[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 21, Issue 9 (12-2016) ::
__Armaghane Danesh__ 2016, 21(9): 873-886 Back to browse issues page
The impact of high intensity aerobic interval training (HIIT) and flaxseed oil on ICAM-1 gene expression in heart tissue in male Wistar rats
Y Khademi1, MA Azarbayejani 2, SA Hossini3
1- Department of Physical Education, Islamic Azad University Central Tehran Branch, Tehran, Iran
2- Department of Physical Education, Islamic Azad University Central Tehran Branch, Tehran, Iran , ali.azarbayjani@gmail.com
3- Department of Physical Education, Islamic Azad University Central Marvdasht Branch, Shiraz, Iran.
Abstract:   (3939 Views)

Abstract

Background: The prevalence of cardiovascular disease may be due to inflammation and systemic inflammation plays an important role in the development and progression of atherosclerosis. ICAM-1 is one of the important factors in the pathogenesis of atherosclerosis is an inflammatory effect of physical activity and plant protection products on the response it is not well known.

Methods

 Thirty Wistar rats were selected as sample. Rats were randomly divided into six groups of five, including control, exercise, extracts dose of 10 mg / kg, extract dose 30 mg / kg, a dose of extract practice mg / kg 10, and extracts Practice dose of 30 mg / kg, respectively. Training groups, five sessions per week for 10 weeks, intense interval training involves running on a treadmill with an intensity of 90 to 95 percent of VO2max for rodents, at specified hours during the day. After the rats were sacrificed and the heart tissue, and to measure gene expression of ICAM-1 and LFA-1 were used.

Result

Data analysis showed that the expression of ICAM-1 has been reduced in training supplement groups The expression of intercellular adhesion molecule receptor (ITG) has decreased in the exercise and supplement group.

Conclusion: The results of this study show that both exercise and extract significant effect on gene expression of ICAM-1. And decreased expression of ICAM-1 was also flax oil ICAM-1 gene expression was also reduced. The findings of this study showed that the combination of training and flax oil reduces the expression of ICAM-1 compared to the control group. So it is likely that this method can be used as a way to prevent cardiovascular disease.

Keywords: cardiovascular diseases, inflammation, atherosclerosis
Full-Text [PDF 224 kb]   (1675 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2016/09/28 | Accepted: 2016/12/5 | Published: 2016/12/17
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Khademi Y, Azarbayejani M, Hossini S. The impact of high intensity aerobic interval training (HIIT) and flaxseed oil on ICAM-1 gene expression in heart tissue in male Wistar rats. Armaghane danesh. 2016; 21 (9) :873-886
URL: http://armaghanj.yums.ac.ir/article-1-1526-en.html


Volume 21, Issue 9 (12-2016) Back to browse issues page
ارمغان دانش Armaghane danesh
Persian site map - English site map - Created in 0.06 seconds with 31 queries by YEKTAWEB 4144