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:: Volume 22, Issue 5 (12-2017) ::
__Armaghane Danesh__ 2017, 22(5): 608-622 Back to browse issues page
Effect of three months of treadmill endurance training on p53 and cytochrome-c gene expression in male rat soleus muscle
Abstract:   (1312 Views)

Aim and Background: Apoptosis in skeletal muscle plays an important role in disease-related tissue dysfunction such as muscle atrophy. Current evidence suggests that exercise trainings may alter apoptosis-related signaling and enzymes in skeletal muscle. Therefore, the purpose of this study was investigating the effect of three months of treadmill endurance training on p53 and cytochrome-c gene expression in male rat soleus muscle.

Materials and Methods: This study was conducted as a two-group experimental design and sixteen 3-month-old male rats were selected and randomly divided into two groups of endurance training (n=8) and control (n=8). Rats in trained group participated in the endurance training program for three months (75-80% AWT IMAGE). 48 hours after the last training session, the soleus muscle of rats were extracted and p53 and cytochrome-c mRNA evaluated by Real Time-PCR. Independent t-test was applied for statistical analysis of the data (P<0.05).

Results: There was no significant difference between endurance training and control group with regard to the p53 gene expression (P=0.67). However, cytochrome-c gene expression of trained group was significantly lower than the control group (64.84%, P=0.01).

Conclusion: In general, it seems that three months of endurance training was effective in decreasing of cytochrome-c gene expression and mitochondrial apoptotic in soleus muscle. However, more researches are needed to identify effects of exercise trainings on indices of apoptosis and skeletal muscle atrophy.

Keywords: Endurance training, p53 gene, Cytochrome-c gene, Soleus muscle
Full-Text [PDF 569 kb]   (368 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2016/11/8 | Accepted: 2017/09/19 | Published: 2017/12/4
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Effect of three months of treadmill endurance training on p53 and cytochrome-c gene expression in male rat soleus muscle. Armaghane danesh. 2017; 22 (5) :608-622
URL: http://armaghanj.yums.ac.ir/article-1-1571-en.html


Volume 22, Issue 5 (12-2017) Back to browse issues page
ارمغان دانش Armaghane danesh
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