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Anti-inflammatory Effect of Sodium Valproate on Carrageenan-Induced Paw Edema in Male Rat
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Mj Khoshnood   1, M Mokhtari , R Sehhat |
| 1- , khoshnoudm@sums.ac.ir |
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Abstract: (5706 Views) |
| ABESTRACT:
Introduction & objective: Inflammation is a body defensive response to the endogenous and exogenous stimulators such as chemical, radiation, trauma and invasive microorganism, which result pain and tissue necrosis. There are many natural and synthetic drugs for treatment of inflammation and lot of them are under investigation. Sodium valporate is an antiepileptic drug used particularly in the treatment of primary generalized seizure notably absence, myocolonic seizure, acute manic phase of bipolar disorder and prophylaxis of migraine. The previous observations showed sodium valporate increases level of gamma amino butyric acid (GABA) in the central and peripheral nervous system. In acute inflammation, GABA showed a significant attenuation of paw edema and nociception. The aim of this study was evaluation of anti-inflammatory effect of sodium valporate.
Materials & Methods: In order to evaluated the anti-inflammatory and antiexudative of sodium valporate doses of 200,400 and 600 mg/kg were investigated on rat paw edema that induced by carrageenan. In addition, the plasma leakage in the inflamed tissue was evaluated by application of trypan blue as intravenous injection. Dexamethason was used as positive control.
Results: Results showed sodium valporate doses of 400 and 600 mg/kg decreased inflammatory and exudative effect as compared to control group.
Conclusion: Although the anti-inflammatory mechanisms of this drug were not evident but we can say sodium valporate in addition to already proved effects has anti-inflammatory effect. |
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| Keywords: KEYWORDS:Sodium Valproate, Inflammation, Carrageenan |
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Full-Text [PDF 173 kb]
(1237 Downloads)
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Type of Study: Research |
Subject:
Special
Received: 2015/05/9 | Accepted: 2015/05/9 | Published: 2015/05/9
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