Background & aim: The inflammation and necrosis in hepatocyte causes disorders in liver functions when induced with toxins. Medicinal plants have hepatoprotectivity effects and can inhibit the heptotoxicity progressing in the liver. In this study the hepatoprotectivity effect of Avicenniamarina hydro ethanolic leaves extract (AME) were investigated in malerats induced with carbone tetrachloride.

Methods: In this study, 42 male rats with 220-250 gr body weight were divided randomly in 6 groups (n=7): control, sham(taking olive oil, 2ml/kg/day, i.p),witness group(taking carbontetrachloride 1:1 with olive oil,2ml/kg, single dose, i.p) and treatedgroups: (1,2 and3inducedbycarbontetrachloride 1:1 with olive oil, 2ml/kg ,andafter2 hours 200, 400 and 800mg/kg  AME /dayfor4 days,i.p).Thecontrolgroup (taking normal saline, 0.5ml/day,i.p). Aftertheexaminationthebloodsampleswerecollectedfromheartdirectly and albumin, total protein, totalbilirobin and liver enzymes wereanalyzed.

Results: Carbon tetrachloride reduced serum albumin and total protein and increased total bilirubin in groups induced with ccl₄ significantly (P<0.001). In treated groups serum albumin and total protein increased and total bilirubin decreased compared with witness groups significantly (P <0.05). CCl₄ increased ALT, AST and ALP significantly and in treated group reduced significantly(P<0.001).

Conclusion: The Avicennia marina hydoethanolic extract has antioxidant and flavonoids compounds. These materials could be able to protect the tissues, such as liver tissue, from toxic agentssignificantly.