[Home ] [Archive]   [ فارسی ]  
:: Main :: About :: Current Issue :: Archive :: Search :: Submit :: Contact ::
Main Menu
Home::
Journal Information::
Articles archive::
For Authors::
For Reviewers::
Registration::
Contact us::
Site Facilities::
Indexing & Abstracting::
Publication Ethics::
::
Search in website

Advanced Search
..
Receive site information
Enter your Email in the following box to receive the site news and information.
..
Indexing & Abstracting
DOAJ
GOOGLE SCHOLAR
..
:: Volume 16, Issue 6 (2-2012) ::
__Armaghane Danesh__ 2012, 16(6): 507-516 Back to browse issues page
Histidine Neuroprotective Effect on CA1 Region of Rat Hippocampus Following Transient Brain Ischemia
H Vaghefi Eftekhar , V Sheibani , A Mohammadi pour 1, A Aboli
1- , mohammadia881@mums.ac.ir
Abstract:   (4235 Views)
Background & Aim: There are multiple processes that lead to cell death after brain ischemia, such as glutamate release and inflammatory reactions. Histamine is able to suppress inflammatory reactions and glutamate release. Since histidine is precursor of histamine, this study was conducted to evaluate its neuroprotective effects on CA1 region of rat hippocampus following brain ischemia. Methods: In the present experimental study, thirty-six male Wistar rats were randomly divided into six groups as the following: control, surgical control, ischemia, and three groups which different doses (200, 500, and 1000 mg/kg) of histidine. Focal cerebral ischemia, for 60 min, was provoked by transient occlusion of the right middle cerebral artery in all groups except the two control groups, and histidine neuro-protective effects on neuronal death was evaluated in CA1 of hippocampus neurons after 7 days. The gathered data was analyzed using one-way ANOVA. Results: The results showed that the mean number of neuronal degeneration and pancellular necrosis in groups which received doses of 500 and 1000 mg/kg of histidine have significantly decreased in comparison with the ischemia group (p=0.001). This reduction in dose of 200 mg/kg of histidine was not statistically significant (p=0.05). Conclusion: Our present findings show that intraperitoneal administration of histidine before reperfusion alleviated CA1 damage.
Keywords: Brain Ischemia, CA1, Histidine
Full-Text [PDF 481 kb]   (1330 Downloads)    
Type of Study: Research | Subject: Special
Received: 2015/04/25 | Accepted: 2015/04/25 | Published: 2015/04/25
Send email to the article author

Add your comments about this article
Your username or Email:

CAPTCHA


XML   Persian Abstract   Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Vaghefi Eftekhar H, Sheibani V, Mohammadi pour A, Aboli A. Histidine Neuroprotective Effect on CA1 Region of Rat Hippocampus Following Transient Brain Ischemia. armaghanj 2012; 16 (6) :507-516
URL: http://armaghanj.yums.ac.ir/article-1-286-en.html


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Volume 16, Issue 6 (2-2012) Back to browse issues page
ارمغان دانش Armaghane Danesh
Persian site map - English site map - Created in 0.05 seconds with 38 queries by YEKTAWEB 4645