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:: Volume 20, Number 7 (10-2015) ::
__Armaghane Danesh__ 2015, 20(7): 558-571 Back to browse issues page
Effect of Pre-nutrion of Flax Seed Oil (Linum Usitatissimum) on the amount of Cerebral ischemic lesion and motor nerve disorders in animal model rat.
SV Hosseini1, Mehdi Rahnema 2, Mohammad Reza Bigdeli3
1- Master Science 1Department of Animal physiology, Zanjan Branch, Islamic Azad university, Zanjan, Iran
2- Associate Professor 2Department of Animal physiology, Biology Research Center, Zanjan Branch, Islamic Azad University, Zanjan, Iran , meh_rahnema@yahoo.com
3- Associate Professor Department of Medical Physiology, Shahid Beheshti University, Tehran, Iran
Abstract:   (2240 Views)

Background & aim: Stroke is the third death agent (factor) in industrial countries after cardiovascular disease and cancer. With regard to high content of antioxidant materials in flax seed oil like &alpha-linolenic acid, lignan as well as phenolic combinations like secoisolarisirsinol (SDG), this study performed for studding relationship between of cerebral ischemic lesion and motor-nerve disorders in model of stroke in rat. Methods: in the study, 35 male mice from strain Wistar divided to 5 groups. The groups included control, sham and 3 experimental groups. They received doses 0.25, 0.5 and 0.75 ml/kg from flax seed oil orally. By gavage for 30 days two control and sham groups received aqua distillate (distil water). Two hours after the last gavaged dose, overly group with 7 pieces operated for measurement of the amount of cerebral lesion and motor-nerve disorders. (Middle Cerebral Artery Occlusion Model). Middle cerebral Artery Occlusion by the model resulted in local ischemic stroke in animal. Data analyzed by software SPSS, test ANOVA and disorders by test mann-Whitney. Findings: Average of records of motor-nerve disorders decreased significantly in group with dose 0.5 and 0.75 using flax seed oil (P<0.05). The amount of cerebral ischemic lesion in doses 0.5 and 0.75 than to control group is indicated meaning full different, but percent of the total cerebral lesion in control group in compared group with dose 0.25 is not indicated meaningful different. Percent of the amount of ischemic lesion in region penumbra in group 0.75 and 0.5 than to control group is indicated meaningful different, but percent of the amount of lesion in region penumbra in control group in compared region penumbra in group with dose 0.25 is not indicated meaning full different. Results: Findings of the study indicated that flax seed oil, particular in doses 0.5 and 0.75 resulted to decrease of the amount of cerebral ischemic lesion and decrease of motor-nerve disorders in animal model of stroke.

Keywords: Cerebral ischemia, Flaxseed oil, Rat, Motor nerve disorders.
Full-Text [PDF 417 kb]   (622 Downloads)    
Type of Study: Research | Subject: Physiology
Received: 2015/03/8 | Accepted: 2015/08/8 | Published: 2015/09/2
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Hosseini S, Rahnema M, Bigdeli M R. Effect of Pre-nutrion of Flax Seed Oil (Linum Usitatissimum) on the amount of Cerebral ischemic lesion and motor nerve disorders in animal model rat.. Armaghane danesh. 2015; 20 (7) :558-571
URL: http://armaghanj.yums.ac.ir/article-1-104-en.html
Volume 20, Number 7 (10-2015) Back to browse issues page
ارمغان دانش Armaghane danesh
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