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:: Volume 24, Issue 6 (12-2019) ::
__Armaghane Danesh__ 2019, 24(6): 1054-1072 Back to browse issues page
The Effect of Eight Weeks of Increased Aerobic Exercise with Zinc Supplementation on Muscle Superoxide Dismutase Activity and Serum Leptin Levels and Weight Changes in Adult Wistar Rats
AA Qasemnia 1, Z Zighami2 , S Hadi2
1- Department of Sport Sciences, Zanjan University, Zanjan, Iran , ghasemnian@znu.ac.ir
2- Department of Sport Sciences, Zanjan University, Zanjan, Iran
Abstract:   (965 Views)
Background & aim: Intense and prolonged exercise and physical activity are the factors that can disrupt the balance of free radical production, antioxidant systems of the body and decreased leptin levels. It has also been suggested that zinc acts as a mediator in leptin production while affecting superoxide dismutase activation and food intake. The purpose of the present study was to determine and evaluate the effect of 8 weeks of incremental aerobic training with zinc supplementation on muscle superoxide dismutase activity, serum leptin level and weight changes in male Wistar rats.
 
Methods: In the present experimental study, 32 male Wistar rats were randomly divided into 4 equal groups (control, exercise, exercise + zinc and zinc). The training protocol consisted of incremental aerobic exercise on the treadmill for 8 weeks (5 days a week). In the zinc supplement group, 227 mg of zinc sulfate was dissolved in 100 ml of edible water and made available to the animals. 48 hours after the last training session, blood and tissue samples were collected and leptin concentration and the amount of superoxide dismutase activity was measured by ELISA and spectrophotometrically respectively. Data were analyzed using one-way ANOVA and Pearson correlation tests.
 
Results: no significant difference was observed after eight weeks of training with zinc supplementation in skeletal muscle superoxide dismutase activity among groups (p<0.05), but serum leptin and weight changes in the groups Zinc supplementation and exercise group consumed significantly less zinc supplementation than the control group (p<0.05) In the control group (P=0.04, R=0.71) and in the exercise group (P=0.03, R=0.75), there was an inverse correlation was observed between serum leptin level and muscle superoxide dismutase activity.
 
Conclusion: according to the results of the present study, it was concluded that zinc supplementation has been shown to control weight, decrease leptin and reverse the correlation between serum leptin and superoxide dismutase activity.


 
Keywords: aerobic exercise, Zinc supplementation, Superoxide dismutase, Leptin, Male rat.
Full-Text [PDF 517 kb]   (61 Downloads)    
Type of Study: Research | Subject: Sport Physiology
Received: 2019/05/11 | Accepted: 2019/09/15 | Published: 2020/01/12
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Qasemnia A, Zighami Z, Hadi S. The Effect of Eight Weeks of Increased Aerobic Exercise with Zinc Supplementation on Muscle Superoxide Dismutase Activity and Serum Leptin Levels and Weight Changes in Adult Wistar Rats. Armaghane danesh. 2019; 24 (6) :1054-1072
URL: http://armaghanj.yums.ac.ir/article-1-2526-en.html


Volume 24, Issue 6 (12-2019) Back to browse issues page
ارمغان دانش Armaghane danesh
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