[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
:: Volume 17, Number 2 (6-2012) ::
__Armaghane Danesh__ 2012, 17(2): 102-110 Back to browse issues page
The Effect of Helicobacter pylori Colonization on Parietal Cells Alteration in Rat Stomach
F Aeini, MJ Rezaie 1, Y Motaharinia, MA Rezaee
1- , rezaiemj@muk.ac.ir
Abstract:   (1801 Views)
Background & Aim: Parietal cells have an important role in the production of stomach acid and function. Helicobacter pylori colonization in the stomach may affect the function of these cells. The aim of this study was to evaluate the effect of Helicobacter pylori colonization of rat stomach parietal cells. Methods: In this study, 10 rats in two experimental and control groups were divided. Animals were fed by Helicobacter pylori or PBS in the experimental and control groups respectively for 20 weeks. Afterwards, bacterial colonization and parietal cells alterations were evaluated in the stomach tissue, using different staining methods. Furthermore, apoptosis in these cells were evaluated by TUNEL method. Results: Helicobacter pylori colonization in rat stomach was confirmed. In addition, degradation and ultra-structural changes of parietal cells in the experimental group was determined after 20 weeks. TUNEL staining results were indicative of parietal cells apoptosis in the experimental group. Conclusion: This study confirmed that Helicobacter pylori in 20 weeks duration causes degradation and structural changes in rat stomach parietal cells and cell death could be through apoptosis.
Keywords: Helicobacter pylori, Parietal cell, Rat
Full-Text [DOC 426 kb]   (761 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/04/26 | Accepted: 2015/04/26 | Published: 2015/04/26
Send email to the article author

Add your comments about this article
Your username or email:

Write the security code in the box >



XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Aeini F, Rezaie M, Motaharinia Y, Rezaee M. The Effect of Helicobacter pylori Colonization on Parietal Cells Alteration in Rat Stomach. Armaghane danesh. 2012; 17 (2) :102-110
URL: http://armaghanj.yums.ac.ir/article-1-297-en.html
Volume 17, Number 2 (6-2012) Back to browse issues page
ارمغان دانش Armaghane danesh
Persian site map - English site map - Created in 0.047 seconds with 792 queries by yektaweb 3461