There was no meaningless difference between the presence of EBV-VCA IgG antibody and the age and sex of patients, transmission of virus and receiving HAART anti-virus treatment (p value>0.05)
Conclusion: Due to complications of acute EBV virus and its high frequency in HIV patients, these patients are strongly recommended to be examined for EBV infection after diagnosis in a bid to prevent more mortality and morbidity. Preventive actions and periodical checkups must be done for EBV-positives. |
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| Keywords: EBV, CD4+ Lymphocyte, HIV |
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Full-Text [PDF 346 kb]
(6178 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/03/16 | Accepted: 2015/03/16 | Published: 2015/03/16
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